Immunologic factors in patients with chronic polypoid sinusitis

Nasal polyposis is the benign protrusion of soft tissue into the nasal cavity, with multifactorial origin. This study is designed to examine the suggested role of IgE and CD4 and CD8 lymphocytes in the pathogenesis of nasal polyposis. Blood samples were taken from 32 patients with chronic polypoid sinusitis and 32 controls. CD4 and CD8 total lymphocyte count were determined by flow cytometry and the level of serum IgE was measured by ELISA. Nasal discharge samples were also collected for determining IgE level in both patients and controls during surgery. In 68.8% of patients a history of allergy was present. The level of nasal discharge IgE was significantly higher (p 0.05). CD8 concentration and blood lymphocytes were significantly higher (

Immunologic factors in patients with chronic polypoid sinusitis

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The effect of hydro-alcoholic extract of celery (Apium graveolens) leaves on serum level of testosterone, FSH and LH in male rats

Background and Objective: Celery (Apium graveolens) is a plant from Apiaceae family with high nutritional and medicinal use.This plant has many phytoestrogens that can affect the pituitary-gonadal axis. The purpose of this study was to investigate the effect of hydro-alcoholic extract of celery leaves on serum level of testosterone, FSH and LH in male rats. Materials and Methods: In this experimental study, thirty-two male wistar rats were randomly divided into four groups of eight rats each. The control group did not receive anything. The sham group received distilled water (as a solvent), and the experimental groups received doses of 200 and 300 mg/kg/ BW of hydro-alcoholic extract of celery leaves for 20 days. The extract was gavaged once a day. One day after the last gavage, the rats were anaesthetized and blood samples were collected from the heart and then serum levels of testosterone, LH and FSH were measured. The data were analyzed using SPSS software and ANOVA test. Results: Concentration of LH in the treatment group with doses of 200 mg/kg (0.39±0.02 mIU/dl) reduced in comparison with control (0.67±0.01 mIU/dl) and sham (0.73±0.02 mIU/dl) groups (P0.05). Conclusion: The results indicated that the administration of 200 mg/kg doses of celery extract causes a significant reduction in serum LH concentration, but it has no effect on ganadotropin and testosterone hormones in highest doses used in this study. This finding may be due to the presence of flavonoid and antioxidant proporties of celery

Acute Effect of One Incremental Exhausting Cycling Session with Hand on the Response of T and NK Cells of Immune System in Student Athletes

Introduction: Various sorts of physical activites cause various changes in body immune system. The purpose of this study was to examine the acute effect of one incremental exhausting cycling session with hand on the response of T and NK cells of immune system of male physical education students. Methods: In this study, twenty male subjects with mean age of 22.4±1.8(SD) years, mean Vo2 max 41.7±7.1(SD) ml/kg/min and mean BMI 23±1.87(SD) kg/m2 were divided randomly into control(n=10) and experimental group(n=10). The subjects of experimental group performed Sawaka. Protocol, whereas the subjects of control group did not participate in any exercise activity. Blood samples were taken from brachial vein of control and experimental subjects during pre-test, post-test and two hours after the end of exercise. For analysis of statistical data, t-independent and t-correlated tests ( =0.05 significant) were used. Results: Immediately after training, the percentage of CD8 (T) and CD16.56 (NK) cells increased significantly (P≤0.005, P≤0.001). On the other hand, the ratio of CD4/CD8 cells and the percentage of CD4 (T) cells showed significant decrease (P≤0.002, P≤0.001). In addition, the percentage of CD56 and CD16 (NK) cells did not change significantly. It is worth mentioning that these changes after two hours returned to the normal state at the end of the sport test (P≤0.251, P≤0.229). Conclusion: One acute training session with hand causes both increase and decrease in T and NK cells of immune system function. But, these changes are temporary and return back to normal levels within a few hours