3 research outputs found
Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144â509 valid brachial and 130â804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mmâHg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mmâHg and 115, 117, and 107 mmâHg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mmâHg and for 24-hour cSBPSBP/DBPcal 120 mmâHg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation
Twenty-fourhour central (aortic) systolic blood pressure : reference values and dipping patterns in untreated individuals
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18â94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBP(MAP/DBPcal)), or bSBP/diastolic blood pressure (cSBP(SBP/DBPcal)), and a validated transfer function, resulting in 144â509 valid brachial and 130â804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mmâHg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBP(MAP/DBPcal) were 128, 128, and 125 mmâHg and 115, 117, and 107 mmâHg for cSBP(SBP/DBPcal), respectively. We pragmatically propose as upper normal limit for 24-hour cSBP(MAP/DBPcal) 135 mmâHg and for 24-hour cSBP(SBP/DBPcal) 120 mmâHg. bSBP dipping (nighttime-daytime/daytime SBP) was â10.6 % in young participants and decreased with increasing age. Central SBP(SBP/DBPcal) dipping was less pronounced (â8.7% in young participants). In contrast, cSBP(MAP/DBPcal) dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation
Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by
the heart, the brain, and the kidneys. If properly measured, cSBP is
closer associated with hypertension-mediated organ damage and prognosis,
as compared with brachial SBP (bSBP). We investigated 24-hour profiles
of bSBP and cSBP, measured simultaneously using Mobilograph devices, in
2423 untreated adults (1275 women; age, 18-94 years), free from overt
cardiovascular disease, aiming to develop reference values and to
analyze daytime-nighttime variability. Central SBP was assessed, using
brachial waveforms, calibrated with mean arterial pressure
(MAP)/diastolic BP (cSBP(MAP/DBPcal)), or bSBP/diastolic blood pressure
(cSBP(SBP/DBPcal)), and a validated transfer function, resulting in 144
509 valid brachial and 130 804 valid central measurements. Averaged
24-hour, daytime, and nighttime brachial BP across all individuals was
124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour,
daytime, and nighttime values for cSBP(MAP/DBPcal) were 128, 128, and
125 mm Hg and 115, 117, and 107 mm Hg for cSBP(SBP/DBPcal),
respectively. We pragmatically propose as upper normal limit for 24-hour
cSBP(MAP/DBPcal) 135 mm Hg and for 24-hour cSBP(SBP/DBPcal) 120 mm Hg.
bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young
participants and decreased with increasing age. Central SBPSBP/DBPcal
dipping was less pronounced (-8.7% in young participants). In contrast,
cSBP(MAP/DBPcal) dipping was completely absent in the youngest age group
and less pronounced in all other participants. These data may serve for
comparison in various diseases and have potential implications for
refining hypertension diagnosis and management. The different dipping
behavior of bSBP versus cSBP requires further investigation