Efficacy and Safety of Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy Treated within 6 Months of Disease Onset

Purpose: To evaluate the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects with visual loss from Leber hereditary optic neuropathy (LHON). Design: RESCUE is a multicenter, randomized, double-masked, sham-controlled, phase 3 clinical trial. Participants: Subjects with the m.11778G>A mitochondrial DNA mutation and vision loss ≤6 months from onset in 1 or both eyes were included. Methods: Each subject's right eye was randomly assigned (1:1) to treatment with rAAV2/2-ND4 (single injection of 9 × 1010 viral genomes in 90 μl) or to sham injection. The left eye received the treatment not allocated to the right eye. Main Outcome Measures: The primary end point was the difference of the change from baseline in best-corrected visual acuity (BCVA) between rAAV2/2-ND4–treated and sham-treated eyes at week 48. Other outcome measures included contrast sensitivity, Humphrey visual field perimetry, retinal anatomic measures, and quality of life. Follow-up extended to week 96. Results: Efficacy analysis included 38 subjects. Mean age was 36.8 years, and 82% were male. Mean duration of vision loss at time of treatment was 3.6 months and 3.9 months in the rAAV2/2-ND4–treated eyes and sham-treated eyes, respectively. Mean baseline logarithm of the minimum angle of resolution (logMAR) BCVA (standard deviation) was 1.31 (0.52) in rAAV2/2-ND4–treated eyes and 1.26 (0.62) in sham-treated eyes, with a range from −0.20 to 2.51. At week 48, the difference of the change in BCVA from baseline between rAAV2/2-ND4–treated and sham-treated eyes was −0.01 logMAR (P = 0.89); the primary end point of a −0.3 logMAR (15-letter) difference was not met. The mean BCVA for both groups deteriorated over the initial weeks, reaching the worst levels at week 24, followed by a plateau phase until week 48, and then an improvement of +10 and +9 Early Treatment Diabetic Retinopathy Study letters equivalent from the plateau level in the rAAV2/2-ND4–treated and sham-treated eyes, respectively. Conclusions: At 96 weeks after unilateral injection of rAAV2/2-ND4, LHON subjects carrying the m.11778G>A mutation treated within 6 months after vision loss achieved comparable visual outcomes in the injected and uninjected eyes

Are we ready for genetic testing for primary open-angle glaucoma?

Following a dramatic reduction in the cost of genotyping technology in recent years, there have been significant advances in the understanding of the genetic basis of glaucoma. Glaucoma patients represent around a quarter of all outpatient activity in the UK hospital eye service and are a huge burden for the National Health Service. A potential benefit of genetic testing is personalised glaucoma management, allowing direction of our limited healthcare resources to the glaucoma patients who most need it. Our review aims to summarise recent discoveries in the field of glaucoma genetics and to discuss their potential clinical utility. While genome-wide association studies have now identified over ten genes associated with primary open-angle glaucoma (POAG), individually, variants in these genes are not predictive of POAG in populations. There are data suggesting some of these POAG variants are associated with conversion from ocular hypertension to POAG and visual field progression among POAG patients. However, these studies have not been replicated yet and such genetic testing is not currently justified in clinical care. In contrast, genetic testing for inherited early-onset disease in relatives of POAG patients with a known genetic mutation is of clear benefit; this can support either regular review to commence early treatment when the disease develops, or discharge from ophthalmology services of relatives who do not carry the mutation. Genetic testing for POAG at a population level is not currently justified

Restructuring Local-Level Spatial Planning in Greece Amid the Recession and Recovery Period: Trends and Challenges

The paper examines the restructuring of local-level spatial planning in Greece during and after the crisis period. It analyses the reform paths that were developed and assesses the directions of change concerning the scope of planning, the actors and the practices. The paper concludes that the orientation has turned towards special-purpose planning, the privatisation of planning powers, and the transfer of planning power to the central state. However, despite these shifts, the domestic local-level planning maintains its long trends, such as clientelism and conformative approach, making the trajectory of planning unpredictable. © 2022 Informa UK Limited, trading as Taylor & Francis Group

