Incidence and Predictors of Adolescent's Early Sexual Debut After three Decades of HIV Interventions in Tanzania: A time to Debut Analysis.

To determine the incidence and predictors of adolescent's early sexual debut after three decades of HIV interventions in Tanzania. In a cross-section study of adolescents aged 16-19 residing in Morogoro Municipality, information on socio-demographic, parental-and-peer communication, and sexual behaviors were collected. Cox-regression analysis was used to examine predictors of time to sexual debut. A total of 316 adolescents with mean age of 17.5±0.9 were recruited. Half (48.7%) of adolescent were sexually active with mean age at sexual debut of 14.6±2.3. Of these, 57.8% had sex before their 15(th) birthday with incidence of early sexual debut of 17.4/1000 person-years at risk. Adolescent family characteristics, peer pressure, alcohol use, parental and peer communication were key predictors of early sexual debut. Parental and peer communication strategies works calling for efforts to increase its scope to reach all adolescents alongside promoting family stability and reducing adolescent alcohol consumption

Properties of galaxy halos in Clusters and Voids

We use the results of a high resolution N-body simulation to investigate the role of the environment on the formation and evolution of galaxy-sized halos. Starting from a set of constrained initial conditions, we have produced a final configuration hosting a double cluster in one octant and a large void extending over two octants of the simulation box. We present results for two statistics: the relationship between 1-D velocity dispersion and mass and the probability distribution of the spin parameter $P(\lambda)$. The \svm relationship is well reproduced by the Truncated Isothermal Sphere (TIS) model introduced by Shapiro et al. (1999), although the slope is different from the original prediction. A series of \svm relationships for different values of the anisotropy parameter $\beta$, obtained using the theoretical predictions by Lokas and Mamon (2001) for NFW density profiles are found to be only marginally consistent with the data. Using some properties of the equilibrium TIS models, we construct subsamples of {\em fiducial} equilibrium TIS halos from each of the three subregions, and we study their properties. For these halos, we do find an environmental dependence of their properties, in particular of the spin parameter distribution $P(\lambda)$. We study in more detail the TIS model, and we find new relationships between the truncation radius and other structural parameters. No gravitationally bound halo is found having a radius larger than the critical value for gravithermal instability for TIS halos (\rt $\ge 34.2 r_{0}$, where $r_{0}$ is the core radius of the TIS solution). We do however find a dependence of this relationship on the environment, like for the $P(\lambda)$ statistics. These facts hint at a possible r\^{o}le of tidal fields at determining the statistical properties of halos.Comment: 12 pages, 14 figures. Accepted by MNRAS. Adopted an improved algorithm for halo finding and added a comparison with NFW model

Food Insecurity is Associated with Food Consumption Patterns and Anthropometric Measures but not Serum Micronutrient Levels in Adults in Rural Tanzania.

The purpose of the present paper is to assess the relationship between food insecurity and food consumption patterns, anthropometric measures and serum micronutrient levels in rural Kilimanjaro, Tanzania. A population-based cross-sectional study was carried out between March and May of 2005. Rural Kilimanjaro, Tanzania. Analysis was restricted to 1014 adults aged 15-44 years with children and complete data. A large majority of the participants (91 %) reported some kind of food insecurity. Food insecurity was significantly associated with age, marital status and occupation. Participants reporting food insecurity were significantly less likely to frequently consume animal products, fruits and vegetables compared with participants categorized as food secure. Women categorized as experiencing individual food insecurity had a larger waist circumference than food-secure women (P = 0.026) while the mean BMI of women appeared to decline if they had a child who was food insecure (P = 0.038). There were no observed differences in serum micronutrient levels by food insecurity status. Food insecurity is highly prevalent and associated with food consumption patterns, waist circumference and BMI of women in rural Tanzania. Further studies should apply self-report measures in assessing food insecurity to larger and more diversified populations

Cryopreservation of hazelnut (Corylus avellana l.) axillary buds from in vitro shoots using the droplet vitrification method

Cryopreservation by droplet vitrification was applied to hazelnut (Corylus avellana L.). axillary buds of the Italian cultivated variety Tonda Gentile Romana, which were collected from in vitro growing shoots, immersed in ice cooled PVS2 or PVS3 for 60 or 90 min, then transferred to a droplet of vitrification solution, placed on a strip of aluminium foil, and plunged into liquid nitrogen (LN). Additionally, the effect on the recovery of the mother plant after cryopreservation was evaluated, following a cold pre-treatment at 4◦C for 3 months. The highest regrowth percentage (56.7%) was obtained after applying PVS3 for 60 min, while the application of PVS2 for the same amount of time reduced regrowth to 41.5%. Increasing the exposure to vitrification solutions to 90 min reduced regrowth to 43.3% when PVS3 was applied, and 35.6% if PVS2 was used. The cold pre-treatment on the mother plant did not significantly improve overall regrowth. The cryopreservation process did not decline the rooting ability of the recovered shoot

Evaluation of Spatiotemporal Patterns of the Spinal Muscle Coordination Output during Walking in the Exoskeleton

