1,754 research outputs found
Nanosized patterns as reference structures for macroscopic transport properties and vortex phases in YBCO films
This paper studies the striking correlation between nanosized structural
patterns in YBCO films and macroscopic transport current. A nanosized network
of parallel Josephson junctions laced by insulating dislocations is almost
mimicking the grain boundary structural network. It contributes to the
macroscopic properties and accounts for the strong intergranular pinning across
the film in the intermediate temperature range. The correlation between the two
networks enables to find out an outstanding scaling law in the (Jc,B) plane and
to determine meaningful parameters concerning the matching between the vortex
lattice and the intergranular defect lattice. Two asymptotic behaviors of the
pinning force below the flux flow regime are checked: the corresponding vortex
phases are clearly individuated.Comment: 4 pages, 4 figure
Strong Reduction of the Field-Dependent Microwave Surface Resistance in YBCO with BaZrO_3 Inclusions
We present measurements of the magnetic field dependent microwave surface
resistance in laser-ablated YBaCuO films on SrTiO
substrates. BaZrO crystallites were included in the films using composite
targets containing BaZrO inclusions with mean grain size smaller than 1
m. X-ray diffraction showed single epitaxial relationship between
BaZrO and YBaCuO. The effective surface resistance was
measured at 47.7 GHz for 6090 K and 00.8 T. The magnetic
field had a very different effect on pristine YBaCuO and
YBaCuO/BaZrO, while for 0 only a reduction of
in the YBaCuO/BaZrO film was observed,
consistent with dc measurements. At low enough , in moderate fields
YBaCuO/BaZrO exhibited an intrinsic thin film
resistance lower than the pure film. The results clearly indicate that
BaZrO inclusions determine a strong reduction of the field-dependent
surface resistance. From the analysis of the data in the framework of simple
models for the microwave surface impedance in the mixed state we argue that
BaZrO inclusions determine very steep pinning potentials.Comment: LaTeX, 6 pages, 4 figures, uses jpconf.cls and jpconf11.clo class
files, talk given at EUCAS 2007, submitted to J. Phys.: Conf. Serie
Cygnus X-3 in outburst : quenched radio emission, radiation losses and variable local opacity
We present multiwavelength observations of Cygnus X-3 during an extended
outburst in 1994 February - March. Intensive radio monitoring at 13.3, 3.6 &
2.0 cm is complemented by observations at (sub)millimetre and infrared
wavelengths, which find Cyg X-3 to be unusually bright and variable, and
include the first reported detection of the source at 0.45 mm. We report the
first confirmation of quenched radio emission prior to radio flaring
independent of observations at Green Bank. The observations reveal evidence for
wavelength-dependent radiation losses and gradually decreasing opacity in the
environment of the radio jet. We find that the radiation losses are likely to
be predominantly inverse Compton losses experienced by the radio-emitting
electrons in the strong radiation field of a luminous companion to the compact
object. We interpret the decreasing opacity during the flare sequence as
resulting from a decreasing proportion of thermal electrons entrained in the
jet, reflecting a decreasing density in the region of jet formation. We
present, drawing in part on the work of other authors, a model based upon
mass-transfer rate instability predicting gamma-ray, X-ray, infrared and radio
trends during a radio flaring sequence.Comment: LaTeX, 11 pages, 6 figures. Submitted to MNRA
Dysfunctional inflammation in cystic fibrosis airways: From mechanisms to novel therapeutic approaches
Cystic fibrosis (CF) is an inherited disorder caused by mutations in the gene encoding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein, an ATP-gated chloride channel expressed on the apical surface of airway epithelial cells. CFTR absence/dysfunction results in defective ion transport and subsequent airway surface liquid dehydration that severely compromise the airway microenvironment. Noxious agents and pathogens are entrapped inside the abnormally thick mucus layer and establish a highly inflammatory environment, ultimately leading to lung damage. Since chronic airway inflammation plays a crucial role in CF pathophysiology, several studies have investigated the mechanisms responsible for the altered inflammatory/immune response that, in turn, exacerbates the epithelial dysfunction and infection susceptibility in CF patients. In this review, we address the evidence for a critical role of dysfunctional inflammation in lung damage in CF and discuss current therapeutic approaches targeting this condition, as well as potential new treatments that have been developed recently. Traditional therapeutic strategies have shown several limitations and limited clinical benefits. Therefore, many efforts have been made to develop alternative treatments and novel therapeutic approaches, and recent findings have identified new molecules as potential anti-inflammatory agents that may exert beneficial effects in CF patients. Furthermore, the potential anti-inflammatory properties of CFTR modulators, a class of drugs that directly target the molecular defect of CF, also will be critically reviewed. Finally, we also will discuss the possible impact of SARS-CoV-2 infection on CF patients, with a major focus on the consequences that the viral infection could have on the persistent inflammation in these patients
A new apparatus for deep patterning of beam sensitive targets by means of high-energy ion beam
The paper reports on a high precision equipment designed to modify over
3-dimensions (3D) by means of high-energy gold ions the local properties of
thin and thick films. A target-moving system aimed at creating patterns across
the volume is driven by an x-y writing protocol that allows one to modify beam
sensitive samples over micrometer-size regions of whatever shape. The apparatus
has a mechanical resolution of 15 nm. The issue of the local fluence
