Laser Cooling of Molecular Anions

We propose a scheme for laser cooling of negatively charged molecules. We briefly summarise the requirements for such laser cooling and we identify a number of potential candidates. A detailed computation study with C$\_2^-$, the most studied molecular anion, is carried out. Simulations of 3D laser cooling in a gas phase show that this molecule could be cooled down to below 1 mK in only a few tens of milliseconds, using standard lasers. Sisyphus cooling, where no photo-detachment process is present, as well as Doppler laser cooling of trapped C$\_2^-$, are also simulated. This cooling scheme has an impact on the study of cold molecules, molecular anions, charged particle sources and antimatter physics

Association of Exercise with Inhibitory Control and Prefrontal Brain Activity Under Acute Psychosocial Stress

Psychosocial stress has negative effects on cognition in adolescents. The aim of this study was to investigate whether physical exercise can buffer such effects on inhibitory control and associated cortical brain areas. Forty-two male high school students aged 16-20 years and with either low or high exercise levels performed a Stroop task under stress-free conditions and after the Trier Social Stress Test (TSST). Oxygenation of the dorsolateral prefrontal cortex (DLPFC) was measured with functional near-infrared spectroscopy. For inhibitory control, there was no significant primary effect of condition (; F; (1,40) = 1.09,; p; = 303.,; ηp²; = 0.027) and no significant condition × group interaction (; F; (1,40) = 2.40,; p; = 0.129,; ηp²; = 0.057). For DLPFC oxygenation, a significant primary effect of condition was observed (; F; (1,38) = 6.10,; p; = 0.018,; ηp²; = 0.138). However, the condition × group interaction (; F; (1,38) = 0.05,; p; = 0.823,; ηp²; = 0.001) remained not significant. Adolescents' exercise level was not associated with inhibitory control before and after stress. An impact of stress on a neurocognitive level was observed

The Influence of an Acute Exercise Bout on Adolescents' Stress Reactivity, Interference Control, and Brain Oxygenation Under Stress

Background:High psychosocial stress can impair executive function in adolescents,whereas acute exercise has been reported to benefit this cognitive domain. The aim ofthis study was to investigate whether an acute bout of aerobic exercise improves theinhibitory aspect of executive function and the associated dorsolateral prefrontal cortex(DLPFC) oxygenation when under stress.Methods:Sixty male high school students aged 16–20 years performed a Strooptask (baseline condition) and were randomly assigned to an exercise group (30 min onergometer at 70% of maximum heart rate) and a control group (30 min of reading).Subsequently, all participants underwent a modified Trier Social Stress Test, whichincluded a Stroop task under enhanced stress. The Stroop tasks in both conditionswere combined with functional near-infrared spectroscopy to record changes in DLPFCoxygenation in response to the tasks. Stress reactivity was measured with salivasamples (cortisol, alpha-amylase), heart rate monitoring, and anxiety scores.Results:All stress parameters indicated increases in response to the stressor(p<0.001), with higher alpha-amylase [t(58) =−3.45,p= 0.001,d= 1.93] andanxiety [t(58) =−2.04,p= 0.046,d= 0.53] reactions in the control compared to theexercise group. Controlling for these two parameters, repeated measures analyses ofcovariance targeting changes in Stroop interference scores showed no main effect ofstress [F(1,58) = 3.80,p= 0.056,ηp2= 0.063] and no stress×group interaction[F(1,58) = 0.43,p= 0.517,ηp2= 0.008]. Similarly, there was no main effect ofstress [F(1,58) = 2.38,p= 0.128,ηp2= 0.040] and no stress×group interaction[F(1,58) = 2.80,p= 0.100,ηp2= 0.047] for DLPFC oxygenation.Conclusion:Our study confirms potentially health-enhancing effects of acute exerciseon some of the physiological and psychological stress reactivity indicators. However,our data do not support the notion of an effect on interference control and DLPFCactivation under stress

Psychometric Properties and Convergent Validity of the Shirom-Melamed Burnout Measure in Two German-Speaking Samples of Adult Workers and Police Officers

Burnout is considered an occupation-related psychological syndrome consisting of emotional, physical, and cognitive exhaustion. To assess dimensions of burnout, the Shirom-Melamed Burnout Measure (SMB; M; ) is widely used, but its validity and reliability have rarely been examined in adult samples. The aim of this study is to examine the psychometric properties of the German version of the SMB; M; in two independent samples of adults. In total, 311 adult workers and 201 police officers completed the SMB; M; , and questionnaires related to perceived stress and mental well-being. Descriptive statistics, internal consistency, convergent validity, and factorial validity were assessed for both samples, separately for male and female participants. The German SMB; M; had adequate psychometric properties and sufficient convergent validity. In confirmatory factor analyses, we found a good fit for both the first- and second-order model. Furthermore, measurement invariance across gender was observed in both samples. Although the SMB; M; is a popular instrument among burnout researchers, this study demonstrates for the first time that the SMB; M; can be considered a valid and reliable tool to assess burnout symptoms in both male and female adults and across different professional groups. Furthermore, with its 14 items, the SMB; M; is a succinct and economic self-assessment tool for symptoms of burnout

Frequency Doubling Nanocrystals for Cancer Theranostics

A novel bio-photonics approach based on the nonlinear optical process of second harmonic generation by non-centrosymmetric nanoparticles is presented and demonstrated on malignant human cell lines. The proposed method allows to directly interact with DNA in absence of photosensitizing molecules, to enable independent imaging and therapeutic modalities switching between the two modes of operation by simply tuning the excitation laser wavelength, and to avoid any risk of spontaneous activation by any natural or artificial light source.Comment: 16 pages, 7 figure

Does Cardiorespiratory Fitness Moderate the Association between Occupational Stress, Cardiovascular Risk, and Mental Health in Police Officers?

