6 research outputs found
The role of estrogen and progesterone, administered alone and in combination, in modulating cytokine concentration following traumatic brain injury
Cytokines play an important role in the pathophysiology of traumatic brain injury (TBI). This study was designed
to determine the effects of administering progesterone (P) and estrogen (E), alone and in combination, on brain
water content, blood–brain barrier (BBB) disturbance, and brain level of cytokines following diffuse TBI. Ovariectomized
rats were divided into 9 groups, treated with vehicle, E1, E2, P1, P2, E1+P1, E1+P2, E2+P1, and E2+P2. Levels of BBB
disruption (5 h), cytokines, and water content (24 h) were evaluated after TBI induced by the Marmarou method. Physiological
(E1 and P1) and pharmacological (E2 and P2) doses of estrogen and progesterone were administered 30 min after
TBI. Water content in the E1+P2-treated group was higher than in the E1-treated group. The inhibitory effect of E2 on
water content was reduced by adding progesterone. The inhibitory effect of E1 and E2 on Evans blue content was reduced
by treatment with E1+P1 and E2+P2, respectively. The brain level of IL-1b was reduced in E1 and E2, after TBI. In the
E2+P2-treated group, this level was higher than in the E2-treated group. The brain level of TGF-b was also elevated by
the administration of progesterone and estrogen alone, and reduced when the hormones were administered in combination.
In conclusion, a combined administration of progesterone and estrogen inhibited the decreasing effects of administration of
progesterone and estrogen alone on water content and BBB disruption that mediated to change the proinflammatory cytokines
Bushehr Elderly Health (BEH) Programme, phase I (cardiovascular system)
Purpose: The main objective of the Bushehr Elderly
Health Programme, in its first phase, is to investigate
the prevalence of cardiovascular risk factors and their
association with major adverse cardiovascular events.
Participants: Between March 2013 and October
2014, a total of 3000 men and women aged
≥60 years, residing in Bushehr, Iran, participated in
this prospective cohort study ( participation
rate=90.2%).
Findings to date: Baseline data on risk factors,
including demographic and socioeconomic status,
smoking and medical history, were collected through a
modified WHO MONICA questionnaire. Vital signs and
anthropometric measures, including systolic and
diastolic blood pressure, weight, height, and waist and
hip circumference, were also measured. 12-lead
electrocardiography and echocardiography were
conducted on all participants, and total of 10 cc
venous blood was taken, and sera was separated and
stored at –80°C for possible future use. Preliminary
data analyses showed a noticeably higher prevalence of
risk factors among older women compared to that in
men.
Future plans: Risk factor assessments will be
repeated every 5 years, and the participantswill be
followed during the study to measure the occurrence
of major adverse cardiac events. Moreover, the second
phase, which includes investigation of bone health and
cognition in the elderly, was started in September
2015. Data are available at the Persian Gulf Biomedical
Research Institute, Bushehr University of Medical
Sciences, Bushehr, Iran, for any collaboratio
Prevalence of dyslipidemia and its association with other coronary artery disease risk factors among urban population in Southeast of Iran: results of the Kerman coronary artery disease risk factors study (KERCADRS).
BackgroundDespite the importance of identifying and screening dyslipidemia to prevent coronary artery diseases CAD(Coronary Artery Disease), little information is available on dyslipidemia in our large area. So the present study aimed to assess the management status of lipid abnormalities and its association with other CAD risk factors in an urban population of southeast of Iran.MethodsThis cross-sectional study was a part of the Kerman coronary artery disease risk factor study KERCADRS (Kerman coronary artery disease risk study) as a population-based, epidemiological research among 5900 individuals aged 15 to 75 years who were residents of Kerman city, the largest city in Southeast of Iran. Lipid profile was assessed using enzymatic laboratory methods.ResultsIn total, 5558 persons from 5899 participants were assessed in whom 45.1 % were male and 54.9 % female. Overall 20.9 % had borderline level of cholesterol (200-239 mg/dl) and 8.7 % suffered from hypercholesterolemia (≥240 mg/dl). The prevalence of undiagnosed dyslipidemia (UDL) was 16.8 % and of diagnosed dyslipidemia (DDL) was 13.2 % that both UDL and DDL were more prevalent in women. Also, UDL was more revealed in third and fourth age decades. Advanced age, anxiety, obesity (BMI ≥30 Kg/m2), and family history of dyslipidemia predicted dyslipidemia in study population.ConclusionThe overall prevalence of UDL was higher than of DDL, and was significantly influenced by advanced age, anxiety, obesity, and family history of dyslipidemia. The data showed that our health care management system should improve its strategies to reduce the burden of this important CAD risk factor
The effect of aqueous extract of Rosa damascena on formaldehyde-induced toxicity in mice testes
Context: Rosa damascena L. (Rosaceae) (RD) essential oil and extracts are commonly used as a flavour in herbal medicine which increase libido. Previous studies have shown inhalation of RD flower’s oil increases libido and causes protective effects in formaldehyde (FA)-induced testicular damage. Objective: The protective effects of aqueous extract of RD on the male reproductive system of mice were examined following FA-induced damage. Materials and methods: Forty-eight adult NMRI male mice were randomly assigned to six groups (n = 8): control (normal saline, 10 mg/kg); RD40 (40 mg/kg, p.o.); FA treated (10 mg/kg of 10%, i.p.) and FA + RD treated at 10, 20 and 40 mg/kg (FA + RD10), (FA + RD20) and (FA + RD40), respectively, for 40 days. At the end of treatment regimes, serum testosterone (T) level and the reproductive activity, viz. body/organ weights, testicular structure and sperm characteristics were studied. Results: Formaldehyde administration significantly decreased serum T level (p < 0.001), testicular weight/volume, tubular diameter and sperm characteristics compared to the control group (p < 0.05). RD (40 mg/kg) administration in FA-treated mice significantly improved serum T level, testicular weight/histological structure, tubular diameter, Leydig cell number and epididymal sperm characteristics in comparison to its lower doses and the control group (p < 0.05). Discussion and conclusions: We may conclude that RD flower extract can withstand effects of FA in the male reproductive system of mice possibly due to its antioxidative properties