measurement has been particularly addressed. The setup has been checked by
means of different geometries patterned on beam sensitive sheets as well as on
superconducting materials. In the last case the 3D modification consists of
amorphous nanostructures. The nanostructures create zones with different
dissipative properties with respect to the virgin regions. The main analysis
method consists of magneto-optical imaging that provides local information on
the electrodynamics of the modified zones. Features typical of non-linear
current flow hint at which pattern geometry is more functional to applications
in the framework of nanostructures across superconducting films.Comment: 7 page
A critical review on the role of food and nutrition in the energy balance
The mass media has increasingly frequently suggested to the general population that specific foods or nutritional schemes are able to affect both human metabolism and energy expenditure, thus facilitating weight loss. This critical review is aimed at assessing available evidence on the roles of nutrients, food and dietary regimens in energy intake and energy expenditure. We queried the National Library of Medicine, the Cochrane Library, Excerpta Medica dataBASEand the Cumulative Index to Nursing and Allied Health Literature database, and a search strategy was performed by using database-specific subject headings and keywords. We found that available scientific evidence on these topics is scarce, and that the limited number of available studies often have poor methodological quality. Only a few foods show beneficial effects on metabolism and energy expenditure, as the human energy balance is complex and multifactorial. Finally, microbiota may interfere with the intake, use and expenditure of energy in the human body. Conclusive evidence is still lacking, and, at present, it is not possible to identify a food or a diet with a significant impact on human energy expenditure
FRI0499 ACROMEGALY ARTROPATHY: IS THERE SOMETHING MORE BEHIND THE PAIN? A CROSS-SECTIONAL STUDY TO EVALUATE RHEUMATIC DISEASE IN GROWTH HORMONE SECRETING TUMOR PATIENTS
Background:Acromegaly is a rare disease with a remarkable impact on patients, both in terms of life expectancy and quality of life. Osteo-articular complications are one of the most frequently reported bothers. The "acromegaly artropathy" characterizes more than 70% of patients at diagnosis. Artropathy affects both spine and peripheral joints. A recent prospective study documented progression of acromegalic arthropathy identified as a worsening of osteophytes and joint space narrowing in 72–74% of patients despite long-term biochemical control. In addiction the Literature has occasionally reported cases of simultaneous presence of rheumatic diseases (rheumatoid arthritis, polymyalgia rheumatica, undifferentiated connective tissue diseases) and acromegaly and in all these cases the treatment has been delayed, because of wrong symptoms attribution to acromegaly artropathy.Objectives:The primary goal of the study is to better characterize joint pain in acromegaly patients and to evaluate the prevalence of rheumatic disease in growth hormone (GH) secreting pituitary tumor patients.Methods:We enrolled 20 acromegaly subjects (AS) and 20 control subjects (CS). In each subject immunological pattern (rheumatoid factor – RF; antinuclear antibodies - ANA, ENA; anti-citrullinated protein antibodies - ACPA; erythrocyte sedimentation rate – ESR) has been evaluated; they, also, underwent bilateral joint ultrasound of hands and wrists and nail capillaroscopy. The Chi square test and the Fisher's exact test were used to evaluate the association between binary variables, while the Spearman's test to evaluate the correlation of continuous ones. A multiple or logistic regression model was calculated in order to define the association between the capillaroscopic alterations and other detected variables.Results:Articular pain emerged as significantly more frequent in AS (p = 0.0269). No statistically significant differences are detected regarding immunological pattern. ANA and ENA screening resulted positive in 10% in AS and in 5% in CS. No IgA ACPA were detected in AS or CS, while IgG ACPA were positive only in one AS subject. No significant differences were detected between IgM and IgG RFin the two groups (AS 5% and CS 0%). Three fold higher IgG FR in AS compared to CS were detected. ESR levels were significantly higher than CS (p = 0.0405), as well as increased power doppler (PWD) articular uptake (AS 30% vs CS 5% p 0.081). The capillaroscopic evaluation showed a significant difference in almost each parameter that has been evaluated (logistic regression: number of enlargement p 0.004, hemorragies p 0.01 and capillaries p 0.001), showing a moderate-severe microangiopathy in AS. Interestingly, analyzing only the acromegaly cohort, we noticed higher GH levels at the enrollment in patients which developed capillary enlargements (GH: 0.95 ng/ml IQ 0,6-1,6) compared to other ones (GH: 0.55 ng/ml IQ 0.4-0.7; p = 0.08) and a significant lower number of hemorrhages (p = 0.02) in patients treated with GH antagonist pegvisomant.Conclusion:Our results demonstrated that joint damage in acromegaly does not seem to have an autoimmune etiology. Therefore, articular damage is mechanical and increased ESR and PWD alterations seems to confirm the presence of an inflammatory component. In addition, acromegaly is characterized by a microvascular pattern of moderate-severe microangiopathy, without correlation to IGF-I, but GH levels. Although requiring further confirmatory studies, our preliminary results seem to indicate how the capillaroscopic examination could be useful to detect earlier microangiopathy and to identify patients with a greater risk of macroangiopathy development..References:[1]Claessen KMJA et al. Bone and joint disorders in acromegaly. Neuroendocrinology. 2016;103(1):86-95.[2]Örük G et al. Is every joint symptom related to acromegaly? Endocrine. 2013 Apr;43(2):404-11.Disclosure of Interests:None declare
- …