Recent advances in the performance and evaluation of walking in exoskeletons use various assessments based on kinematic/kinetic measurements. While such variables provide general characteristics of gait performance, only limited conclusions can be made about the neural control strategies. Moreover, some kinematic or kinetic parameters are a consequence of the control implemented on the exoskeleton. Therefore, standard indicators based on kinematic variables have limitations and need to be complemented by performance measures of muscle coordination and control strategy. Knowledge about what happens at the spinal cord output level might also be critical for rehabilitation since an abnormal spatiotemporal integration of activity in specific spinal segments may result in a risk for abnormalities in gait recovery. Here we present the PEPATO software, which is a benchmarking solution to assess changes in the spinal locomotor output during walking in the exoskeleton with respect to reference data on normal walking. In particular, functional and structural changes at the spinal cord level can be mapped into muscle synergies and spinal maps of motoneuron activity. A user-friendly software interface guides the user through several data processing steps leading to a set of performance indicators as output. We present an example of the usage of this software for evaluating walking in an unloading exoskeleton that allows a person to step in simulated reduced (the Moon's) gravity. By analyzing the EMG activity from lower limb muscles, the algorithms detected several performance indicators demonstrating differential adaptation (shifts in the center of activity, prolonged activation) of specific muscle activation modules and spinal motor pools and increased coactivation of lumbar and sacral segments. The software is integrated at EUROBENCH facilities to benchmark the performance of walking in the exoskeleton from the point of view of changes in the spinal locomotor output

Principais plantas medicinais e fitoterapia na terapêutica de afecções estomacais: uma revisão bibliográfica

Introduction: The use of phytotherapy is increasingly common in Brazil and in the world, but most of the treatment of popular use, including for the gastric system, does not have the correct study to prove its efficacy and risks. Methods: To describe the therapeutic purposes of medicinal plants for stomach disorders and the toxicological activities of some of them. Development: A bibliographic survey of articles and theses was carried out that approached the medicinal plants of greater popular use approved or not by ANVISA. Conclusion: There are several effective therapies, but they should be used with caution and guidance to avoid adverse effects typical of any other medicine. Their use with appropriate recommendations should be encouraged because cause less risk compared to allopathic medicines. In addition, the importance of more in-depth studies on these plants is emphasized since many of them do not have concrete data of their active principles and action in the organism.Introdução: O uso da fitoterapia está cada vez mais comum no Brasil e no mundo, mas grande parte dos tratamentos de uso popular, inclusive para o sistema gástrico, não tem o correto estudo para comprovação de sua eficácia e riscos. Métodos: Descrever os fins terapêuticos das plantas medicinais voltadas a afecções de estômago e as atividades toxicológicas de algumas delas. Desenvolvimento: Foi realizado um levantamento bibliográfico de artigos e teses que abordavam as plantas medicinais de maior uso popular aprovadas ou não pela ANVISA. Conclusão: Existem diversas terapêuticas eficazes, porém devem ser usados com cautela e orientação para evitar efeitos adversos próprios de qualquer outro medicamento. Seu uso com as devidas recomendações deve ser incentivado por terem maior possibilidade de cura e menos riscos em comparação com os medicamentos alopáticos. Além disso ressalta-se a importância de estudos mais aprofundados sobre essas plantas visto que grande parte delas não possuem dados concretos de seus princípios ativos e ação no organismo

Vivax malaria in pregnancy and lactation: a long way to health equity

The Sustainable Development Goals (SDG) call for increased gender equity and reduction in malaria-related mortality and morbidity. Plasmodium vivax infections in pregnancy are associated with maternal anaemia and increased adverse perinatal outcomes. Providing radical cure for women with 8-aminoquinolines (e.g., primaquine) is hindered by gender-specific complexities.; A symptomatic episode of vivax malaria at 18 weeks of gestation in a primigravid woman was associated with maternal anaemia, a recurrent asymptomatic P. vivax episode, severe intra-uterine growth restriction with no other identifiable cause and induction to reduce the risk of stillbirth. At 5 months postpartum a qualitative glucose-6-phosphate dehydrogenase (G6PD) point-of-care test was normal and radical cure with primaquine was prescribed to the mother. A 33% fractional decrease in haematocrit on day 7 of primaquine led to further testing which showed intermediate phenotypic G6PD activity; the G6PD genotype could not be identified. Her infant daughter was well throughout maternal treatment and found to be heterozygous for Mahidol variant.; Adverse effects of vivax malaria in pregnancy, ineligibility of radical cure for pregnant and postpartum women, and difficulties in diagnosing intermediate levels of G6PD activity multiplied morbidity in this woman. Steps towards meeting the SDG include prevention of malaria in pregnancy, reducing unnecessary exclusion of women from radical cure, and accessible quantitative G6PD screening in P. vivax-endemic settings

Valorization of Apple Peels through the Study of the Effects on the Amyloid Aggregation Process of κ-Casein

Waste valorization represents one of the main social challenges when promoting a circular economy and environmental sustainability. Here, we evaluated the effect of the polyphenols extracted from apple peels, normally disposed of as waste, on the amyloid aggregation process of κ-casein from bovine milk, a well-used amyloidogenic model system. The effect of the apple peel extract on protein aggregation was examined using a thioflavin T fluorescence assay, Congo red binding assay, circular dichroism, light scattering, and atomic force microscopy. We found that the phenolic extract from the peel of apples of the cultivar "Fuji", cultivated in Sicily (Caltavuturo, Italy), inhibited κ-casein fibril formation in a dose-dependent way. In particular, we found that the extract significantly reduced the protein aggregation rate and inhibited the secondary structure reorganization that accompanies κ-casein amyloid formation. Protein-aggregated species resulting from the incubation of κ-casein in the presence of polyphenols under amyloid aggregation conditions were reduced in number and different in morphology