The role of institutional characteristics in knowledge transfer: a comparative analysis of two Italian universities

Book synopsis: Universities have become essential players in the generation of knowledge and innovation. Through the commercialization of technology, they have developed the ability to influence regional economic growth. By examining different commercialization models this book analyses technology transfer at universities as part of a national and regional system. It provides insight as to why certain models work better than others, and reaffirms that technology transfer programs must be linked to their regional and commercial environments. Using a global perspective on technology commercialization, this book divides the discussion between developed and developing counties according to the level of university commercialization capability. Critical cases as well as country reports examine the policies and culture of university involvement in economic development, relationships between university and industry, and the commercialization of technology first developed at universities. In addition, each chapter provides examples from specific universities in each country from a regional, national, and international comparative perspective. This book includes articles by leading practitioners as well as researchers and will be highly relevant to all those with an interest in innovation studies, organizational studies, regional economics, higher education, public policy and business entrepreneurship

Calibration of the stereological estimation of the number of myelinated axons in the rat sciatic nerve: a multicenter study.

Several sources of variability can affect stereological estimates. Here we measured the impact of potential sources of variability on numerical stereological estimates of myelinated axons in the adult rat sciatic nerve. Besides biological variation, parameters tested included two variations of stereological methods (unbiased counting frame versus 2D-disector), two sampling schemes (few large versus frequent small sampling boxes), and workstations with varying degrees of sophistication. All estimates were validated against exhaustive counts of the same nerve cross sections to obtain calibrated true numbers of myelinated axons (gold standard). In addition, we quantified errors in particle identification by comparing light microscopic and electron microscopic images of selected consecutive sections. Biological variation was 15.6%. There was no significant difference between the two stereological approaches or workstations used, but sampling schemes with few large samples yielded larger differences (20.7%±3.7% SEM) of estimates from true values, while frequent small samples showed significantly smaller differences (12.7%±1.9% SEM). Particle identification was accurate in 94% of cases (range: 89–98%). The most common identification error was due to profiles of Schwann cell nuclei mimicking profiles of small myelinated nerve fibers. We recommend sampling frequent small rather than few large areas, and conclude that workstations with basic stereological equipment are sufficient to obtain accurate estimates. Electron microscopic verification showed that particle misidentification had a surprisingly variable and large impact of up to 11%, corresponding to 2/3 of the biological variation (15.6%). Thus, errors in particle identification require further attention, and we provide a simple nerve fiber recognition test to assist investigators with self-testing and training

Which governance of university-industry interactions increases the value of industrial inventions?

While evidence suggests that industry inventors’ interactions with universities enhance invention value, the role of interaction governance has so far been overlooked. Relying on an original survey of industry inventors of European patents based in Italy, we show that governance matters. Personal contractual collaborations between firms and individual academics lead to higher-value inventions than collaborations mediated by university institutions. The former enable more effective exploitation of academic knowledge, by facilitating its full transmission and integration into the firm’s knowledge base

International knowledge flows between industry inventors and universities: the role of multinational companies

We investigate the determinants of industry researchers’ interactions with universities in different localities, distinguishing between local and international universities. We analyze the extent to which local and international interactions are enabled by different types of individual personal networks (education, career based), and by their access to different business networks through their employer companies (local vs. domestic or international multinational company networks). We control for selection bias and numerous other individual and firm-level factors identified in the literature as important determinants of interaction with universities. Our findings suggest that industry researchers’ personal networks play a greater role in promoting interactions with local universities (i.e. in the same region, and other regions in the same country) while researcher employment in a multinational is especially important for establishing interaction with universities abroad

Tubulization with chitosan guides for the repair of long gap peripheral nerve injury in the rat

Biosynthetic guides can be an alternative to nerve grafts for reconstructing severely injured peripheral nerves. The aim of this study was to evaluate the regenerative capability of chitosan tubes to bridge critical nerve gaps (15 mm long) in the rat sciatic nerve compared with silicone (SIL) tubes and nerve autografts (AGs). A total of 28 Wistar Hannover rats were randomly distributed into four groups (n = 7 each), in which the nerve was repaired by SIL tube, chitosan guides of low (∼2%, DAI) and medium (∼5%, DAII) degree of acetylation, and AG. Electrophysiological and algesimetry tests were performed serially along 4 months follow-up, and histomorphometric analysis was performed at the end of the study. Both groups with chitosan tubes showed similar degree of functional recovery, and similar number of myelinated nerve fibers at mid tube after 4 months of implantation. The results with chitosan tubes were significantly better compared to SIL tubes (P < 0.01), but lower than with AG (P < 0.01). In contrast to AG, in which all the rats had effective regeneration and target reinnervation, chitosan tubes from DAI and DAII achieved 43 and 57% success, respectively, whereas regeneration failed in all the animals repaired with SIL tubes. This study suggests that chitosan guides are promising conduits to construct artificial nerve grafts