Setting the grounds for the green infrastructure in the metropolitan areas of athens and thessaloniki: The role of green space

Green Infrastructure (G.I.) is a sine qua non in contemporary planning. Green spaces can play a vital role in serving as grounds for developing G.I. and promoting environmental, social and economic benefits. In Athens and Thessaloniki (the only metropolitan areas in Greece) there has been no Green Infrastructure planning. However, existing and prospective green spaces can play a catalyzing role in the development of a Green Infrastructure. In fact, even though inadequate and insufficiently dispersed, urban green spaces present great potentials for embedding the features of “green”, “connectivity”, “multi-functionality” and “accessibility”, which are key to G.I. planning. The concept of Green Infrastructure has long been embedded in policy documents, such as the Master Plans of both metropolitan areas. And even if the G.I. term is not clearly stated in either Master Plans, there is a clear goal for the designing and networking of green spaces, to provide leisure opportunities and other functions, as well as accessibility to all citizens. © 2018 The Authors

Public’s perceptions of urban identity of Thessaloniki, Greece

Urban identity (UI) is a multi-faceted concept that encompasses different aspects of urban environment, built heritage and natural environment and is also related to important properties of the cities. The paper studies the associations between the inhabitants’ perceptions of UI and their socio-demographic profile. The city of Thessaloniki is the case study of this research. The research was based on data collection via structured questionnaires, and the results were statistically analyzed using: descriptive statistics, χ2 analysis, crosstabs method, regression analysis and discriminant analysis. The results show that UI, being a generally unknown term to the public, incorporates the notions of history and culture, urban environment, social behavior and everyday life, and it is influenced by social and economic factors. The perceptions on the city’s identity are associated with gender, age and family status, as well as the way people spend their spare time. It emerges that, in Thessaloniki, a policy mix is necessary to preserve and upgrade the historical assets of the city, along with the improvement of its every day functions. © 2021, The Author(s), under exclusive licence to Springer Nature Limited

Energy use and saving in residential sector and occupant behavior: A case study in Athens

Summarization: In Greece, energy use in the residential sector corresponds to 24.4% of the total energy use in 2014, showing an increase of 13.8% in the period 1995–2014. Although the technical characteristics of a building have a significant impact on residential energy use, the behavior of the occupant is also crucial. Our aim is to investigate the interrelationships between the energy use behavior of occupants and their socio-demographic characteristics. The data used for this study were collected through a structured questionnaire. The survey was conducted during the spring of 2016 in the city of Athens. 451 people responded. The questionnaire comprised three parts: (a) building characteristics, (b) occupants' behavior, and (c) socio-demographic profile of occupants. Principal component analysis (PCA) was used to identify the behavioral patterns (components) of occupants. Six energy behavioral patterns are identified: (a) environmentally aware, (b) environmentally friendly, (c) adopting energy saving practices, (d) having economic motivation behind energy saving practices, (e) environmentally uninvolved, and (f) environmentally unaware. These types are correlated with the socio-demographic profile of occupants highlighting the importance of gender, age, educational level, number of members per household and income in energy use and saving. In conclusion, energy behavior is quite complex and it is strongly associated with the socio-demographic characteristics. Within this context, policies regarding the improvement of energy use in residential sector should be tailored to specific needs of the target population groups. The three main axes are the increase of education level, the increase of environmental awareness of young people and the provision of financial incentives for the retrofit of energy saving devices for the citizens with lower income.Presented on: Energy and Building

Three Year Outcomes of Aflibercept Treatment for Neovascular Age-Related Macular Degeneration: Evidence from a Clinical Setting

<p></p><p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>. </b><a href="https://link.springer.com/article/10.1007/s40123-018-0139-5">https://link.springer.com/article/10.1007/s40123-018-0139-5</a></p><p></p><p></p><p> </p><p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p><br><p></p