Background:; Chronic exposure to occupational stress may lead to negative health consequences. Creating less stressful work environments and making employees physically and psychologically more resilient against stress are therefore two major public health concerns. This study examined whether cardiorespiratory fitness moderated the association between occupational stress, cardiovascular risk, and mental health.; Methods:; Stress was assessed via the Effort-Reward Imbalance and Job Demand-Control models in 201 police officers (36% women, Mage = 38.6 years). Higher levels of blood pressure, blood lipids, blood sugar, and unfavorable body composition were considered as cardiovascular risk factors. Burnout, insomnia and overall psychological distress were used as mental health indicators. Cardiorespiratory fitness was assessed with a submaximal bicycle test.; Results:; High cardiorespiratory fitness levels were associated with a reduced cardiometabolic risk, whereas high stress levels were associated with better mental health. Among participants who perceived a high Effort-Reward Imbalance, those with high fitness levels showed lower overall cardiovascular risk scores than their colleagues with low fitness levels.; Conclusions:; Work health programs for police officers should consider the early screening of burnout, sleep disturbances, and overall mental wellbeing. To increase cardiovascular health, including fitness tests in routine health checks and promoting physical activity to further increase cardiorespiratory fitness appears worthwhile

Aerosol exposure of staff during dental treatments: a model study

Background: Due to exposure to potentially infectious aerosols during treatments, the dental personnel is considered being at high risk for aerosol transmitted diseases like COVID-19. The aim of this study was to evaluate aerosol exposure during different dental treatments as well as the efficacy of dental suction to reduce aerosol spreading. Methods: Dental powder-jet (PJ; Air-Flow (R)), a water-cooled dental handpiece with a diamond bur (HP) and water-cooled ultrasonic scaling (US) were used in a simulation head, mounted on a dental unit in various treatment settings. The influence of the use of a small saliva ejector (SE) and high-volume suction (HVS) was evaluated. As a proxy of aerosols, air-born particles (PM10) were detected using a Laser Spectrometer in 30 cm distance from the mouth. As control, background particle counts (BC) were measured before and after experiments. Results: With only SE, integrated aerosol levels [median (Q25/Q75) mu g/m(3) s] for PJ [91,246 (58,213/118,386) mu g/m(3) s, p 0.05] and US [6558 (6002/7066) mu g/m(3) s; p > 0.05] did not increase aerosol levels significantly. The use of HVS significantly decreased aerosol exposure for PJ [37,170 (29,634/51,719) mu g/m(3) s; p < 0.01] and HP [5476 (5066/5638) mu g/m(3) s; p < 0.001] compared to SE only, even reaching lower particle counts than BC levels for HP usage (p < 0.001). Conclusions: To reduce the exposure to potentially infectious aerosols, HVS should be used during aerosol-forming dental treatments

Does Cardiorespiratory Fitness Buffer Stress Reactivity and Stress Recovery in Police Officers? A Real-Life Study

High levels of cardiorespiratory fitness have the potential to buffer against physical and mental health impairments, which can result from exposure to occupational stress. Police officers are especially at risk of high psychosocial stress; therefore, effective intervention strategies are warranted. Given this background, the purpose of the present study was to examine whether police officers with different levels of cardiorespiratory fitness differ with regard to their (a) physiological stress reactivity during acute real life stress situations, and (b) physiological recovery related to acute and chronic work stress. In total, 201 police officers took part in this study (M = 38.6 years, SD = 10.1, 35.8% females). Officers were contacted eight times on a smartphone during their workday, and asked to report their current level of positive and negative affect, as well as feelings of stress and anger. Physiological stress responses and recovery (heart rate variability) were assessed using Movisens EcgMove3 devices. The Åstrand bicycle ergometer test was used to assess participants' cardiorespiratory fitness. Chronic work stress was assessed using the effortreward imbalance model and the job strain model. Multilevel modeling was used to test buffering effects of cardiorespiratory fitness on physiological stress reactivity. Linear regression was applied to test stress-buffering effects of cardiorespiratory fitness on physiological recovery. Results showed lowered physiological stress reactivity to acute work stress in officers with higher levels of cardiorespiratory fitness. However, these results were not consistent, with no effects occurring for feelings of anger, positive affect, and negative affect. Chronic work stress (effort-reward imbalance) was related to lower physiological recovery. Cardiorespiratory fitness was positively related to physiological recovery. Data did not support interactions between work stress and cardiorespiratory fitness on physiological recovery. To some extent, cardiorespiratory fitness seems to have the potential to buffer stress reactivity in police officers in acute stress situations. Therefore, we encourage promoting fitness programs which aim to enhance cardiorespiratory fitness in stressful occupations such as law enforcement.+repphzhbib2020