The Potential of Freeform Construction Processes

The level of automation technology and processes control found in modern day construction lags significantly behind other industries such as automotive and aerospace. The construction industry has health and safety issues and still uses traditional methods of procurement. These problems are compounded by diminishing skills in the labour force. Methods of production must change if these issues are to be resolved and Freeform Construction is a collection of processes that could have potential impact. This paper outlines some of the major issues facing construction and sets a context with examples of digital fabrication in construction. Freeform Construction is defined and potential applications are presented and related to application scale. The viability of two potential applications are investigated in terms of cost.Mechanical Engineerin

A development appraisal from the management viewpoint of the use of cost-benefit analysis in in-company training situations

The thesis takes the economist's concept of cost-benefit analysis and subjects it to a ‘developmental appraisal', from the management viewpoint and in respect of ‘in-company training'. In so doing it seeks to explore the contribution that the broad concept, when applied to training evaluation, can make to management decision making. The thesis concludes from an appraisal of the cost-benefit concept that differences when it is applied to in-company training compared with the economists traditional 'macro' usage, merit a different label, 'investment appraisal' of training. The place of the concept in training evaluation is then explored and in use it is shown to be subject to a great many constraints. The thesis proposes that these constraints be translated as opportunities within a 'new' framework which seeks to consider training evaluation from the management viewpoint. This framework proposes a twin role for evaluation: the conventional one of feedback to the trainer and organisation; and an additional one of identification of the key 'supportive' systems needed to meet the objectives of a particular programme. To test these roles a dichotomy is proposed between Programmed and non-Programmed training decisions, within which a classification of types of training is suggested. The investment appraisal concept is then applied to evaluations within each of these decision categories. The non-Programmed decision evaluation is conducted in an operative training situation in a rolling mill in the steel industry; the Programmed Decision evaluation is applied to a junior operative training programme in several steel companies. The thesis concludes from the results of the experiments that a useful methodology has been devised and that the major contribution of the application of the concept in practice is the opportunity it gives both for the identification of line management contribution to the success of training and obtaining of their involvement

Survival of HIV-1 vertically infected children

PURPOSE OF REVIEW: It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. RECENT FINDINGS: Good survival has been achieved on cART in all settings with up to 10-fold mortality reductions compared with before cART availability. Although mortality risk remains high in the first few months after cART initiation in young children with severe disease, it drops rapidly thereafter even for those who started with advanced disease, and longer term mortality risk is low. However, suboptimal retention on cART in routine programs threatens good survival outcomes and even on treatment children continue to experience high comorbidity risk; infections remain the major cause of death. Interventions to address infection risk include a cotrimoxazole prophylaxis, isoniazid preventive therapy, routine childhood and influenza immunization, and improving maternal survival. SUMMARY: Pediatric survival has improved substantially with cART and HIV-infected children are aging into adulthood. It is important to ensure access to diagnosis and early cART, good program retention as well as optimal comorbidity prophylaxis and treatment to achieve the best possible long-term survival and health outcomes for vertically infected children

Warm HCN, C2H2, and CO in the disk of GV Tau

We present the first high-resolution, ground-based observations of HCN and C2H2 toward the T Tauri binary star system GV Tau. We detected strong absorption due to HCN nu_3 and weak C2H2 (nu_3 and nu_2 + (nu_4 + nu_5)^0_+) absorption toward the primary (GV Tau S) but not the infrared companion. We also report CO column densities and rotational temperatures, and present abundances relative to CO of HCN/CO ~0.6% and C2H2/CO ~1.2% and an upper limit for CH4/CO < 0.37% toward GV Tau S. Neither HCN nor C2H2 were detected toward the infrared companion and results suggest that abundances may differ between the two sources.Comment: 23 pages, 6 figures, accepted by Ap

