1,037 research outputs found
Sustainability in the New England Ski Industry
The goal of this study is to explore the extent to which sustainable investments are worthwhile for the New England ski industry. Research has shown that the New England ski industry will be greatly impacted by the effects of climate change within the near future. Anthropogenic climate change over the next several decades will cause frequent low snow winters, increases in night time winter temperatures, and overall shorter winters. Detailed economic analysis has shown that low snow and warm winters result in roughly $54 million in lost revenue for the New Hampshire ski industry in the past (Burakowski, Magnusson, 2012). However, little research has been done on what ski mountains themselves can do to adapt to and mitigate these impacts. Due to the magnitude of this research question and relatively short time frame for data collection and analysis, this paper represents the beginning of this research. My goal is to identify key sustainability initiatives that have proven successful at New England ski resorts, as well as identify what consumers value when it comes to sustainable investments. This first question is addressed by completing a case study on Jiminy Peak, a net-zero carbon emissions ski mountain in Massachusetts that operates using onsite wind and solar power. The second question is addressed by conducting an online survey with members of the UNH Ski and Board Club. It is my hope that this study will provide New England ski mountains with decision relevant analysis that informs investments and practices so they can prosper in the future
Detecting associations between behavioral addictions and dopamine agonists in the Food & Drug Administration's Adverse Event database
Abstract
Background/Aims
Studies have reported higher prevalences of four behavioral addictions (binge eating, compulsive shopping, hypersexuality, and pathological gambling) in dopamine agonist-treated Parkinson's disease relative to non-dopamine agonist-treated Parkinson's. However, recent case-control and epidemiological studies suggest that prevalences of behavioral addictions in dopamine agonist-treated Parkinson's may be similar to background population rates. This study tests that hypothesis by examining the FDA Adverse Event Reporting System (FAERS) for evidence of these associations, taking into account the potential impact of publicity on reporting rates.
Methods
FAERS reports in 2004 (pre-publicity for all but pathological gambling) and 2007 (post-publicity for all four behaviors) were analyzed. A threshold consisting of ≥3 cases, proportional reporting ratio ≥2, and χ2 with Yates' correction ≥4 was used to detect signals (drug-associated adverse reactions) involving any of five dopamine agonists and any of four behavioral addictions.
Results
No reports containing compulsive shopping and no signal for binge eating and dopamine agonists were found in either year. A weak signal was found for hypersexuality in 2004, with a stronger signal in 2007. A robust signal was found for pathological gambling in 2004, with a more robust signal in 2007.
Discussion/Conclusions
These results suggest that publicity may increase reporting rates in the FAERS. Findings for binge eating, compulsive shopping, and hypersexuality suggest that prevalences of these behaviors among those treated with dopamine agonists may be similar to background population rates and thus may not reflect an adverse safety signal. Further investigation of the relationship between dopamine agonists and behavioral addictions is warranted
Publicity and reports of behavioral addictions associated with dopamine agonists
Background The development of behavioral addictions (BAs) in association with dopamine agonists (DAs, commonly used to treat Parkinson’s disease) has been reported. A recent report presented data that these associations are evident in the US Food and Drug Administration’s (FDA) Adverse Event Reporting System (FAERS), a database containing information on adverse drug event and medication error reports submitted to the FDA. However, given that vulnerability to publicity-stimulated reporting is a potential limitation of spontaneous reporting systems like the FAERS, the potential impact of publicity on reporting in this case remains unclear. Method and aims To investigate the potential impact of publicity on FAERS reporting of BAs in association with DAs (BAs w/DAs) as presented by Moore, Glenmullen, and Mattison (2014), news stories covering a BA/DA association were identified and compared with BA w/DA and other reporting data in the FAERS. Results Fluctuations in the growth of BA w/DA reporting to the FAERS between 2003 and 2012 appear to coincide with multiple periods of intensive media coverage of a BA/DA association, a pattern that is not evident in other reporting data in the FAERS. Discussion/Conclusions Publicity may stimulate reporting of adverse events and premature dismissal of the potential influence of publicity on reporting may lead to mistaking an increased risk of an adverse event being reported for an increased risk of an adverse event occurring
