Integration of Expectation Maximization using Gaussian Mixture Models and Naïve Bayes for Intrusion Detection

Intrusion detection is the investigation process of information about the system activities or its data to detect any malicious behavior or unauthorized activity. Most of the IDS implement K-means clustering technique due to its linear complexity and fast computing ability. Nonetheless, it is Naïve use of the mean data value for the cluster core that presents a major drawback. The chances of two circular clusters having different radius and centering at the same mean will occur. This condition cannot be addressed by the K-means algorithm because the mean value of the various clusters is very similar together. However, if the clusters are not spherical, it fails. To overcome this issue, a new integrated hybrid model by integrating expectation maximizing (EM) clustering using a Gaussian mixture model (GMM) and naïve Bays classifier have been proposed. In this model, GMM give more flexibility than K-Means in terms of cluster covariance. Also, they use probabilities function and soft clustering, that’s why they can have multiple cluster for a single data. In GMM, we can define the cluster form in GMM by two parameters: the mean and the standard deviation. This means that by using these two parameters, the cluster can take any kind of elliptical shape. EM-GMM will be used to cluster data based on data activity into the corresponding category

Assesment of electricity excess in an isolated hybrid energy system: A case study of a Dangiwada village in rural Nepal

The increasing demand of power can be fulfilled through different architectures and electricity supply models by utilizing the available local resources. But most of the isolated energy system suffers from high energy cost and unreliable energy supply. This study identifies different electricity supply models to fulfill the dynamic demand of power in a remote area, which is analyzed in terms of cost of energy and causes for the high cost of energy. Among different factors, the presence of unusable energy (Electricity Excess) produced by the energy system during fulfillment of the demand is found to be major one cause for the high cost of energy. Further, the importance of energy storage system in isolated energy system is discussed. In this case, up to 83.4 % of electricity excess is observed, which can be utilized in different manners to reduce the total energy cost. Electricity excess profile for different energy model, their impacts and possible techniques of the solution with open views are discussed

Optimizing biological nitrogen fixation inexpensively as part of a sustainable agriculture kit (SAK) strategy to assist subsistence farmers

PowerPoint presentationThis work was carried out with the aid of a grant from Canada’s International Development Research Centre (IDRC), and with financial support from the Government of Canada, provided through Global Affairs Canada (GAC)This PowerPoint presentation shows how Symbiotic Nitrogen Fixation (SNF) works in plants and soils, and how it can be improved to help smallholder farmers through identification practices. A newly developed biosensor “GlnLux biosensor” measures SNF output in non-transgenic ureide- and amide-exporting legumes. This process can efficiently measure nitrogen fixation capabilities of legume crop varieties. Also part of the presentation are low cost tools and methods of planting, provided as visual instructions for smallholder participants in field trials, as well as Sustainable Agriculture Kit (SAK) tests and demonstrations

SARS-CoV-2 Mac1 is an essential virulence factor

Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein. Utilizing point mutant recombinant viruses, Mac1 was shown to be critical for both murine hepatitis virus (MHV) and severe acute respiratory syndrome (SARS)-CoV virulence. However, as a potential drug target, it is imperative to understand how a complete Mac1 deletion impacts the replication and pathogenesis of different CoVs. To this end, we created recombinant bacterial artificial chromosomes (BACs) containing complete Mac1 deletions (ΔMac1) in MHV, MERS-CoV, and SARS-CoV-2. While we were unable to recover infectious virus from MHV or MERS-CoV ΔMac1 BACs, SARS-CoV-2 ΔMac1 was readily recovered from BAC transfection, indicating a stark difference in the requirement for Mac1 between different CoVs. Furthermore, SARS-CoV-2 ΔMac1 replicated at or near wild-type levels in multiple cell lines susceptible to infection. However, in a mouse model of severe infection, ΔMac1 was quickly cleared causing minimal pathology without any morbidity. ΔMac1 SARS-CoV-2 induced increased levels of interferon (IFN) and interferon-stimulated gene (ISG) expression in cell culture and mice, indicating that Mac1 blocks IFN responses which may contribute to its attenuation. ΔMac1 infection also led to a stark reduction in inflammatory monocytes and neutrophils. These results demonstrate that Mac1 only minimally impacts SARS-CoV-2 replication, unlike MHV and MERS-CoV, but is required for SARS-CoV-2 pathogenesis and is a unique antiviral drug target.National Institutes of Health (NIH) grant P20GM103648 (RC) National Institutes of Health (NIH) grant 2P01AI060699 (LE) National Institutes of Health (NIH) grant P20GM113117 (ARF) National Institutes of Health (NIH) grant K22AI134993 (ARF) National Institutes of Health (NIH) grant R35GM138029 (ARF) National Science Foundation (NSF) grant 2135167 (RLU) University of Kansas General Research Fund (GRF) and Start-up funds (ARF) NIH Graduate Training at the Biology-Chemistry Interface grant T32GM132061 (CMK) University of Kansas College of Liberal Arts and Sciences Graduate Research Fellowship (CMK) Government of Spain (PID2019-107001RB-I00 AEI/FEDER, UE) LE European Commission (H2020-SC1-2019, ISOLDA Project nº 848166-2) LEN

