1,294 research outputs found
A study on the statistical convergence of turbulence simulations around a cylinder
The turbulent flow around a circular cylinder at a Reynolds number equal to 3900 is studied by an implicit Large
Eddy Simulation performed by means of a discontinuous Galerkin finite element solver. The average velocity field in the wake
is evaluated and compared with experimental data from the literature. The focus of the present work is on the estimation of the
statistical uncertainty which is related to the use of a finite time window for the averaging operation. This topic represents an
open problem for both Direct Numerical Simulations and Large Eddy Simulations in which it is difficult to define a priori the size
of the time window which gives statistically converged averaged quantities. Different techniques to estimate this uncertainty are
compared in order to get a quantitative criterion for checking the convergence of statistics. In particular, the Non-Overlapping
Batch Means and the Batch Means Batch Correlations techniques are applied to the present test case
La sentence de Yhwh comme chemin de rédemption et deuxième possibilité de conversion. Analyse rhétorique de Gn 3
L’objectif de ces pages est de montrer les résultats de l’analyse rhétorique biblique et sémitique appliquée à la séquence de Gn 3. Ce chapitre comprend cinq passages qui ont été analysés séparément dans des contributions antérieures. Le premier (1-5) présente le dialogue entre le serpent et la femme, le second (6-8) la faute d’Adam et d’Ève. Le troisième expose le rîb (« controverse », « dispute », « procès ») de Dieu envers l’homme et la femme ; Dieu dévoile leur péché, mais ils refusent de..
The patient with rhinitis in the pharmacy. A cross-sectional study in real life
In the practical management of allergic rhinitis (AR), pharmacists are usually the first-line contact, also because some medications are available as over the counter. Therefore, pharmacists may represent an important resource, in mediating the interaction between patients and physicians. We evaluated the clinical/demographic characteristics of patients with respiratory allergies who consulted their pharmacists as first-line contact. A patient-oriented questionnaire was developed by a scientific committee including pharmacists, GPs, allergists, pulmonologists and ENT specialists
Heparins and 2019-nCoV infection: a narrative review
Abstract. – OBJECTIVE: Patients with
2019-nCoV infection have a high risk to develop venous thrombotic events. Several guidelines recommend the use of either unfractionated heparin or low molecular weight heparins in
preventing thrombotic events in these patients.
However, results from clinical studies, so far
published, reached controversial conclusions
on heparin efficacy in this kind of patients since
the incidence of venous thromboembolism remains high despite prophylaxis. This narrative
review aims to provide an overview of the antiviral and anti-inflammatory properties of heparins and their efficacy and safety in SARSCoV-2 medical ward-patients. Moreover, anatomical findings and ongoing trials are also reported. Finally, this narrative review tries to explain why heparins fail to prevent venous thrombosis.
MATERIALS AND METHODS: We searched
for the most relevant published studies on heparins and 2019-nCoV infected patients using the
MEDLINE electronic database in the period between January and December 2020. Articles
were preliminarily defined as eligible if they:
a) were in English language, b) enrolled 250 or
more medical ward-patients and 100 or more
ICU-patients, c) reported results on patients
treated with heparins in a percentage of at least
70% and d) performed an objectively confirmed
diagnosis of VTE.
RESULTS: Data from medium to large scientific studies show that the incidence of venous
thrombotic events in medical ward-patients with
SARS-CoV-2 vary between 0% and 8.3%, while
this rate is higher, from 6.2% to 49%, in Intensive Care Unit-patients. However, heparins reduce the mortality rate in these patients of about
50%. Histological findings show that thrombosis could affect capillaries, main and small-midsized vessels, and it is associated with diffuse
alveolar damage.
CONCLUSIONS: Heparins have anti-inflammatory and anti-viral properties, which may be
of help in reducing mortality in SARS-CoV-2 patients. Failure of heparins at prophylactic dosages in preventing VTE, especially in ICU-patients,
could be due to the severity of the disease. Data
on the use of heparins in an early phase of the
2019-nCoV infection are still lacking
Post-Treatment Edema after Meningioma Radiosurgery is a Predictable Complication
Symptomatic post-treatment edema (PTE) causing seizures, focal deficits, and intracranial hypertension is a rather common complication of meningioma radiosurgery. Factors associated to the occurrence of PTE still needs to be clarified. We retrospectively analyzed our patients' data to identify factors associated with the development of symptomatic PTE. Supposed risk factors were systematically analyzed. Between July 2007 and March 2014, 245 meningiomas in 229 patients were treated by a single fraction or multisession radiosurgery (2-5 fractions) or hypofractionated stereotactic radiotherapy (6-15 fractions) using the CyberKnife system (Accuray Inc., Sunnyvale, CA) at the University Hospital of Messina, Italy. Local tumor control was achieved in 200 of 212 patients with World Health Organization (WHO) Grade I meningiomas (94%) at a mean follow-up of 62 months. Symptomatic PTE on MRI was diagnosed in 19 patients (8.3%) causing seizure (n=17, 89%), aggravating headache (n=12, 63%), or focal deficits (n=13, 68%). Four variables were found to be associated with the likelihood of edema development, including tumor volume > 4.5 mL, non-basal tumor location, tight brain/tumor interface, and atypical histology. Nonetheless, when multivariate logistic regression analysis was performed, only tumor volume and brain-tumor interface turned out to be independent predictors of PTE development. Our results suggest that the factor associated with the risk of developing PTE is associated to characteristics of meningioma rather than to the treatment modality used. Accordingly, an appropriate patient selection is the way to achieve safe treatment and long-term disease control
Application of Recombined Milk to Produce Crescenza-Type Cheese in Laboratory-Scale Cheesemaking: Implications on Technology and Sensory Properties
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