Sensores baseados em nanotubos de carbono funcionalizados por ligação não-covalente

A pesquisa na área dos nanomateriais de carbono, como os nanotubos de carbono (CNTs), tem crescido muito rapidamente devido às suas propriedades térmicas, eletrónicas e mecânicas. Muitos esforços têm sido realizados para aumentar a solubilidade destes materiais em diversos solventes e obter dispersões estáveis. Uma das estratégias para dispersar os CNTs consiste na funcionalização química, que apresenta como desvantagem a destruição da estrutura sp2 do carbono destes materiais. Neste últimos anos surgiram vários estudos baseados na funcionalização não-covalente com o intuito de manter as suas propriedades estruturais. Com este fim, tem sido utilizadas estruturas poliaromáticas substituídas como perilenos e pirenos que podem estabelecer interações do tipo π-π com a superfície aromática dos CNTs ou do grafeno. Neste trabalho pretende-se apresentar uma revisão bibliográfica da utilização da funcionalização nãocovalente no desenvolvimento de sensores e biossensores eletroquímicos em substrato de materiais nanoestruturados de carbono (MWCNTs, SWCNTs, grafeno)

Conjugations on the Hardy space H2H^{2}

A conjugation $C$ on a separable complex Hilbert space $\mathcal H$ is an antilinear operator that is isometric and involutive. In this notes, we characterize all conjugations on the Hardy-Hilbert space $H^{2}$ over the disk. In addition, we characterize complex symmetric Toeplitz operators with a special type of these conjugations.Comment:

Tumores abdominais raros com crescimento intracardíaco. A propósito de dois casos operados com sucesso

Abdominal tumors that can grow through vascular lumen and spread to the right heart are rare. Although these tumors have different histologic aspects, they may cause similar abdominal and cardiac symptoms and are a serious risk factor for pulmonary embolism and sudden death when they reach the right atrium and tricuspid valve. The best treatment is radical surgical resection of the entire tumor using cardiopulmonary bypass with or without deep hypothermia and total circulatory arrest. We report the cases of two patients, the first with leiomyosarcoma of the inferior vena cava and the other with intravenous leiomyomatosis of the uterus that showed intravascular growth up to right atrium and ventricle, who underwent successful radical resection in a one-stage procedure with the use of cardiopulmonary bypass. We discuss the clinical and histologic aspects and imaging diagnosis and review the literature.Tumores abdominais que crescem pela luz dos vasos e atingem o coração são raros. Estes tumores possuem características histológicas distintas porém causam sintomas abdominais e cardíacos semelhantes e apresentam elevado risco de embolia pulmonar e morte súbita quando atingem o átrio direito e a valva tricúspide. O tratamento mais eficaz é a ressecção cirúrgica radical de todo o tumor usando-se circulação extracorpórea com ou sem hipotermia profunda e parada circulatória total. Relatamos os casos de dois pacientes, o primeiro portador de leiomiossarcoma primário da veia cava inferior e o segundo com leiomiomatose intravascular uterina com crescimento pela veia cava inferior alcançando o átrio e ventrículo direitos, que foram operados com sucesso para ressecção concomitante do tumor primário e de sua extensão intra-cardíaca, com auxílio da circulação extracorpórea. Os aspectos clínicos, laboratoriais e histopatológicos são discutidos e é feita revisão da literatura

Lentil-based snack: development and nutritious properties

Legume grains provide not only a unique nutrient profile essential for good human health, such as protein, fiber, carbohydrates, fatty acids, minerals, vitamins, and phenolic compounds, but they also provide excellent environmental benefits. Besides, they adapt to contemporary food patterns, like flexitarian, vegetarian, vegan, and gluten-free. However, legume consumption continues to be less than desired, opening new opportunities for different intake alternatives. Furthermore, due to agriculture growth and unbalanced animal consumption the food industry aims to increase and diversify alternative protein formulations. Amongst the legumes, lentils have a fast-cooking time, high arginine, antioxidant flavonoids, and a low glycemic index which helps avoid peaks in blood glucose, improving metabolic control, and recent epidemiological studies suggest that they may help combat cardiovascular disease and diabetes mellitus, both with high prevalence worldwide. Based on this knowledge, we developed a muffin in which commercial oatmeal was partially substituted with lentil flour. The nutritional value of the snack was evaluated, and it was also performed microbiological analyses. The lentil-based muffin had higher protein and fiber and lower carbohydrate content compared to the oatmeal-based muffin. The aim of these muffins is that they are suitable for all consumers, including diabetics. This project seeks to be a central element in the promotion of one of the oldest grain legumes, contributing to an increase in its consumption and consequent commercial valorization.info:eu-repo/semantics/publishedVersio

Labrys portucalensis F11 efficiently degrades Di-(2-ethylhexyl) Phthalate

info:eu-repo/semantics/publishedVersio

Investigation of human papillomavirus by hybrid capture II in cervical carcinomas including 113 adenocarcinomas and related lesions

