9 research outputs found
The Lantern Vol. 6, No. 3, June 1938
• Editorial • A Senior Muses • Affinity • From Darkness Into Light • Just an Old Bell! • Memories of a Friend • To a Small Animal as it Passes • The Sky and I • Between the Mountain and the River • Solace • Three Little Islands Far From Home • Beachcomberhttps://digitalcommons.ursinus.edu/lantern/1011/thumbnail.jp
The Lantern Vol. 6, No. 2, March 1938
• Among Our Contributors • Of Special Interest To You! • Jenny Lee • The Arguments Against Isolation • The Note • Visit of the Grandchildren • One Finds God • To The North Lies New Hampshire • The Two Camps in Washington • Substitutes • At Times It Seems So Very Strange • Episode on a Lake Shore • My Campus Song • Irony • A Chinese Mysteryhttps://digitalcommons.ursinus.edu/lantern/1017/thumbnail.jp
The Lantern Vol. 8, No. 3, May 1940
• Sonnet for These Days • Peace Be With You • Creative Citizenship • Tony Solves an Ichthyological Problem • Tippy Tin • A Surgeon Paints • Thoughts • Standing at Ease • Nature\u27s Mistake • Tomorrow • This is Enough • I Built a Shrine to Love • Integer • I Look for Herhttps://digitalcommons.ursinus.edu/lantern/1021/thumbnail.jp
The Lantern Vol. 7, No. 2, March 1939
• Editorial • Easter Eggs • Fever • Sonnets to the Planet We Call Earth • Asking Her Father • New Hampshire Ghost Story • Mary • On Approaching Death • On Turning Over a New Leaf • In Defense of Americanism • What is this Love? • Martyrs of Progress • Recurring • Splintershttps://digitalcommons.ursinus.edu/lantern/1013/thumbnail.jp
The Lantern Vol. 7, No. 2, March 1939
• Editorial • Easter Eggs • Fever • Sonnets to the Planet We Call Earth • Asking Her Father • New Hampshire Ghost Story • Mary • On Approaching Death • On Turning Over a New Leaf • In Defense of Americanism • What is this Love? • Martyrs of Progress • Recurring • Splintershttps://digitalcommons.ursinus.edu/lantern/1013/thumbnail.jp
Development of Endothelium-Denuded Human Umbilical Veins as Living Scaffolds for Tissue-Engineered Small Caliber Vascular Grafts
Tissue Engineering of Small Caliber Vessel Grafts from Human Umbilical Veins
Human umbilical veins (HUV) have recently been suggested as a starting material for vascular tissue engineering. HUV possess a functional smooth muscle layer and could be turned into an immunologically inert graft with contractile properties by creating a neoendothelium from the recipient's own cells. This study investigated methods to remove the native endothelium without impairing the contractile function of the smooth muscle layer. These denuded HUV were then seeded with endothelial cells in a perfusion bioreactor, demonstrating the creation of a confluent, shear-resistant neoendothelium
Advantages of human umbilical vein scaffolds derived from cesarean section vs. vaginal delivery for vascular tissue engineering.
The current study investigated whether the mode of delivery and the mode of sample collection affect the functional properties of umbilical veins as scaffolds for vascular tissue engineering purposes. Human umbilical vein (HUV) from planned cesarean-sections (PCS) showed a 1.7-fold higher maximum contraction with potassium chloride compared to spontaneous vaginal deliveries (VDs, p=0.029). The maximum contractions with histamine were 2.0- and 2.9-fold higher in the PCS and emergency c-section (ECS) groups, respectively, compared to the VD group (p=0.003). The dose-response curves of serotonin were shifted to the right approx. 6- and 5-fold in the VD group compared to PCS and ECS, respectively (p=0.009). There were no differences between the birth groups in terms of tetrazolium dye reduction, platelet adhesion, and the structural integrity. The release of the antithrombotic compound prostacyclin from vessels of the PCS and ECS groups was 6.6- and 3.5-fold higher, respectively, than in the VD group (p<0.001). There was no correlation between the duration of ischemia and any of the functional parameters. This study provides evidence that vessels obtained from PCS are to be preferred for tissue engineering purposes, as they can be harvested in a sterile fashion and show superior vasoconstrictor responses and antithrombotic properties. The data also support a once-per-day pickup schedule for umbilical cords without a deterioration of the functional properties