Dawn to dusk counts of common or garden birds, Wellington, New Zealand

Abstract Common Iand-birds in a rural suburban garden, Wellington, New Zealand, were counted for 10 minutes twice an hour, twice a month for 2 years, from dawn to dusk. The birds&apos; behaviour sometimes changed or they entered or left the study area during the day; so there is no ided time of day for counting buds

Nuclear BK channels regulate CREB phosphorylation in RAW264.7 macrophages

BACKGROUND: Macrophages are important cells of the innate immune system and contribute to a variety of physiological and pathophysiological responses. Monovalent and divalent ion channels have been studied in macrophage function, and while much research is still required, a role for these channels is beginning to emerge in macrophages. In addition to the plasma membrane, ion channels are also found in intracellular membranes including mitochondrial, lysosomal and nuclear membranes. While studying the function of plasma membrane located large conductance voltage- and calcium-activated potassium channels (BK channels) in a macrophage cell line RAW264.7, we became aware of the expression of these ion channels in other cellular locations. METHODS: Immunofluorescence and Western blot analysis were used to identify the expression of BK channels. To demonstrate a functional role for the nuclear located channel, we investigated the effect of the lipid soluble BK channel inhibitor paxilline on CREB phosphorylation. RESULTS: Treatment of resting macrophages with paxilline resulted in increased CREB phosphorylation. To confirm a role for nuclear BK channels, these experiments were repeated in isolated nuclei and similar results were found. Ca2+ and calmodulin-dependent kinases (CaMK) have been demonstrated to regulate CREB phosphorylation. Inhibition of CaMKII and CaMKIV resulted in the reversal of paxilline-induced CREB phosphorylation. CONCLUSIONS: These results suggest that nuclear BK channels regulate CREB phosphorylation in macrophages. Nuclear located ion channels may therefore be part of novel signalling pathways in macrophages and should be taken into account when studying the role of ion channels in these and other cells

Uniaxial magnetocrystalline anisotropy in CaRuO3{\rm CaRuO_3}

${\rm CaRuO_3}$ is a paramagnetic metal and since its low temperature resistivity is described by $\rho=\rho_0+AT^\gamma$ with $\gamma \sim 1.5$, it is also considered a non-Fermi liquid (NFL) metal. We have performed extensive magnetoresistance and Hall effect measurements of untwinned epitaxial films of ${\rm CaRuO_3}$. These measurements reveal that ${\rm CaRuO_3}$ exhibits uniaxial magnetocrystalline anisotropy. In addition, the low-temperature NFL behavior is most effectively suppressed when a magnetic field is applied along the easy axis, suggesting that critical spin fluctuations, possibly due to proximity of a quantum critical phase transition, are related to the NFL behavior.Comment: 7 figure

Geophysical characteristics and crustal structure of greenstone terranes: Canadian Shield

Geophysical studies in the Canadian Shield have provided some insights into the tectonic setting of greenstone belts. Greenstone belts are not rooted in deep crustal structures. Geophysical techniques consistently indicate that greenstones are restricted to the uppermost 10 km or so of crust and are underlain by geophysically normal crust. Gravity models suggest that granitic elements are similarly restricted, although magnetic modelling suggests possible downward extension to the intermediate discontinuity around approx. 18 km. Seismic evidence demonstrates that steeply-dipping structure, which can be associated with the belts in the upper crust, is not present in the lower crust. Horizontal intermediate discontinuities mapped under adjacent greenstone and granitic components are not noticeably disrupted in the boundary zone. Geophysical evidence points to the presence of discontinuities between greenhouse-granite and adjacent metasedimentary erranes. Measured stratigraphic thicknesses of greenstone belts are often twice or more the vertical thicknesses determined from gravity modelling. Explantations advanced for the discrepancy include stratigraphy repeated by thrust faulting and/or listric normal faulting, mechanisms which are consistent with certain aspects of conceptual models of greenstone development. Where repetition is not a factor the gravity evidence points to removal of the root zones of greenstone belts. For one region, this has been attributed to magmatic stopping during resurgent caldera activity