Routine Measurement of Serum Amylase in Acute Abdomen

Introduction: Acute abdominal pain is a common condition presenting to both the emergency department and surgical admission unit. Increase in serum amylase levels are found in much gastrointestinal pathology. Serum amylase level is consistently high in acute pancreatitis though high values are not pathognomonic of pancreatitis .The aim of this study to assess the level of serum amylase in various diseases presenting with acute abdominal pain and to evaluate the role of routine measurement of serum amylase in the screening of patient with acute abdominal pain for the diagnosis of acute pancreatitis in a prospective series. Methods: A prospective observational study was performed from 15th May 2014 – 15th Nov 2014 (6 months) at Department of Surgery of Kathmandu medical College Teaching Hospital; Kathmandu. All consecutive patients presented at emergency department and required admissions in surgical ward were included. A multivariate analysis was performed to assess the level of serum amylase in various diseases presenting with acute abdominal pain including acute pancreatitis. Results: Overall, 318 patients were included during a period of 6 months among them 48 patients were excluded. 34 cases (12.6 %) were diagnosed of acute pancreatitis. three cases (1.1%) of non pancreatic pathology with raised serum amylase level (> 1000 U\L). Conclusions: Routine assessment of serum amylase is helpful in excluding differential diagnosis of patient presenting with acute abdomen and this study identified serum amylase as a good screening tool if done in cases with clinical suspicion.  Keywords: acute abdominal pain; acute pancreatitis; serum amylase

Yam on terrace walls valuing underutilised crops, Annex 16

Local Initiatives for Biodiversity, Research and Development (LI-BIRD) in partnership with scholars from University of Guelph, and Canadian Mennonite University and funded by International Development Research Centre (IDRC) and Global Affairs Canada (GAC), Canada is trying to promote the use of barren and steep walls of the terraces and other areas which are least used for food production.This publication received funding from the International Development Research Centre (IDRC) and Global Affairs Canada (GAC), Canada.A report of Nepal Chepang Association (NCA) suggests that 71% of the children are malnourished. Non-toxic wild yam of Nepal is recognized as ‘Health/ Functional food’ with high nutritional values. Rich in starch, yam is principal source of food and carbohydrate during food insufficiency periods for such communities. Some of the species of yam reported to have 5 times more protein than potatoes and sweet potatoes. Yam also supplements many dietary minerals. Yam can be mixed with different kinds of food like noodles and breads, which further enhances the nutritional value and palatability ultimately aiding to overcome malnutrition in children

Delayed onset serotonin syndrome in the setting of polypharmacy

Serotonin syndrome is a rare but well-known condition that can be life-threatening if not diagnosed early. Onset is usually within 4 to 13 h of starting the offending medication. We present a case of delayed onset of serotonin syndrome that presented after 48 h. Polypharmacy played a role in causing the onset of symptoms. Clinicians should keep a high index of suspicion for serotonin syndrome when dealing with elderly confused patients who take multiple medications even when the onset is delayed or atypical because the outcome can be disastrous

Isolated Mesenteric Tuberculosis

<div><div>Abdominal tuberculosis is common in developing world, and abdominal tuberculosis is most common presentation of extra pulmonary tuberculosis. High index of suspicion is needed in patient from endemic are with chronic abdominal pain and constitutional symptom for diagnosis of abdominal tuberculosis. In abdominal tuberculosis although intestinal, cecal and lymph node involvement are common, isolated mesenteric tuberculosis is rare presentation and very few cases has been reported. Here we are presenting rare case of a young male with isolated mesenteric tuberculosis who presented with abdominal mas.</div><div> Key words: Abdominal mass, Mesenteric, tuberculosis</div><div><br></div></div><div><div><div><div><div><div></div><div></div></div></div></div></div></div