1,085 research outputs found
Quantifier-Free Interpolation of a Theory of Arrays
The use of interpolants in model checking is becoming an enabling technology
to allow fast and robust verification of hardware and software. The application
of encodings based on the theory of arrays, however, is limited by the
impossibility of deriving quantifier- free interpolants in general. In this
paper, we show that it is possible to obtain quantifier-free interpolants for a
Skolemized version of the extensional theory of arrays. We prove this in two
ways: (1) non-constructively, by using the model theoretic notion of
amalgamation, which is known to be equivalent to admit quantifier-free
interpolation for universal theories; and (2) constructively, by designing an
interpolating procedure, based on solving equations between array updates.
(Interestingly, rewriting techniques are used in the key steps of the solver
and its proof of correctness.) To the best of our knowledge, this is the first
successful attempt of computing quantifier- free interpolants for a variant of
the theory of arrays with extensionality
Assessing the relative accuracy of coral heights reconstructed from drones and structure from motion photogrammetry on coral reefs
Low-altitude high-resolution aerial photographs allow for the reconstruction of structural properties of shallow coral reefs and the quantification of their topographic complexity. This study shows the scope and limitations of two-media (air/water) Structure from Motion—Multi-View Stereo reconstruction method using drone aerial photographs to reconstruct coral height. We apply this method in nine different sites covering a total area of about 7000 m2, and we examine the suitability of the method to obtain topographic complexity estimates (i.e., seafloor rugosity). A simple refraction correction and survey design allowed reaching a root mean square error of 0.1 m for the generated digital models of the seafloor (without the refraction correction the root mean square error was 0.2 m). We find that the complexity of the seafloor extracted from the drone digital models is slightly underestimated compared to the one measured with a traditional in situ survey method
Statistical properties of classical gravitating particles in (2+1) dimensions
We report the statistical properties of classical particles in (2+1) gravity
as resulting from numerical simulations. Only particle momenta have been taken
into account. In the range of total momentum where thermal equilibrium is
reached, the distribution function and the corresponding Boltzmann entropy are
computed. In the presence of large gravity effects, different extensions of the
temperature turn out to be inequivalent, the distribution function has a power
law high-energy tail and the entropy as a function of the internal energy
presents a flex. When the energy approaches the open universe limit, the
entropy and the mean value of the particle kinetic energy seem to diverge.Comment: Latex2e (amssymb) file, 17 page
Unexpected thymoma in a challenging case of hyperparathyroidism
We report the case of a woman with primary hyperparathyroidism suspected of mediastinal ectopic parathyroid adenoma revealed to be a thymoma. Our aim was to
focus on some possible criticisms in distinguishing between ectopic parathyroid and
thymus
Bioreactor With Electrically Deformable Curved Membranes for Mechanical Stimulation of Cell Cultures.
Physiologically relevant in vitro models of stretchable biological tissues, such as muscle, lung, cardiac and gastro-intestinal tissues, should mimic the mechanical cues which cells are exposed to in their dynamic microenvironment in vivo. In particular, in order to mimic the mechanical stimulation of tissues in a physiologically relevant manner, cell stretching is often desirable on surfaces with dynamically controllable curvature. Here, we present a device that can deform cell culture membranes without the current need for external pneumatic/fluidic or electrical motors, which typically make the systems bulky and difficult to operate. We describe a modular device that uses elastomeric membranes, which can intrinsically be deformed by electrical means, producing a dynamically tuneable curvature. This approach leads to compact, self-contained, lightweight and versatile bioreactors, not requiring any additional mechanical equipment. This was obtained via a special type of dielectric elastomer actuator. The structure, operation and performance of early prototypes are described, showing preliminary evidence on their ability to induce changes on the spatial arrangement of the cytoskeleton of fibroblasts dynamically stretched for 8 h
What's Decidable About Sequences?
We present a first-order theory of sequences with integer elements,
Presburger arithmetic, and regular constraints, which can model significant
properties of data structures such as arrays and lists. We give a decision
procedure for the quantifier-free fragment, based on an encoding into the
first-order theory of concatenation; the procedure has PSPACE complexity. The
quantifier-free fragment of the theory of sequences can express properties such
as sortedness and injectivity, as well as Boolean combinations of periodic and
arithmetic facts relating the elements of the sequence and their positions
(e.g., "for all even i's, the element at position i has value i+3 or 2i"). The
resulting expressive power is orthogonal to that of the most expressive
decidable logics for arrays. Some examples demonstrate that the fragment is
also suitable to reason about sequence-manipulating programs within the
standard framework of axiomatic semantics.Comment: Fixed a few lapses in the Mergesort exampl
Bioreactor With Electrically Deformable Curved Membranes for Mechanical Stimulation of Cell Cultures
Physiologically relevant in vitro models of stretchable biological tissues, such as muscle, lung, cardiac and gastro-intestinal tissues, should mimic the mechanical cues which cells are exposed to in their dynamic microenvironment in vivo. In particular, in order to mimic the mechanical stimulation of tissues in a physiologically relevant manner, cell stretching is often desirable on surfaces with dynamically controllable curvature. Here, we present a device that can deform cell culture membranes without the current need for external pneumatic/fluidic or electrical motors, which typically make the systems bulky and difficult to operate. We describe a modular device that uses elastomeric membranes, which can intrinsically be deformed by electrical means, producing a dynamically tuneable curvature. This approach leads to compact, self-contained, lightweight and versatile bioreactors, not requiring any additional mechanical equipment. This was obtained via a special type of dielectric elastomer actuator. The structure, operation and performance of early prototypes are described, showing preliminary evidence on their ability to induce changes on the spatial arrangement of the cytoskeleton of fibroblasts dynamically stretched for 8 h
Pathophysiology and medical treatment of pain in fibrous dysplasia of bone
One of the most common complications of fibrous dysplasia of bone (FD) is bone pain. Usual pain killers are often of inadequate efficacy to control this bone pain. The mechanism of bone pain in FD remains uncertain, but by analogy with bone tumors one may consider that ectopic sprouting and formation of neuroma-like structures by sensory and sympathetic nerve fibers also occur in the dysplastic skeleton. Bone pain has been reported in up to 81% of adults and 49% of children. It affects predominantly the lower limbs and the spine. The degree of pain is highly variable and adults reports more pain than children. Bisphosphonates have been shown to reduce bone pain in uncontrolled studies. Their influence on bone strength remains unknown. In a randomized trial testing alendronate, bone pain was not significantly improved. Another trial assessing the effect of risedronate is ongoing. Possible future therapies include tocilizumab, denosumab and drugs targeting nerve growth factor and its receptor TrkA
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