4 research outputs found
Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies
Examples of organometallic compounds as nucleoside analogues are rare within the field of medicinal bioorganometallic chemistry. We report on the synthesis and properties of two chiral ferrocene derivatives containing a nucleobase and a hydroxyalkyl group. These so-called ferronucleosides show promising anticancer activity, with cytostatic studies on five different cancer cell lines indicating that both functional groups are required for optimal activity.status: publishe
Organometallic Nucleoside Analogues with Ferrocenyl Linker Groups: Synthesis and Cancer Cell Line Studies
Examples
of organometallic compounds as nucleoside analogues are
rare within the field of medicinal bioorganometallic chemistry. We
report on the synthesis and properties of two chiral ferrocene derivatives
containing a nucleobase and a hydroxyalkyl group. These so-called
ferronucleosides show promising anticancer activity, with cytostatic
studies on five different cancer cell lines indicating that both functional
groups are required for optimal activity