1,573 research outputs found
Preliminary study on the use of near infrared hyperspectral imaging for quantitation and localisation of total glucosinolates in freeze-dried broccoli
peer-reviewedThe use of hyperspectral imaging to (a) quantify and (b) localise total glucosinolates in florets of a single broccoli species has been examined. Two different spectral regions (vis–NIR and NIR), a number of spectral pre-treatments and different mask development strategies were studied to develop the quantitative models. These models were then applied to freeze-dried slices of broccoli to identify regions within individual florets which were rich in glucosinolates. The procedure demonstrates potential for the quantitative screening and localisation of total glucosinolates in broccoli using the 950–1650 nm wavelength range. These compounds were mainly located in the external part of florets.Universidad de SevillaJ.M. Hernández-Hierro thanks the Spanish MICINN for the Juan de la Cierva contract (JCI-2011-09201) and Universidad de Sevilla for the mobility Grant (Universidad de Sevilla Research Plan). Spanish MICINN Project AGL2011-30254-C02 and Junta de Andalucia PGC Project AGR 6331
Chemokine receptors coordinately regulate macrophage dynamics and mammary gland development
Macrophages are key regulators of developmental processes, including those involved in mammary gland development. We previously demonstrated that the atypical chemokine receptor, ACKR2, contributes to control of ductal epithelial branching in the developing mammary gland by regulating macrophage dynamics. ACKR2 is a chemokine-scavenging receptor, which mediates its effects through collaboration with inflammatory chemokine receptors (iCCRs). Here we reveal reciprocal regulation of branching morphogenesis in the mammary gland, whereby stromal ACKR2 modulates levels of the shared ligand CCL7 to control the movement of a key population of CCR1-expressing macrophages to the ductal epithelium. In addition, estrogen, which is essential for ductal elongation during puberty, upregulates CCR1 expression on macrophages. The age at which girls develop breasts is decreasing, which raises the risk of diseases including breast cancer. This study presents a previously unknown mechanism controlling the rate of mammary gland development during puberty and highlights potential therapeutic targets
Intrinsic Absorption in the Spectrum of NGC 7469: Simultaneous Chandra, FUSE, and STIS Observations
We present simultaneous X-ray, far-ultraviolet, and near-ultraviolet spectra
of the Seyfert 1 galaxy NGC 7469 obtained with the Chandra X-Ray Observatory,
the Far Ultraviolet Spectroscopic Explorer, and the Space Telescope Imaging
Spectrograph on the Hubble Space Telescope. Previous non-simultaneous
observations of this galaxy found two distinct UV absorption components, at
-560 and -1900 km/s, with the former as the likely counterpart of the X-ray
absorber. We confirm these two absorption components in our new UV
observations, in which we detect prominent O VI, Ly alpha, N V, and C IV
absorption. In our Chandra spectrum we detect O VIII emission, but no
significant O VIII or O VII absorption. We also detect a prominent Fe K alpha
emission line in the Chandra spectrum, as well as absorption due to
hydrogen-like and helium-like neon, magnesium, and silicon at velocities
consistent with the -560 km/s UV absorber. The FUSE and STIS data reveal that
the H I and C IV column densities in this UV- and X-ray- absorbing component
have increased over time, as the UV continuum flux decreased. We use measured H
I, N V, C IV, and O VI column densities to model the photoionization state of
both absorbers self-consistently. We confirm the general physical picture of
the outflow in which the low velocity component is a highly ionized, high
density absorber with a total column density of 10^20 cm^-2, located near the
broad emission line region, although due to measurable columns of N V and C IV,
we assign it a somewhat smaller ionization parameter than found previously,
U~1. The high velocity UV component is of lower density, log N=18.6, and likely
resides farther from the central engine as we find its ionization parameter to
be U=0.08.Comment: Minor correction to abstract; STScI eprint #1683; 50 pages, incl. 19
figures, 4 tables; Accepted to Ap
Effect of Air Injection on Nucleation Rates: An Approach from Induction Time Statistics
From
disruption of the supersaturated solution to improved mass
transfer in the crystallizing suspension, the introduction of a moving
gas phase in a crystallizer could lead to improved rates of nucleation
and crystal growth. In this work, saturated air has been injected
to batch crystallizers to study the effects on formation of the first
crystal and subsequent turbidity buildup. To account for the typically
large sample-to-sample variation, nucleation rates were evaluated
for a large number of replicates using probability distributions of
induction times. The slope and the intercept of the distributions
were studied independently, allowing the simultaneous determination
of the mean induction time and a certain detection delay related to
the rate of crystal growth after formation of the first nucleus. When
saturated air was injected in aqueous glycine solutions, the average
detection delay was reduced from 69 to 13 min, and the mean induction
time decreased from 128 to 36 min. The effect on aqueous solutions
of l-arginine was less apparent, with a detection delay reduction
from 15 to 3 min, and no significant changes on the rate of primary
nucleation. These results demonstrate the potential of this technique
for reduction in nucleation induction time and improved mass deposition
rates in crystallization operations
Model-Independent Comparison of Direct vs. Indirect Detection of Supersymmetric Dark Matter
We compare the rate for elastic scattering of neutralinos from various nuclei
with the flux of upward muons induced by energetic neutrinos from neutralino
annihilation in the Sun and Earth. We consider both scalar and axial-vector
interactions of neutralinos with nuclei. We find that the event rate in a kg of
germanium is roughly equivalent to that in a - to -m muon
detector for a neutralino with primarily scalar coupling to nuclei. For an
axially coupled neutralino, the event rate in a 50-gram hydrogen detector is
roughly the same as that in a 10- to 500-m muon detector. Expected
experimental backgrounds favor forthcoming elastic-scattering detectors for
