Processing model for tungsten powders and extention to nanoscale size range

Nanoscale tungsten powders promise access to very hard, strong and wear resistant materials via the press–sinter route. A small particle size changes the response during sintering, requiring lower temperatures and shorter times to attain dense but small grain size structures. On the other hand, oxide reduction and impurity evaporation favour high sintering temperatures and long hold times. Accordingly, press–sinter processing encounters conflicting constraints when applied to small particles. Presented here is an analysis of press–sinter tungsten particle processing to isolate conditions that balance the temperature and size dependent effects. The calculations are pinned by existing data. Opportunities are identified for new consolidation approaches to deliver a small grain size in a full density structure

Genome-wide profiling of uncapped mRNA

Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs. Profiling uncapped mRNA molecules is important for the understanding of the transcriptome, whose composition is determined by a balance between mRNA synthesis and degradation. In this chapter, we describe a method to profile these uncapped mRNAs at the genome scale

A Dataset and an Approach for Identity Resolution of 38 Million Author IDs extracted from 2B Git Commits

The data collected from open source projects provide means to model large software ecosystems, but often suffer from data quality issues, specifically, multiple author identification strings in code commits might actually be associated with one developer. While many methods have been proposed for addressing this problem, they are either heuristics requiring manual tweaking, or require too much calculation time to do pairwise comparisons for 38M author IDs in, for example, the World of Code collection. In this paper, we propose a method that finds all author IDs belonging to a single developer in this entire dataset, and share the list of all author IDs that were found to have aliases. To do this, we first create blocks of potentially connected author IDs and then use a machine learning model to predict which of these potentially related IDs belong to the same developer. We processed around 38 million author IDs and found around 14.8 million IDs to have an alias, which belong to 5.4 million different developers, with the median number of aliases being 2 per developer. This dataset can be used to create more accurate models of developer behaviour at the entire OSS ecosystem level and can be used to provide a service to rapidly resolve new author IDs

Comparison of voluntary food intake and palatability of commercial weight loss diets in healthy dogs and cats

Background Obesity in dogs and cats is usually managed by dietary energy restriction using a purpose-formulated weight loss diet, but signs of hunger and begging commonly occur causing poor owner compliance. Altering diet characteristics so as to reduce voluntary food intake (VFI) can improve the likelihood of success, although this should not be at the expense of palatability. The aim of the current study was to compare the VFI and palatibility of novel commercially available canine and feline weight loss diets. Methods The relative performance of two canine (C1 and C2) and two feline (F1 and F2) diets was assessed in groups of healthy adult dogs and cats, respectively. Diets varied in energy, protein, fibre, and fat content. To assess canine VFI, 12 (study 1) and 10 (study 2) dogs were offered food in 4 meals, for 15 min on each occasion, with hourly intervals between the meals. For feline VFI, 12 cats were offered food ad libitum for a period of 18 h per day over 5 consecutive days. The palatability studies used separate panels of 37 dogs and 30 cats, with the two diets being served, side-by-side, in identical bowls. Results In dogs, VFI was significantly less for diet C1 than diet C2 when assessed on energy intake (study 1, 42% less, P = 0.032; study 2, 28% less, P = 0.019), but there was no difference in gram weight intake (study 1: P = 0.964; study 2: P = 0.255). In cats, VFI was 17% less for diet F1 than diet F2 when assessed by energy intake (P < 0.001), but there was again no difference in gram weight (P = 0.207). There was no difference in palatability between the two canine diets (P = 0.490), whilst the panel of cats diet preferred F1 to F2 (P < 0.001). Conclusion Foods with different characteristics can decrease VFI without affecting palatability in both dogs and cats. The effects seen could be due to decreased energy content, decreased fat content, increased fibre content, different fibre source, and increased protein content. Further studies are now needed to determine whether similar findings occur in obese dogs and cats on controlled weight loss programmes

Septic shock in pregnancy due to pyogenic sacroiliitis: a case report

This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens