Organometallic Nucleoside Analogues with Ferrocenyl
Linker Groups: Synthesis and Cancer Cell Line Studies
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Abstract
Examples
of organometallic compounds as nucleoside analogues are
rare within the field of medicinal bioorganometallic chemistry. We
report on the synthesis and properties of two chiral ferrocene derivatives
containing a nucleobase and a hydroxyalkyl group. These so-called
ferronucleosides show promising anticancer activity, with cytostatic
studies on five different cancer cell lines indicating that both functional
groups are required for optimal activity