Learning Cross-Modal Deep Embeddings for Multi-Object Image Retrieval using Text and Sketch

In this work we introduce a cross modal image retrieval system that allows both text and sketch as input modalities for the query. A cross-modal deep network architecture is formulated to jointly model the sketch and text input modalities as well as the the image output modality, learning a common embedding between text and images and between sketches and images. In addition, an attention model is used to selectively focus the attention on the different objects of the image, allowing for retrieval with multiple objects in the query. Experiments show that the proposed method performs the best in both single and multiple object image retrieval in standard datasets.Comment: Accepted at ICPR 201

Performance Measures in Acousto-optic Chaotic Signal Encryption System Subject to Parametric Variations and Additive Noise

Signal encryption and recovery using chaotic optical waves has been a subject of active research in the past 10 years. Since an acousto-optic Bragg cell with zeroth- and first-order feedback exhibits chaotic behavior past the threshold for bistability, such a system was recently examined for possible chaotic encryption using a low-amplitude sinusoidal signal applied via the bias input of the sound cell driver. Subsequent recovery of the message signal was carried out via a heterodyne strategy employing a locally generated chaotic carrier, with threshold parameters matched to the transmitting Bragg cell. The simulation results, though encouraging, were limited to relatively low chaos frequencies and sinusoidal message signals only. In this paper, we extend the previous work by (i) increasing the chaos frequency using appropriate parameter control; (ii) carefully examining the system sensitivity to three system parameters, viz., feedback delay, feedback gain, and dc bias level; (iii) examine signal recoverability relative to shifts in the three parameters mentioned above relative to the transmitter; and (iv) determining the robustness of such a system relative to the primary transmitter parameters. Additionally, we consider the effect of the additive bandpass noise (obtained from white Gaussian noise in the simulator) on signal recovery in such a system from a performance standpoint. It is also conjectured that signal recovery can be effected by passing the modulated light through a second sound cell in a matched chaotic regime. This aspect is also under investigation

Design of Acousto-optic Chaos Based Secure Free-space Optical Communication Links

We discuss the design of an acousto-optic cell based free space optical communication link where the data beam is made secure through chaos encryption. Using external signal modulation of the diffracted light from a hybrid acousto-optic cell chaos (or directly via incorporation in the sound-cell driver\u27s bias voltage) encryption of data is possible. We have shown numerically that decryption of the encoded data is possible by using an identical acousto-optic system in the receiver

Chronic hepatitis B virus case-finding in UK populations born abroad in intermediate or high endemicity countries: an economic evaluation.

OBJECTIVES: The majority (>90%) of new or undiagnosed cases of hepatitis B virus (HBV) in the UK are among individuals born in countries with intermediate or high prevalence levels (≥2%). We evaluate the cost-effectiveness of increased HBV case-finding among UK migrant populations, based on a one-time opt out case-finding approach in a primary care setting. DESIGN: Cost-effectiveness evaluation. A decision model based on a Markov approach was built to assess the progression of HBV infection with and without treatment as a result of case-finding. The model parameters, including the cost and effects of case-finding and treatment, were estimated from the literature. All costs were expressed in 2017/2018 British Pounds (GBPs) and health outcomes as quality-adjusted life-years (QALYs). INTERVENTION: Hepatitis B virus case-finding among UK migrant populations born in countries with intermediate or high prevalence levels (≥2%) in a primary care setting compared with no intervention (background testing). RESULTS: At a 2% hepatitis B surface antigen (HBsAg) prevalence, the case-finding intervention led to a mean incremental cost-effectiveness ratio of £13 625 per QALY gained which was 87% and 98% likely of being cost-effective at willingness to pay (WTP) thresholds of £20 000 and £30 000 per additional QALY, respectively. Sensitivity analyses indicated that the intervention would remain cost-effective under a £20 000 WTP threshold as long as HBsAg prevalence among the migrant population is at least 1%. However, the results were sensitive to a number of parameters, especially the time horizon and probability of treatment uptake. CONCLUSIONS: HBV case-finding using a one-time opt out approach in primary care settings is very likely to be cost-effective among UK migrant populations with HBsAg prevalence ≥1% if the WTP for an additional QALY is around £20 000

In Vitro Structural and Functional Evaluation of Gold Nanoparticles Conjugated Antibiotics

Bactericidal efficacy of gold nanoparticles conjugated with ampicillin, streptomycin and kanamycin were evaluated. Gold nanoparticles (Gnps) were conjugated with the antibiotics during the synthesis of nanoparticles utilizing the combined reducing property of antibiotics and sodium borohydride. The conjugation of nanoparticles was confirmed by dynamic light scattering (DLS) and electron microscopic (EM) studies. Such Gnps conjugated antibiotics showed greater bactericidal activity in standard agar well diffusion assay. The minimal inhibitory concentration (MIC) values of all the three antibiotics along with their Gnps conjugated forms were determined in three bacterial strains,Escherichia coli DH5α,Micrococcus luteusandStaphylococcus aureus. Among them, streptomycin and kanamycin showed significant reduction in MIC values in their Gnps conjugated form whereas; Gnps conjugated ampicillin showed slight decrement in the MIC value compared to its free form. On the other hand, all of them showed more heat stability in their Gnps conjugated forms. Thus, our findings indicated that Gnps conjugated antibiotics are more efficient and might have significant therapeutic implications

HLA-DQA1*05 carriage associated with development of anti-drug antibodies to infliximab and adalimumab in patients with Crohn's Disease

Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify patients at increased risk for development of anti-drug antibodies would facilitate selection of therapy and use of preventative strategies.This article is freely available via Open Access. Click on Publisher URL to access the full-text

Noise Analysis of Photorefractive Holograms Under Gaussian Beam Illumination

Using a novel transfer function approach, we investigate the nature of the diffracted Gaussian beam from a photorefractive hologram under the influence of noise. The signal-to-noise ratio and spatial fidelity are defined, and their dependence on fringe spacing, temperature and reading beam intensity are discussed