scalar couplings while the neutrino detectors have the advantage for
axial-vector couplings.Comment: 10 pages, self-unpacking uuencoded PostScript fil
Signal averaging x‐ray streak camera with picosecond jitter
We have developed an averaging picosecond x‐ray streak camera using a dc‐biased photoconductive switch as a generator of a high‐voltage ramp. The streak camera is operated at a sweep speed of up to 8 ps/mm, shot‐to‐shot jitter is less than ±1 ps. The streak camera has been used to measure the time history of broadband x‐ray emission from an ultrashort pulse laser‐produced plasma. Accumulation of the streaked x‐ray signals significantly improved the signal‐to‐noise ratio of the data obtained. © 1996 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69581/2/RSINAK-67-3-697-1.pd
Complementary Patents and Market Structure
Many high technology goods are based on standards that require several essential patents owned by different IP holders. This gives rise to a complements and a double mark-up problem. We compare the welfare effects of two different business strategies dealing with these problems. Vertical integration of an IP holder and a downstream producer solves the double mark-up problem between these firms. Nevertheless, it may raise royalty rates and reduce output as compared to non-integration. Horizontal integration of IP holders solves the complements problem but not the double mark-up problem. Vertical integration discourages entry and reduces innovation incentives, while horizontal integration always benefits from entry and innovatio
Quasars and the Big Blue Bump
We investigate the ultraviolet-to-optical spectral energy distributions
(SEDs) of 17 active galactic nuclei (AGNs) using quasi-simultaneous
spectrophotometry spanning 900-9000 Angstrom (rest frame). We employ data from
the Far Ultraviolet Spectroscopic Explorer (FUSE), the Hubble Space Telescope
(HST), and the 2.1-meter telescope at Kitt Peak National Observatory (KPNO).
Taking advantage of the short-wavelength coverage, we are able to study the
so-called "big blue bump," the region where the energy output peaks, in detail.
Most objects exhibit a spectral break around 1100 Angstrom. Although this
result is formally associated with large uncertainty for some objects, there is
strong evidence in the data that the far-ultraviolet spectral region is below
the extrapolation of the near-ultraviolet-optical slope, indicating a spectral
break around 1100 Angstrom. We compare the behavior of our sample to those of
non-LTE thin-disk models covering a range in black-hole mass, Eddington ratio,
disk inclination, and other parameters. The distribution of ultraviolet-optical
spectral indices redward of the break, and far-ultraviolet indices shortward of
the break, are in rough agreement with the models. However, we do not see a
correlation between the far-ultraviolet spectral index and the black hole mass,
as seen in some accretion disk models. We argue that the observed spectral
break is intrinsic to AGNs, although intrinsic reddening as well as
Comptonization can strongly affect the far-ultraviolet spectral index. We make
our data available online in digital format.Comment: 32 pages (10pt), 12 figures. Accepted for publication in Ap
Impairments of auditory scene analysis in Alzheimer's disease
Parsing of sound sources in the auditory environment or ‘auditory scene analysis’ is a computationally demanding cognitive operation that is likely to be vulnerable to the neurodegenerative process in Alzheimer’s disease. However, little information is available concerning auditory scene analysis in Alzheimer's disease. Here we undertook a detailed neuropsychological and neuroanatomical characterization of auditory scene analysis in a cohort of 21 patients with clinically typical Alzheimer's disease versus age-matched healthy control subjects. We designed a novel auditory dual stream paradigm based on synthetic sound sequences to assess two key generic operations in auditory scene analysis (object segregation and grouping) in relation to simpler auditory perceptual, task and general neuropsychological factors. In order to assess neuroanatomical associations of performance on auditory scene analysis tasks, structural brain magnetic resonance imaging data from the patient cohort were analysed using voxel-based morphometry. Compared with healthy controls, patients with Alzheimer's disease had impairments of auditory scene analysis, and segregation and grouping operations were comparably affected. Auditory scene analysis impairments in Alzheimer's disease were not wholly attributable to simple auditory perceptual or task factors; however, the between-group difference relative to healthy controls was attenuated after accounting for non-verbal (visuospatial) working memory capacity. These findings demonstrate that clinically typical Alzheimer's disease is associated with a generic deficit of auditory scene analysis. Neuroanatomical associations of auditory scene analysis performance were identified in posterior cortical areas including the posterior superior temporal lobes and posterior cingulate. This work suggests a basis for understanding a class of clinical symptoms in Alzheimer's disease and for delineating cognitive mechanisms that mediate auditory scene analysis both in health and in neurodegenerative disease
He II Ly{\beta} Gunn-Peterson Absorption: New HST Observations, and Theoretical Expectations
Observations of He II Ly{\alpha} Gunn-Peterson troughs have proved to be a
valuable probe of the epoch of helium reionization at z~3. Since this optical
depth can become unmeasurably large even for modest He II fractions, various
alternate techniques have been proposed to push to higher redshift, and among
the more promising is looking at higher order Lyman-series troughs. We here
report four new observations of the He II Ly{\beta} trough, including new data
on the only sightline with a prior Ly{\beta} observation. However, the
effective optical depth ratio {\tau}_eff,{\beta}/{\tau}_eff,{\alpha} is not
simply predicted by (f_{\beta} {\lambda}_{\beta})/(f_{\alpha}
{\lambda}_{\alpha})=0.16, and we analyze cosmological simulations to find that
the correct ratio for helium at z~3 is ~0.35. In one case we infer
{\tau}_eff,{\alpha} > 8.8, strong evidence that helium was not fully reionized
at z=3.2--3.5, in agreement with previous measurements suggesting a later
completion of reionization.Comment: ApJ accepted. 25 pages, 3 figures, 4 table
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