11 research outputs found

    The Gap Analysis Program: A Proactive Approach to Biodiversity Conservation

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    This article introduces Extension professionals to the U.S. Geological Survey\u27s Gap Analysis Program (GAP). GAP seeks to inform the natural resource policy process by providing land cover, stewardship, and species distribution data to decision makers. GAP data may be used to make land use decisions at different geographic levels. GAP aims to address biodiversity conservation in a proactive manner, paying unique attention to the protection of common species and their habitats. Extension professionals may also find GAP data helpful in education and outreach programs designed to inform the public of the role individuals can play in biodiversity maintenance

    Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

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    The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

    The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2

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    The design and performance of the inner detector trigger for the high level trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-18 data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector recorded 35.6 fb1^{-1}, 46.9 fb1^{-1}, and 60.6 fb1^{-1} respectively of proton-proton collision data at a centre-of-mass energy of 13 TeV. In order to deal with the very high interaction multiplicities per bunch crossing expected with the 13 TeV collisions the inner detector trigger was redesigned during the long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of these developments is provided and the performance of the tracking in the trigger for the muon, electron, tau and bb-jet signatures is discussed. The high performance of the inner detector trigger with these extreme interaction multiplicities demonstrates how the inner detector tracking continues to lie at the heart of the trigger performance and is essential in enabling the ATLAS physics programme

    The Conservation Reserve Program: A Tool for Public Participation in Biodiversity Management and Conservation

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    This article introduces Extension professionals to the Conservation Reserve Program (CRP) of the U.S. Department of Agriculture\u27s Farm Service Agency. CRP allows agricultural landowners to receive rental and incentive payments for entering into resource-conserving land cover contracts of between 10 and 15 years in duration. CRP is a mutually beneficial manner in which the agricultural public can contribute to the maintenance and conservation of our nation\u27s biodiversity. Extension professionals may find CRP helpful in improving the quality of crop acreages and pasturelands within a particular jurisdiction and reclaiming agricultural land lost to soil erosion or invasive cover species

    Inflammation and colorectal cancer: colitis-associated neoplasia

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