Combat Veterans, Mental Health Issues, and the Death Penalty: Addressing the Impact of Post-Traumatic Stress Disorder and Traumatic Brain Injury

More than 1.5 million Americans have participated in combat operations in Iraq and Afghanistan over the past seven years. Some of these veterans have subsequently committed capital crimes and found themselves in our nation’s criminal justice system. This Essay argues that combat veterans suffering from post-traumatic stress disorder or traumatic brain injury at the time of their offenses should not be subject to the death penalty. Offering mitigating evidence regarding military training, post-traumatic stress disorder, and traumatic brain injury presents one means that combat veterans may use to argue for their lives during the sentencing phase of their trials. Alternatively, Atkins v. Virginia and Roper v. Simmons offer a framework for establishing a legislatively or judicially created categorical exclusion for these offenders, exempting them from the death penalty as a matter of law. By understanding how combat service and service-related injuries affect the personal culpability of these offenders, the legal system can avoid the consequences of sentencing to death America’s mentally wounded warriors, ensuring that only the worst offenders are subject to the ultimate punishment

How Do Software Startups Pivot? Empirical Results from a Multiple Case Study

In order to handle intense time pressure and survive in dynamic market, software startups have to make crucial decisions constantly on whether to change directions or stay on chosen courses, or in the terms of Lean Startup, to pivot or to persevere. The existing research and knowledge on software startup pivots are very limited. In this study, we focused on understanding the pivoting processes of software startups, and identified the triggering factors and pivot types. To achieve this, we employed a multiple case study approach, and analyzed the data obtained from four software startups. The initial findings show that different software startups make different types of pivots related to business and technology during their product development life cycle. The pivots are triggered by various factors including negative customer feedback.Comment: Conference publication, International Conference on Software Business (ICSOB'16), Sloveni

IL RECETTORE DELLA DOPAMINA DI TIPO 2 (DRD2) INIBISCE LA MIGRAZIONE DI CELLULE DI ADENOMA IPOFISARIO NON SECERNENTE TRAMITE INATTIVAZIONE DI COFILINA

Non-functioning pituitary adenomas (NFPAs) are benign in nature, frequently present local invasiveness that strongly reduces neurosurgery success. Medical therapy is still under debate, although evidences indicate that dopamine (DA) receptor 2 (DRD2) agonists induce tumor shrinkage in some patients. Aims of this study were: to evaluate the effect of DR2D agonist BIM53097 on migration and invasion of NFPA cells, and to investigate the molecular mechanisms regulating the motility of these cells, focusing on the role of cofilin, an actin severing protein involved in actin reorganization. Our data demonstrated that BIM53097 incubation significantly reduced cell migration (42\ub16% p<0.05) and invasion (32\ub12%, p<0.01) and increased about 4-fold cofilin phosphorylation at Ser3 in a subset of NFPAs, these data being replicated in HP75 cells. Both these effects were completely abolished by ROCK inhibitor Y-27632. The overexpression of wild type or phospho-deficient (S3A) cofilin in HP75 cells increased cell migration (49\ub16% and 57\ub19% increase vs empty vector, respectively, p<0.05), suggesting a causal role for active (dephosphorylated) cofilin in cell motility. In agreement, invasive NFPAs showed lower phospho-cofilin/total cofilin ratio with respect to non invasive tumors. In conclusion, our data reveal that DRD2 agonist reduced NFPA cells migration through a molecular mechanism that involves ROCK-dependent phosphorylation of cofilin, and suggest that cofilin phosphorylation status might be a molecular marker associated with the invasive behaviour of NFPAs

Complement system network in cell physiology and in human diseases

The complement system is a multi-functional system representing the first line host defense against pathogens in innate immune response, through three different pathways. Impairment of its function, consisting in deficiency or excessive deregulated activation, may lead to severe systemic infections or autoimmune disorders. These diseases may be inherited or acquired. Despite many diagnostic tools are currently available, ranging from traditional, such as hemolytic or ELISA based assays, to innovative ones, like next generation sequencing techniques, these diseases are often not recognized. As for therapeutic aspects, strategies based on the use of targeted drugs are now widespread. The aim of this review is to present an updated overview of complement system pathophysiology, clinical implications of its dysfunction and to summarize diagnostic and therapeutic approaches

Underserved Populations in the United States: Research, Response and Resilience

Angelo P. Giardino, Robert Sanborn, William V. Flores and E. Christopher Lloyd discuss the latest issue of the Journal of Family Strengths

Constraints on the Universal Varying Yukawa Couplings: from SM-like to Fermiophobic

Varying the Standard Model (SM) fermion Yukawa couplings universally by a generic positive scale factor ($F_{Yu}$), we study the phenomenological fit to the current available experimental results for the Higgs boson search at hadron colliders. We point out that the Higgs production cross section and its decay branching ratio to $\gamma\gamma$ can be varied oppositely by $F_{Yu}$ to make their product almost invariant. Thus, our scenario and the SM Higgs are indistinguishable in the inclusive $H\to \gamma\gamma$ channel. The current measurements on direct Yukawa coupling strength in the $H\to b\bar{b}/\tau\tau$ channel are not precise enough to fix the scale factor $F_{Yu}$. The most promising is the vector-boson-fusion channel in which the CMS has already observed possible suppression effect on the Yukawa couplings. Further more, the global $\chi^2$ fit of the experimental data can get the optimal value by introducing a suppression factor $F_{Yu}\sim1/2$ on the SM Yukawa couplings.Comment: 16 pages, 12 figures, 5 tables, update analysis is supplemente

Spectrophotometric properties of dwarf planet Ceres from the VIR spectrometer on board the Dawn mission

We study the spectrophotometric properties of dwarf planet Ceres in the VIS-IR spectral range by means of hyper-spectral images acquired by the VIR imaging spectrometer on board the NASA Dawn mission. Disk-resolved observations with a phase angle within the $7^{\circ}<\alpha<132^{\circ}$ interval were used to characterize Ceres' phase curve in the 0.465-4.05 $\mu$m spectral range. Hapke's model was applied to perform the photometric correction of the dataset, allowing us to produce albedo and color maps of the surface. The $V$-band magnitude phase function of Ceres was fitted with both the classical linear model and H-G formalism. The single-scattering albedo and the asymmetry parameter at 0.55$\mu$m are $w=0.14\pm0.02$ and $\xi=-0.11\pm0.08$, respectively (two-lobe Henyey-Greenstein phase function); the modeled geometric albedo is $0.094\pm0.007$; the roughness parameter is $\bar{\theta}=29^{\circ}\pm6^{\circ}$. Albedo maps indicate small variability on a global scale with an average reflectance of $0.034 \pm 0.003$. Isolated areas such as the Occator bright spots, Haulani, and Oxo show an albedo much higher than average. We measure a significant spectral phase reddening, and the average spectral slope of Ceres' surface after photometric correction is $1.1\%k\AA^{-1}$ and $0.85\%k\AA^{-1}$ at VIS and IR wavelengths, respectively. Broadband color indices are $V-R=0.38\pm0.01$ and $R-I=0.33\pm0.02$. H-G modeling of the $V$-band magnitude phase curve for $\alpha<30^{\circ}$ gives $H=3.14\pm0.04$ and $G=0.10\pm0.04$, while the classical linear model provides $V(1,1,0^{\circ})=3.48\pm0.03$ and $\beta=0.036\pm0.002$. The comparison with spectrophotometric properties of other minor bodies indicates that Ceres has a less back-scattering phase function and a slightly higher albedo than comets and C-type objects. However, the latter represents the closest match in the usual asteroid taxonomy.Comment: 14 pages, 20 figures, published online on Astronomy and Astrophysics on 13 February 2017. Revised to reflect minor changes in text and figures made in proofs, updated value of V-R and R-