The case for strategic international alliances to harness nutritional genomics for public and personal health

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene-nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient-genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countrie

The Molecular Origin and Taxonomy of Mucinous Ovarian Carcinoma

Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly defined. We perform genetic analysis of MOC across all histological grades, including benign and borderline mucinous ovarian tumors, and compare these to tumors from other potential extra-ovarian sites of origin. Here we show that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC. Key drivers of progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on 9p13. High copy number aberration burden is associated with worse prognosis in MOC. Our data conclusively demonstrate that MOC arise from benign and borderline precursors at the ovary and are not extra-ovarian metastases

Methods for Experimental Social Innovation

X, 250 tr.; 23 cm

An Introduction to community experimentation: theory, methods and practice/ Fairweather

viii, 280 hal.: ill.; 24 cm

An Introduction to community experimentation: theory, methods and practice/ Fairweather

viii, 280 hal.: ill.; 24 cm

An Introduction to community experimentation: theory, methods and practice/ Fairweather

viii, 280 hal.: ill.; 24 cm

An Introduction to community experimentation: theory, methods and practice/ Fairweather

viii, 280 hal.: ill.; 24 cm

An Introduction to community experimentation: theory, methods and practice/ Fairweather

viii, 280 hal.: ill.; 24 cm

An Introduction to community experimentation: theory, methods and practice/ Fairweather

viii, 280 hal.: ill.; 24 cm