Pseudomechanics of supersymmetric oscillators

In this note, we study some classical aspects of supersymmetric oscillators, in one and two spatial (bosonic) dimensions. Our main ingredient is a generalized Poisson bracket, which emerges as a classical counterpart to commutators and anticommutators from supersymmetric quantum mechanics. In one dimension, i.e. in presence of one bosonic and one fermionic coordinate, the Hamiltonian admits a $U(1,1)$ symmetry for which we explicitly compute the first integrals. It is found that the supercharges emerge from the formalism in a natural way as fermionic conserved quantities. Following this, we describe classical supercharge operators based on the generalized Poisson bracket, which define supersymmetry transformations. The results are generalized to two spatial dimensions, where there is a $U(2,2)$ symmetry in the Hamiltonian. We comment on supersymmetric generalizations of the Pais-Uhlenbeck and isotonic oscillators. The possibility of defining a generalized Nambu bracket in this framework is also discussed

Constraining extra dimensions using observations of black hole quasi-normal modes

The presence of extra dimensions generically modify the spacetime geometry of a rotating black hole, by adding an additional hair, besides the mass $M$ and the angular momentum $J$, known as the `tidal charge' parameter, $\beta$. In a braneworld scenario with one extra spatial dimension, the extra dimension is expected to manifest itself through -- (a) negative values of $\beta$, and (b) modified gravitational perturbations. This in turn would affect the quasi-normal modes of rotating black holes. We numerically solve the perturbed gravitational field equations using the continued fractions method and determine the quasi-normal mode spectra for the braneworld black hole. We find that increasingly negative values of $\beta$ correspond to a diminishing imaginary part of the quasi-normal mode, or equivalently, an increasing damping time. Using the publicly available data of the properties of the remnant black hole in the gravitational wave signal GW150914, we check for consistency between the predicted values (for a given $\beta$) of the frequency and damping time of the least-damped $\ell=2,m=2$ quasi-normal mode and measurements of these quantities using other independent techniques. We find that it is highly unlikely for the tidal charge, $\beta \lesssim -0.05$, providing a conservative limit on the tidal charge parameter. Implications and future directions are discussed.Comment: 11 pages, 2 figures, 1 table, Revised version accepted in EPJ

Mahadevi Varma Narrative Analysis in Hindi Literature

Aim: Mahadevi Varma made the conscious decision to lead a nun's existence in her private life, yet she showed bravery in revealing female sexuality in her poetry. By exposing the physical and psychological abuse perpetrated on women, she rejected her society. Material and method: Her delicate and outstanding use of language and imagery lovingly covered her risky issues. This essay focuses on how Varma overcame the challenges that women faced in her society by abstaining from sexual activity, engaging in resistance to colonialism, and providing for the underprivileged. Statistics and Result: She was an accomplished painter and translator. Despite having liberal beliefs, she was respected in her conservative community due to the self-made career she had achieved

Introduction to Community Service-Learning (SRCL 1000)

Introduction to Community Service-Learning is a general elective open to first to fourth year international and domestic students from a variety of disciplines across campus. Every fall and winter semester each student volunteers at one of 30 local not-for-profit organizations for a full semester. Students are required to complete 24 hours of service as part of their course work. In this poster session, 16 not-for-profit organizations will be represented by 27 SRCL 1000 students. They will demonstrate personal reflections on their service experiences, how their experiences connect to the course work and their organizations, and what they will take back to their own communities after the course is over. Students representing the following Kamloops not-for-profit organizations: Active Care Services: Nolan Fenrich St. John Ambulance: Damilola Abiyo and Ryuki Furuta Overlander Residential Care: Glory Amukamara Ponderosa Lodge: Rahab Kariuki The Kamloops Food Bank: Yu Cao, Surkamal Singh Jhand, Xiangzhong Kong and Ruotong Shi The ReStore – Habitat for Humanity: Dion Maborekhe, Fengyi Yang and Haonan Deng Kamloops Immigrant Services: Dipak Parmar Maple Leaf School: Qian Wang and Mengyao Zhu BC SPCA: Dawei Xu TRU Sustainability Office: Akash Ghosh, Takaya Hirose, Jihoon Kim and Kosuke Masunaga TRU Horticulture: Ols Buta TRU The X Radio: Marie Gabriela Jimenez and MD Majharul Islam Sabuj Beattie School of the Arts: Makoto Iida Gemstone Care Center: Tirth Panchal Chartwell Ridgepointe: Sakina Shikama Sikh Temple: Gurpreet Pua

FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation

Summary: FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in the nucleus. C/D box snoRNAs guide 2’O methylations of ribosomal RNA (rRNA) on defined sites, and this modification regulates rRNA folding and assembly of ribosomes. 2’O methylation of rRNA is partial on several sites in human embryonic stem cells, which results in ribosomes with differential methylation patterns. FMRP-snoRNA interaction affects rRNA methylation on several of these sites, and in the absence of FMRP, differential methylation pattern of rRNA is significantly altered. We found that FMRP recognizes ribosomes carrying specific methylation patterns on rRNA and the recognition of methylation pattern by FMRP may potentially determine the translation status of its target mRNAs. Thus, FMRP integrates its function in the nucleus and in the cytoplasm. : Molecular Interaction; Stem Cells Research; Omics Subject Areas: Molecular Interaction, Stem Cells Research, Omic

Target specific inhibition of West Nile virus envelope glycoprotein and methyltransferase using phytocompounds: an in silico strategy leveraging molecular docking and dynamics simulation

Mosquitoes are the primary vector for West Nile virus, a flavivirus. The virus’s ability to infiltrate and establish itself in increasing numbers of nations has made it a persistent threat to public health worldwide. Despite the widespread occurrence of this potentially fatal disease, no effective treatment options are currently on the market. As a result, there is an immediate need for the research and development of novel pharmaceuticals. To begin, molecular docking was performed on two possible West Nile virus target proteins using a panel of twelve natural chemicals, including Apigenin, Resveratrol, Hesperetin, Fungisterol, Lucidone, Ganoderic acid, Curcumin, Kaempferol, Cholic acid, Chlorogenic acid, Pinocembrin, and Sanguinarine. West Nile virus methyltransferase (PDB ID: 2OY0) binding affinities varied from −7.4 to −8.3 kcal/mol, whereas West Nile virus envelope glycoprotein affinities ranged from −6.2 to −8.1 kcal/mol (PDB ID: 2I69). Second, substances with larger molecular weights are less likely to be unhappy with the Lipinski rule. Hence, additional research was carried out without regard to molecular weight. In addition, compounds 01, 02, 03, 05, 06, 07, 08, 09, 10 and 11 are more soluble in water than compound 04 is. Besides, based on maximum binding affinity, best three compounds (Apigenin, Curcumin, and Ganoderic Acid) has been carried out molecular dynamic simulation (MDs) at 100 ns to determine their stability. The MDs data is also reported that these mentioned molecules are highly stable. Finally, advanced principal component analysis (PCA), dynamics cross-correlation matrices (DCCM) analysis, binding free energy and dynamic cross correlation matrix (DCCM) theoretical study is also included to established mentioned phytochemical as a potential drug candidate. Research has indicated that the aforementioned natural substances may be an effective tool in the battle against the dangerous West Nile virus. This study aims to locate a bioactive natural component that might be used as a pharmaceutical