Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion

Glucocorticoids are associated with stress. Here, the authors show that high levels of glucocorticoid stress promote secretory autophagy of matrix metalloproteinase 9 via a stress responsive chaperone, increasing brain-derived neurotrophic factor processing and potentially altering adult synaptic plasticity

Naturalizing the essential tension

Kuhn’s “essential tension” between conservative and innovative imperatives in enquiry has an empirical analogue—between the potential benefits of collectivization of enquiry and the social dynamic impediments to effective sharing of information and insights in collective settings. A range of empirical materials from social psychology and organization theory are considered which bear on the issue of balancing these opposing forces and an institution is described in which they are balanced in a way which is appropriate for collective knowledge production

Arctic state, Arctic nation? Arctic national identity among the post-Cold War generation in Norway

\ua9 2014,Taylor & Francis. In Norway, the Arctic has taken centre stage as a primary political priority. Claiming status as an ‘Arctic state’ may not be controversial based on formal geographical and legal definitions; however, the way in which the Arctic has thus been incorporated in the public\u27s sense of Norwegian national identity is less clear. Against the background of the Norwegian government\u27s discursive construction of a national Arctic identity in its High North strategy, this study assesses the reception this official identity has received. Over 200 young Norwegians, having largely grown up in a post-Cold War world marked by rapidly changing Arctic climate and geopolitics, were asked about their sense of Arctic identity. Contrary to governmental efforts to frame the Arctic as a fundamentally national matter, the respondents\u27 insights highlight the multifaceted nature of identities, as a sense of Arctic identity contextually shifts between sub-national, national and supranational scales. This study thus suggests a balancing act faced by states across the region as they seek to legitimize state-level primacy and national unity in the circumpolar North