A MIP Model and Several Approaches to Schedule Maintenance in Wind Farms on a Short-term Horizon
Taking into account wind prediction when scheduling maintenance on wind turbines can lead to potential gains. Preemption, transfer times for resources, and outsourcing are considered in this problem. The objective is concerned with maximizing the difference between the profits of wind farms related to the estimated production and the costs associated with outsourcing and resources transfers. A MIP model, a benders decomposition technique and a constraint programming approach are proposed
A Benders-based branch-and-cut approach to solve a wind turbine maintenance scheduling problem
We deal with a maintenance scheduling problem rising in the onshore wind power industry. We address the problem on a short-term horizon considering an individual management of the technicians through a space-time tracking. The objective is to find a maintenance planning that maximizes the production of the turbines while taking into account wind predictions, multiple task execution modes, and task-technician assignment constraints. We introduce an exact method to solve this challenging problem. We first propose integer linear programming (ILP) formulations of this problem. Then, on this basis, we build up a Benders-based branch-and-cut approach making use of Benders cuts as well as problem-specific cuts. Our method solves to optimality most of the instances or delivers solutions with a small average gap with respect to upper bounds. The results suggest that our method significantly outperforms the direct resolution of ILP models
A branch-and-check approach to solve a short-term maintenance scheduling problem faced by the onshore wind industry
International audienc
Maintenance scheduling in the electricity industry: A literature review
The reliability of the power plants and transmission lines in the electricity industry is crucial for meeting demand. Consequently, timely maintenance plays a major role reducing breakdowns and avoiding expensive production shutdowns. By now, the literature contains a sound body of work focused on improving decision making in generating units and transmission lines maintenance scheduling. The purpose of this paper is to review that literature. We update previous surveys and provide a more global view of the problem: we study both regulated and deregulated power systems and explore some important features such as network considerations, fuel management, and data uncertainty
A Persistent Disk Wind in GRS 1915+105 with NICER
The bright, erratic black hole X-ray binary GRS 1915+105 has long been a
target for studies of disk instabilities, radio/infrared jets, and accretion
disk winds, with implications that often apply to sources that do not exhibit
its exotic X-ray variability. With the launch of NICER, we have a new
opportunity to study the disk wind in GRS 1915+105 and its variability on short
and long timescales. Here we present our analysis of 39 NICER observations of
GRS 1915+105 collected during five months of the mission data validation and
verification phase, focusing on Fe XXV and Fe XXVI absorption. We report the
detection of strong Fe XXVI in 32 (>80%) of these observations, with another
four marginal detections; Fe XXV is less common, but both likely arise in the
well-known disk wind. We explore how the properties of this wind depends on
broad characteristics of the X-ray lightcurve: mean count rate, hardness ratio,
and fractional RMS variability. The trends with count rate and RMS are
consistent with an average wind column density that is fairly steady between
observations but varies rapidly with the source on timescales of seconds. The
line dependence on spectral hardness echoes known behavior of disk winds in
outbursts of Galactic black holes; these results clearly indicate that NICER is
a powerful tool for studying black hole winds.Comment: Accepted for publication in ApJL. Comments welcom
A Composite Seyfert 2 X-ray Spectrum: Implications for the Origin of the Cosmic X-ray Background
We present a composite 1-10 keV Seyfert 2 X-ray spectrum, derived from ASCA
observations of a distance-limited sample of nearby galaxies. All 29 observed
objects were detected. Above ~3 keV, the composite spectrum is inverted,
confirming that Seyfert 2 galaxies as a class have the spectral properties
necessary to explain the flat shape of the cosmic X-ray background spectrum.
Integrating the composite spectrum over redshift, we find that the total
emission from Seyfert 2 galaxies, combined with the expected contribution from
unabsorbed type 1 objects, provides an excellent match to the spectrum and
intensity of the hard X-ray background. The principal uncertainty in this
procedure is the cosmic evolution of the Seyfert 2 X-ray luminosity function.
Separate composite spectra for objects in our sample with and without polarized
broad optical emission lines are also presented.Comment: 11 pages (AASTeX), including 3 figures. Accepted for publication in
ApJ Letter
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