Hybrid capture is an easy and highly sensitive technique for screening population due to its capacity to detect malignant and premalignant lesions of the cervix. To evaluate its ensitivity, we investigated the frequency of high-risk human papillomavirus (HPV) infection and its correlation with glandular malignant lesions, analyzing a total of 113 cases of adenocarcinomas and related lesions. High-risk HPV was investigated using a hybrid capture II (HC2) assay. Samples were collected in two different ways: either brushed directly from surgical specimens before fixation or collected from the patients. We also investigated the frequency of HPV in squamous malignant lesions, 65 squamous cell carcinomas (SCC) and 66 in situ squamous cell carcinomas (ISSCC), to compare the occurrence of HPV for these lesions. The 113 glandular lesions comprised 62 invasive adenocarcinomas (IAC), 8 in situ adenocarcinomas (ISAC), 26 IAC plus SCC, and 17 adenosquamous cells carcinomas (ASCC). The HPV-positive reactions were as follows: 51 (82.2%) in IAC, 8 (100%) in ISAC, 25 (96.1%) in IAC plus SCC, and 14 (82.3%) in ASCC. HC2-positive results in the squamous malignant lesions were as follows: 58 of 63 (89.0%) for SCC and 94 of 103 (91.2%) for ISSCC. High-risk HPV infection was quite similar for glandular and pure squamous invasive malignant lesions, 82.2% and 89.0%, respectively, indicating that high-risk HPV is also highly prevalent in glandular lesions. Although hybrid capture proved to be an excellent adjunctive technique, we do not believe its results merit replacing the Pap smear as a screening tool

Voxel-based investigations of regional cerebral blood flow abnormalities in Alzheimer's disease using a single-detector SPECT system

PURPOSE: To evaluate the feasibility of using the Statistical Parametric Mapping (SPM) program for an automated, voxel-by-voxel assessment of regional cerebral blood flow (rCBF) deficits in Alzheimer's disease (AD) subjects relative to age-matched controls studied with a conventional, single-detector SPECT system. METHODS: We used a databank of 99mTc-HMPAO images of 19 patients with a diagnosis of probable AD and 15 elderly healthy volunteers; data were acquired using an Orbiter-Siemens single-detector SPECT system. Using SPM, images were transformed spatially, smoothed (12mm), and the data were compared on a voxel-by-voxel basis with t-tests. RESULTS: There were significant rCBF reductions in AD patients relative to controls involving regions predicted a priori to be affected in AD, namely the left temporal and parietal neocortices, and the right posterior cingulate gyrus (pOBJETIVO: Avaliar a viabilidade de emprego do programa Statistical Parametric Mapping (SPM) para investigar de forma automatizada, voxel-a-voxel, a presença de déficits de fluxo sanguíneo cerebral regional (FSCr) em pacientes com doença de Alzheimer (DA) comparados a sujeitos-controle pareados para idade, usando imagens de SPECT adquiridas com um equipamento convencional de detector único. MÉTODOS: Foi utilizado um banco de imagens adquiridas após injeção de 99mTc-HMPAO em 19 pacientes com diagnóstico provável de DA e 15 voluntários idosos saudáveis, usando um equipamento de SPECT Orbiter-Siemens de detector único. Empregando o programa SPM, as imagens foram transformadas espacialmente, suavizadas (12mm FWHM), e comparadas estatisticamente voxel-a-voxel entre os dois grupos, usando o teste de T. RESULTADOS: Foram identificadas reduções significativas de FSCr nos pacientes com DA comparados aos controles em regiões previstas a priori como afetadas por esta forma de demência, quais sejam os neocórtices temporal e parietal em hemisfério esquerdo e o cíngulo posterior direito (

Antioxidant, allelopathic and toxic activity of Ochna serrulata

Ochna serrulata (Ochnaceae) is an ornamental plant introduced into Brazil from Asia and Africa. Species of the Ochna genus are rich in phenolic compounds, mainly flavonoids. The biological screening of extracts and fractions showed that this plant exhibited a significant antioxidant activity, when evaluated by the DPPH and reducing potential assays. Ochna serrulata also demonstrated slight toxic activity against Artemia salina and a potential inhibitory allelopathic activity, when evaluated using the Lactuca sativa seed germination test. The ethyl acetate fraction, the most active one, was partitioned on a silica gel column to obtain epicatechin, which showed potential antioxidant activity.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Sistema de consulta e visualização das projeções dos modelos climáticos globais do IPPC AR4 para o Brasil.

Resumo: O objetivo deste trabalho foi desenvolver um sistema de consulta e visualização das projeções para as variáveis climáticas dos modelos do IPCC AR4 para o Brasil, contribuindo para o aumento de informações referentes às mudanças climáticas. O software foi desenvolvido em linguagem C# (Sharp) da Microsoft e os dados foram armazenados em um banco de dados relacional, utilizando o Firebird como sistema gerenciador de banco de dados e a ferramenta IBExpert para interação com o banco. O usuário pode escolher diferentes projeções para as médias mensais de temperatura média, temperatura mínima, temperatura máxima, precipitação, umidade relativa e duração de período de molhamento foliar para os períodos de referência (1961-1990) e do futuro (2011-2040, 2041-2070, 2071-2100) que possui os cenários A2 e B1. O sistema permite aos usuários buscar por parâmetros dos modelos climáticos globais, variáveis climáticas, período e mês. Os resultados são mostrados na forma de grade com a opção de exportar estes dados em arquivo texto (txt). Este sistema permite buscar os dados do IPCC AR4, de maneira simples e consistente com várias opções. Abstract: The aim of this study was to develop a system for searching and data visualization of the projections for the climate variables of the models from the IPCC AR4 for Brazil, contributing to the increase of information about the climate change. The software was developed in C# (Sharp) language from Microsoft and the data were stored in a relational database, using Firebird as the database management system and the IBExpert tool for interaction with the database. The user can choose different projections for the monthly average of mean temperature, minimum temperature, maximum temperature, precipitation, relative humidity, and leaf wetness duration for the reference period (1961-1990) and the future periods (2011-2040, 2041-2070, 2071-2100), A2 and B1 scenarios. The system permits the users to search for parameters of the global climate models, climatic variables, period, and month. The results are showed in a grid structure with the option of exporting this data in a txt (text) file. This system allows searching for the IPCC AR4 data, in a consistent and simple way, with a lot of options