Focusing of quantum gate interactions using dynamical decoupling

In 1995, Cirac and Zoller proposed the first concrete implementation of a small-scale quantum computer, using laser beams focused to micron spot sizes to address individual trapped ions in a linear crystal. Here we propose a method to focus entangling gate interactions, but driven by microwave fields, to micron-sized zones, corresponding to $10^{-5}$ microwave wavelengths. We demonstrate the ability to suppress the spin-dependent force using a single ion, and find the required interaction introduces $3.7(4)\times 10^{-4}$ error per emulated gate in a single-qubit benchmarking sequence. We model the scheme for a 17-qubit ion crystal, and find that any pair of ions should be addressable with an average crosstalk error of $\sim 10^{-5}$

Estudio de isotermas de adsorción de cebada cervecera (<i>Hordeum distichum</i> L.)

Se determinaron las isotermas de adsorción de semillas de cebada cervecera (var. Scarllet) empleando el método gravimétrico estático a diferentes temperaturas (20, 30, 40 y 50ºC) utilizando soluciones de sales saturadas (LiCl, MgCl₂.6H₂O, K₂CO₃, NaBr, NaNO₂, KI, NaNO₃, NaCl, (NH₄)₂SO₄) para proporcionar una actividad de agua para cada temperatura comprendida entre 0.11 y 0.813. Se verificó la presencia de ciclos de histéresis entre las isotermas de adsorción / desorción. Según la clasificación de ciclos de histéresis IUPAC, los ciclos de cebada son del tipo H3. Se utilizaron las ecuaciones modificadas de Henderson, (MHE), Chung-Pfost (MCPE), Halsey (MHaE) y de Oswin (MOE), para evaluar su capacidad de ajustar los datos experimentales de EMC/ERH. La comparación se hizo teniendo en cuenta el error estándar de la estimación (SE), y el coeficiente de determinación (R²) siendo la ecuación modificada de Oswin la más apropiada para modelar las isotermas de adsorción de cebada cervecera var. Scarlett.Centro de Investigación y Desarrollo en Criotecnología de Alimento

Toxicokinetics of bisphenol-S and its glucuronide in plasma and urine following oral and dermal exposure in volunteers for the interpretation of biomonitoring data

The measurement of bisphenol-S (BPS) and its glucurono-conjugate (BPSG) in urine may be used for the biomonitoring of exposure in populations. However, this requires a thorough knowledge of their toxicokinetics. The time courses of BPS and BPSG were assessed in accessible biological matrices of orally and dermally exposed volunteers. Under the approval of the Research Ethics Committee of the University of Montreal, six volunteers were orally exposed to a BPS-d8 deuterated dose of 0.1 mg/kg body weight (bw). One month later, 1 mg/kg bw of BPS-d8 were applied on 40 cm2 of the forearm and then washed 6 h after application. Blood samples were taken prior to dosing and at fixed time periods over 48 h after treatment; complete urine voids were collected pre-exposure and at pre-established intervals over 72 h postdosing. Following oral exposure, the plasma concentration–time courses of BPS-d8 and BPSG-d8 over 48 h evolved in parallel, and showed a rapid appearance and elimination. Average peak values (±SD) were reached at 0.7 ± 0.1 and 1.1 ± 0.4 h postdosing and mean (±SD) apparent elimination half-lives (t½) of 7.9 ± 1.1 and 9.3 ± 7.0 h were calculated from the terminal phase of BPS-d8 and BPSG-d8 in plasma, respectively. The fraction of BPS-d8 reaching the systemic circulation unchanged (i.e. bioavailability) was further estimated at 62 ± 5% on average (±SD) and the systemic plasma clearance at 0.57 ± 0.07 L/kg bw/h. Plasma concentration–time courses and urinary excretion rate profiles roughly evolved in parallel for both substances, as expected. The average percent (±SD) of the administered dose recovered in urine as BPS-d8 and BPSG-d8 over the 0–72 h period postdosing was 1.72 ± 1.3 and 54 ± 10%. Following dermal application, plasma levels were under the lower limit of quantification (LLOQ) at most time points. However, peak values were reached between 5 and 8 h depending on individuals, suggesting a slower absorption rate compared to oral exposure. Similarly, limited amounts of BPS-d8 and its conjugate were recovered in urine and peak excretion rates were reached between 5 and 11 h postdosing. The average percent (±SD) of the administered dose recovered in urine as BPS-d8 and BPSG-d8 was about 0.004 ± 0.003 and 0.09 ± 0.07%, respectively. This study provided greater precision on the kinetics of this contaminant in humans and, in particular, evidenced major differences between BPA and BPS kinetics with much higher systemic levels of active BPS than BPA, an observation explained by a higher oral bioavailability of BPS than BPA. These data should also be useful in developing a toxicokinetic model for a better interpretation of biomonitoring data

Phase angle by electrical bioimpedance is a predictive factor of hospitalisation, falls and mortality in patients with cirrhosis

The phase angle is a versatile measurement to assess body composition, frailty and prognosis in patients with chronic diseases. In cirrhosis, patients often present alterations in body composition that are related to adverse outcomes. The phase angle could be useful to evaluate prognosis in these patients, but data are scarce. The aim was to analyse the prognostic value of the phase angle to predict clinically relevant events such as hospitalisation, falls, and mortality in patients with cirrhosis. Outpatients with cirrhosis were consecutively included and the phase angle was determined by electrical bioimpedance. Patients were prospectively followed to determine the incidence of hospitalisations, falls, and mortality. One hundred patients were included. Patients with phase angle ≤ 4.6° (n = 31) showed a higher probability of hospitalisation (35% vs 11%, p = 0.003), falls (41% vs 11%, p = 0.001) and mortality (26% vs 3%, p = 0.001) at 2-year follow-up than patients with PA > 4.6° (n = 69). In the multivariable analysis, the phase angle and MELD-Na were independent predictive factors of hospitalisation and mortality. Phase angle was the only predictive factor for falls. In conclusion, the phase angle showed to be a predictive marker for hospitalisation, falls, and mortality in outpatients with cirrhosis