Cervical lymph node metastasis in squamous cell carcinoma of the buccal mucosa:a retrospective study on pattern of involvement and clinical analysis

The study was performed with an aim to map the pattern of metastasis of squamous cell carcinomas of buccal mucosa to various cervical lymph node levels and analyze its correlation with primary tumor size and histo-pathological grading. 254 patients with squamous cell carcinoma of the buccal mucosa treated with surgery first approach were analyzed retrospectively. The tumor size was noted from pre-operative CT Scans and were divided into early and advanced tumors. The resected specimen was studied to note the histo-pathological grading of the squamous cell carcinoma and the metastatic deposits at various lymph node levels. Out of 254 patients (149 females, 105 males), 145 patients showed histo-pathologically proven metastatic deposits in one or more lymph nodes out of which there were 56 patients showing occult metastasis. 78/145 patients showed metastatic involvement of level IB and/or IA lymph nodes, 31 showed involvement of level II and/or I lymph nodes, 27 showed involvement of level III with or without involvement of level I and II and 9 showed metastasis to level IV and V lymph nodes with or without level I, II or III lymph nodes. Cervical lymph node metastasis had statistically significant association with tumor size with advanced tumors showing worse pattern of metastatic spread beyond level I and II lymph nodes. As the degree of differentiation of squamous cell carcinoma reduced, they were more prone for cervical metastasis with moderately and poorly differentiated squamous cell carcinoma showing higher involvement of level III, IV and V lymph nodes. The majority of buccal mucosa cases showed metastasis to level I, II and III lymph nodes out of which level IB and/or IA was most frequently involved. Metastasis to level IV and V lymph nodes was rare and was seen especially in patients with advanced primary tumor and poor histo-pathologic differentiation

Synthesis of the tricyclic core of manzamine A

An efficient synthetic approach to the core structure of the manzamine alkaloids is reported, particularly in relation to incorporating a one-carbon unit in ring B from which the aldehyde in ircinal A or the beta-carboline unit in manzamine A could potentially be generated. The key steps involve a Johnson–Claisen rearrangement, enolate alkylation, dithiane alkylation and a stereoselective intramolecular dipolar cycloaddition of an azomethine ylide, which provided the desired tricyclic ABC core structure

R-parity-violating SUSY and CP violation in B --> phi K_s

Recent measurements of CP asymmetry in B --> phi K_S appear to be inconsistent with Standard Model expectations. We explore the effect of R-parity-violating SUSY to understand the data.Comment: Equations corrected. Conclusions unchanged. Latex, 6 pages, one fi

Higher dimensional radiation collapse and cosmic censorship

We study the occurrence of naked singularities in the spherically symmetric collapse of radiation shells in a higher dimensional spacetime. The necessary conditions for the formation of a naked singularity or a black hole are obtained. The naked singularities are found to be strong in the Tipler's sense and thus violating cosmic censorship conjecture.Comment: 4 pages, ReVTeX, Phys Rev D Vol 62 107502 (2000

Realistic Anomaly Mediation with Bulk Gauge Fields

We present a simple general framework for realistic models of supersymmetry breaking driven by anomaly mediation. We consider a 5-dimensional "brane universe" where the visible and hidden sectors are localized on different branes, and the standard model gauge bosons propagate in the bulk. In this framework there can be charged scalar messengers that have contact interactions with the hidden sector, either localized in the hidden sector or in the bulk. These scalars obtain soft masses that feed into visible sector scalar masses at two loop order via bulk gauge interactions. This contribution is automatically flavor-blind, and can be naturally positive. If the messengers are in the bulk this contribution is automatically the same order of magnitude as the anomaly mediated contribution, independent of the brane spacing. If the messengers are localized to a brane the two effects are of the same order for relatively small brane spacings. The gaugino masses and A terms are determined completely by anomaly mediation. In order for anomaly mediation to dominate over radion mediation the radion must be is stabilized in a manner that preserves supersymmetry, with supergravity effects included. We show that this occurs in simple models. We also show that the mu problem can be solved by the vacuum expectation value of a singlet in this framework.Comment: 16 pages, LaTeX2e, no figure

Gravitational Collapse of Null Radiation and a String fluid

We consider the end state of collapsing null radiation with a string fluid. It is shown that, if diffusive transport is assumed for the string, that a naked singularity can form (at least locally). The model has the advantage of not being asymptotically flat. We also analyse the case of a radiation-string two-fluid and show that a locally naked singularity can result in the collapse of such matter. We contrast this model with that of strange quark matter.Comment: RevTeX 4.0 (8 pages - no figures). submitted to Phys Rev D. Some changes to abstract, introduction and conclusion - references update

Nature of singularity formed by the gravitational collapse in Husain space-time with electromagnetic field and scalar field

In this work, we have investigated the outcome of gravitational collapse in Husain space-time in the presence of electro-magnetic and a scalar field with potential. In order to study the nature of the singularity, global behavior of radial null geodesics have been taken into account. The nature of singularities formed has been thoroughly studied for all possible variations of the parameters. These choices of parameters has been presented in tabular form in various dimensions. It is seen that irrespective of whatever values of the parameters chosen, the collapse always results in a naked singularity in all dimensions. There is less possibility of formation of a black hole. Hence this work is a significant counterexample of the cosmic censorship hypothesis.Comment: 9 pages, 19 figure

New-Physics Effects on Triple-Product Correlations in Lambda_b Decays

We adopt an effective-lagrangian approach to compute the new-physics contributions to T-violating triple-product correlations in charmless Lambda_b decays. We use factorization and work to leading order in the heavy-quark expansion. We find that the standard-model (SM) predictions for such correlations can be significantly modified. For example, triple products which are expected to vanish in the SM can be enormous (~50%) in the presence of new physics. By measuring triple products in a variety of Lambda_b decays, one can diagnose which new-physics operators are or are not present. Our general results can be applied to any specific model of new physics by simply calculating which operators appear in that model.Comment: 20 pages, LaTeX, no figures. Added a paragraph (+ references) discussing nonfactorizable effects. Conclusions unchange

Histone deacetylase 11 inhibition promotes breast cancer metastasis from lymph nodes

Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet the occurrence of cancer spreading from LNs remains controversial. Additionally, the mechanisms explaining how cancers survive and exit LNs are largely unknown. Here, we show that breast cancer patients frequently have LN metastases that closely resemble distant metastases. In addition, using a microsurgical model, we show how LN metastasis development and dissemination is regulated by the expression of a chromatin modifier, histone deacetylase 11 (HDAC11). Genetic and pharmacologic blockade of HDAC11 decreases LN tumor growth, yet substantially increases migration and distant metastasis formation. Collectively, we reveal a mechanism explaining how HDAC11 plasticity promotes breast cancer growth as well as dissemination from LNs and suggest caution with the use of HDAC inhibitors

Why do naked singularities form in gravitational collapse?

We investigate what are the key physical features that cause the development of a naked singularity, rather than a black hole, as the end-state of spherical gravitational collapse. We show that sufficiently strong shearing effects near the singularity delay the formation of the apparent horizon. This exposes the singularity to an external observer, in contrast to a black hole, which is hidden behind an event horizon due to the early formation of an apparent horizon.Comment: revised for clarity, new figure included; version accepted by Phys. Rev. D (RC