1,032 research outputs found
Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study
<p>Abstract</p> <p>Background</p> <p>Lung injury caused by both inhaled dusts and infectious agents depends on increased availability of iron and metal-catalyzed oxidative stress. Because inhaled particles, such as silica, and certain infections can cause secondary pulmonary alveolar proteinosis (PAP), we tested the hypothesis that idiopathic PAP is associated with an altered iron homeostasis in the human lung.</p> <p>Methods</p> <p>Healthy volunteers (n = 20) and patients with idiopathic PAP (n = 20) underwent bronchoalveolar lavage and measurements were made of total protein, iron, tranferrin, transferrin receptor, lactoferrin, and ferritin. Histochemical staining for iron and ferritin was done in the cell pellets from control subjects and PAP patients, and in lung specimens of patients without cardiopulmonary disease and with PAP. Lavage concentrations of urate, glutathione, and ascorbate were also measured as indices of oxidative stress.</p> <p>Results</p> <p>Lavage concentrations of iron, transferrin, transferrin receptor, lactoferrin, and ferritin were significantly elevated in PAP patients relative to healthy volunteers. The cells of PAP patients had accumulated significant iron and ferritin, as well as considerable amounts of extracellular ferritin. Immunohistochemistry for ferritin in lung tissue revealed comparable amounts of this metal-storage protein in the lower respiratory tract of PAP patients both intracellularly and extracellularly. Lavage concentrations of ascorbate, glutathione, and urate were significantly lower in the lavage fluid of the PAP patients.</p> <p>Conclusion</p> <p>Iron homeostasis is altered in the lungs of patients with idiopathic PAP, as large amounts of catalytically-active iron and low molecular weight anti-oxidant depletion are present. These findings suggest a metal-catalyzed oxidative stress in the maintenance of this disease.</p
Precise Measurement of Sigma Beam Asymmetry for Positive Pion Photoproduction on the Proton from 800 to 1500 Mev
The Sigma beam asymmetry for positive pion photoproduction on the proton has
been measured over an angular range of 40-170 deg at photon energies from 0.8
to 1.5 GeV. The resulting data set includes 237 accurate points, 136 of these
belonging to an almost unexplored domain above 1.05 GeV. Data of such high
precision provide severe constraints for partial wave analyses. The influence
of this experiment on the GW multipole analysis is demonstrated. Significant
changes are found in multipoles connected to the S31(1620) and P13(1720)
resonances. Comparisons using the MAID analysis are also presented.Comment: 11 pages, 4 eps figures. to be published in Physics Letters
Shedding New Light on Kaon-Nucleon/Nuclei Interaction and Its Astrophysical Implications with the AMADEUS Experiment at DAFNE
The AMADEUS experiment deals with the investigation of the low-energy
kaon-nuclei hadronic interaction at the DA{\Phi}NE collider at LNF-INFN, which
is fundamental to respond longstanding questions in the non-perturbative QCD
strangeness sector. The antikaon-nucleon potential is investigated searching
for signals from possible bound kaonic clusters, which would open the
possibility for the formation of cold dense baryonic matter. The confirmation
of this scenario may imply a fundamental role of strangeness in astrophysics.
AMADEUS step 0 consisted in the reanalysis of 2004/2005 KLOE dataset,
exploiting K- absorptions in H, 4He, 9Be and 12C in the setup materials. In
this paper, together with a review on the multi-nucleon K- absorption and the
particle identification procedure, the first results on the {\Sigma}0-p channel
will be presented including a statistical analysis on the possible accomodation
of a deeply bound stateComment: 6 pages, 2 figure, 1 table, HADRON 2015 conferenc
Eta photoproduction on the neutron at GRAAL: Measurement of the differential cross section
In this contribution, we will present our first preliminary measurement of
the differential cross section for the reaction gamma+n->eta+n. Comparison of
the reactions gamma+p->eta+p for free and bound proton (D2 target) will also be
discussed.Comment: 6 pages, 4 figures, Proceedings of the 10th International Symposium
on Meson-Nucleon Physics and the Structure of the Nucleon, August
29-September 4 2004, Beijing, Chin
Vertically-Aligned Functionalized Silicon Micropillars for 3D Culture of Human Pluripotent Stem Cell-Derived Cortical Progenitors
Silicon is a promising material for tissue engineering since it allows to produce micropatterned scaffolding structures resembling biological tissues. Using specific fabrication methods, it is possible to build aligned 3D network-like structures. In the present study, we exploited vertically-aligned silicon micropillar arrays as culture systems for human iPSC-derived cortical progenitors. In particular, our aim was to mimic the radially-oriented cortical radial glia fibres that during embryonic development play key roles in controlling the expansion, radial migration and differentiation of cortical progenitors, which are, in turn, pivotal to the establishment of the correct multilayered cerebral cortex structure. Here we show that silicon vertical micropillar arrays efficiently promote expansion and stemness preservation of human cortical progenitors when compared to standard monolayer growth conditions. Furthermore, the vertically-oriented micropillars allow the radial migration distinctive of cortical progenitors in vivo. These results indicate that vertical silicon micropillar arrays can offer an optimal system for human cortical progenitors' growth and migration. Furthermore, similar structures present an attractive platform for cortical tissue engineering
Lowering the Light Speed Isotropy Limit: European Synchrotron Radiation Facility Measurements
The measurement of the Compton edge of the scattered electrons in GRAAL
facility in European Synchrotron Radiation Facility (ESRF) in Grenoble with
respect to the Cosmic Microwave Background dipole reveals up to 10 sigma
variations larger than the statistical errors. We now show that the variations
are not due to the frequency variations of the accelerator. The nature of
Compton edge variations remains unclear, thus outlining the imperative of
dedicated studies of light speed anisotropy
Eta photoproduction off the neutron at GRAAL: Evidence for a resonant structure at W=1.67 GeV
New (preliminary) data on eta photoproduction off the neutron are presented.
These data reveal a resonant structure at W=1.67 GeV.Comment: 8 pages, 4 figures. Published in Proceedings of Workshop on the
Physics of Excited Nucleons NSTAR2004, Grenoble, France, March 24 - 27,
pg.19
Unprecedented studies of the low-energy negatively charged kaons interactions in nuclear matter by AMADEUS
The AMADEUS experiment aims to provide unique quality data of hadronic
interactions in light nuclear targets, in order to solve fundamental open
questions in the non-perturbative strangeness QCD sector, like the
controversial nature of the state, the yield of hyperon
formation below threshold, the yield and shape of multi-nucleon
absorption, processes which are intimately connected to the possible existence
of exotic antikaon multi-nucleon clusters. AMADEUS takes advantage of the
DANE collider, which provides a unique source of monochromatic
low-momentum kaons and exploits the KLOE detector as an active target, in order
to obtain excellent acceptance and resolution data for nuclear capture on
H, He, Be and C, both at-rest and in-flight. During the
second half of 2012 a successful data taking was performed with a dedicated
pure carbon target implemented in the central region of KLOE, providing a high
statistic sample of pure at-rest nuclear interactions. For the future
dedicated setups involving cryogenic gaseous targets are under preparation.Comment: 14 pages, 6 figure
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