Medical implantable devices for the controlled release of anti-TGF-beta1 in the repair of peripheral nerve injuries

The development of novel bioartificial nerve grafts which release soluble therapeutic agents, shows great promises guiding the extension of the injured axons and optimizing and improving the degree and specificity of neural outgrowth. The TGF-â family cytokines are polypeptides involved in pathogenesis of neuropathies during nerve lesion. In particular, studies carried out on TGF-â1 have demonstrated its key-role as a humoral stimulus in scar formation. The use of neutralising antibodies to this pro-fibrotic factor, incorporated and released by medical devices, could be potentially useful to get improved results in nerve repair. The aim of this study was to characterise the uptake and release of antibodies, structurally no different from the anti-TGFâ1 specific ones, by innovative constructs based on the use of biodegradable and biocompatible compounds with which to support and improve peripheral nerve repair

Some exact solutions with torsion in 5-D Einstein-Gauss-Bonnet gravity

Exact solutions with torsion in Einstein-Gauss-Bonnet gravity are derived. These solutions have a cross product structure of two constant curvature manifolds. The equations of motion give a relation for the coupling constants of the theory in order to have solutions with nontrivial torsion. This relation is not the Chern-Simons combination. One of the solutions has a $AdS_2\times S^3$ structure and is so the purely gravitational analogue of the Bertotti-Robinson space-time where the torsion can be seen as the dual of the covariantly constant electromagnetic field.Comment: 19 pages, LaTex, no figures. References added, notation clarified. Accepted for publication on Physical Review

Black holes with gravitational hair in higher dimensions

A new class of vacuum black holes for the most general gravity theory leading to second order field equations in the metric in even dimensions is presented. These space-times are locally AdS in the asymptotic region, and are characterized by a continuous parameter that does not enter in the conserve charges, nor it can be reabsorbed by a coordinate transformation: it is therefore a purely gravitational hair. The black holes are constructed as a warped product of a two-dimensional space-time, which resembles the r-t plane of the BTZ black hole, times a warp factor multiplying the metric of a D-2-dimensional Euclidean base manifold, which is restricted by a scalar equation. It is shown that all the Noether charges vanish. Furthermore, this is consistent with the Euclidean action approach: even though the black hole has a finite temperature, both the entropy and the mass vanish. Interesting examples of base manifolds are given in eight dimensions which are products of Thurston geometries, giving then a nontrivial topology to the black hole horizon. The possibility of introducing a torsional hair for these solutions is also discussed

On the number of limit cycles of the Lienard equation

In this paper, we study a Lienard system of the form dot{x}=y-F(x), dot{y}=-x, where F(x) is an odd polynomial. We introduce a method that gives a sequence of algebraic approximations to the equation of each limit cycle of the system. This sequence seems to converge to the exact equation of each limit cycle. We obtain also a sequence of polynomials R_n(x) whose roots of odd multiplicity are related to the number and location of the limit cycles of the system.Comment: 10 pages, 5 figures. Submitted to Physical Review

Localizing limit cycles : from numeric to analytical results

Presentation given by participants of the joint international multidisciplinary workshop MURPHYS-HSFS-2016 (MUltiRate Processes and HYSteresis; Hysteresis and Slow-Fast Systems), which was dedicated to the mathematical theory and applications of multiple scale systems and systems with hysteresis, and held at the Centre de Recerca Matemàtica (CRM) in Barcelona from June 13th to 17th, 2016This note presents the results of [4]. It deals with the problem of location and existence of limit cycles for real planar polynomial differential systems. We provide a method to construct Poincaré-Bendixson regions by using transversal curves, that enables us to prove the existence of a limit cycle that has been numerically detected. We apply our results to several known systems, like the Brusselator one or some Liénard systems, to prove the existence of the limit cycles and to locate them very precisely in the phase space. Our method, combined with some other classical tools can be applied to obtain sharp bounds for the bifurcation values of a saddle-node bifurcation of limit cycles, as we do for the Rychkov syste

Is executive function associatedwith symptom severity in schizophrenia?

Abstract.: This paper reports on a study that was designed to investigate the relationship between psychopathology and executive functions in schizophrenia. Correlations were sparse and mostly weak. The most robust finding was the association between letter fluency and negative symptoms; however, most other applied tasks were not associated with symptom level. Our results support previous findings of differential relationships between impaired executive functions and symptom leve