The Association between Residence Floor Level and Cardiovascular Disease: The Health and Environment in Oslo Study

Background. Increasingly more people live in tall buildings and on higher floor levels. Factors relating to floor level may protect against or cause cardiovascular disease (CVD). Only one previous study has investigated the association between floor level and CVD. Methods. We studied associations between floor of bedroom and self-reported history of stroke, venous thromboembolism (VTE), and intermittent claudication (IC) among 12.525 inhabitants in Oslo, Norway. We fitted multivariate logistic regression models and adjusted for sociodemographic variables, socioeconomic status (SES), and health behaviors. Additionally, we investigated block apartment residents ( = 5.374) separately. Results. Trend analyses showed that disease prevalence increased by floor level, for all three outcomes. When we investigated block apartment residents alone, the trends disappeared, but one association remained: higher odds of VTE history on 6th floor or higher, compared to basement and 1st floor (OR: 1.504; 95% CI: 1.007-2.247). Conclusion. Floor level is positively associated with CVD, in Oslo. The best-supported explanation may be residual confounding by building height and SES. Another explanation, about the impact of atmospheric electricity, is also presented. The results underline a need to better understand the associations between residence floor level and CVD and multistory housing and CVD

The role of occupational meaningfulness and citizenship as mediators between occupational status and recovery: a cross-sectional study among residents with co-occurring problems

Purpose Engagement in meaningful occupations and being included as full citizens of the community, is essential in everyday life, and may be of considerable relevance for recovery and quality of life. However, persons with co-occurring substance use and mental health problems experience extensive obstacles to engagement in occupations and citizenship. The relationship between objective measures of occupational status and subjective experiences of occupational meaningfulness, citizenship and recovery, is scarcely researched in the context of co-occurring problems. As such, the purpose of this study is to examine associations between occupational status, occupational meaningfulness, citizenship and recovery and quality of life and to examine the roles of occupational meaningfulness and citizenship as possible mediators between occupational status and recovery and quality of life. Design/methodology/approach The study used a cross-sectional design with a sample of 104 residents at supported housing sites across six Norwegian cities. Findings Linear regression analyzes indicated that occupational status was significantly associated with the citizenship domains caring for others and community participation and with the quality of life measure positive affect. Occupational meaningfulness and citizenship were significantly associated with different domains of recovery and quality of life. Furthermore, mediation analyzes showed that the relationship between occupational status and recovery and quality of life was mediated by caring for others and community participation. Originality/value The results suggest that emphasizing opportunities for occupational meaningfulness and citizenship in practice may have positive implications for recovery among persons with co-occurring problems.acceptedVersio

Is Green Exercise for All? A Descriptive Study of Green Exercise Habits and Promoting Factors in Adult Norwegians

This is an Open Access article licensed under the Creative Commons Attribution License 3.0 (CC BY 3.0) and originally published in International Journal of Environmental Research and Public Health. You can access the article by following this link: http://dx.doi.org/10.3390/ijerph13111165Dette er en vitenskapelig, fagfellevurdert artikkel som opprinnelig ble publisert i International Journal of Environmental Research and Public Health. Artikkelen er publisert under lisensen Creative Commons Attribution License 3.0 (CC BY 3.0) . Du kan også få tilgang til artikkelen ved å følge denne lenken: http://dx.doi.org/10.3390/ijerph13111165Background: Physical activity (PA) in natural environments, known as green exercise (GE), can provide health benefits above and beyond PA in other environments, but little is known about the extent to which GE is an accessible form of weekly PA across different social groups. This study aims to examine the “GE phenomenon” in Norway, and evaluate possible differences in GE habits and perceived factors that promote GE across sub-groups of this population. Methods: 2168 adults from all over Norway reported weekly GE and other forms of PA, specific forms of GE, and perceived factors that promote GE. Data were examined in the overall sample and in relation with the respondents’ PA status and sociodemographic characteristics. Results: GE, especially “walking in the forest” and “activities by/on the sea”, was the most popular form of weekly PA, even among those with low PA levels. GE was fairly represented across all social groups, and especially among the elderly, those who live with spouse/partner and those who live in the west regions of Norway, while no associations were found in relation to sex, centrality, education level or household income. “Time flexibility” and “PA-supportive places” were generally perceived as the most important factors that promote GE across all social groups. “Accessibility to nature” was generally perceived relatively little important, though a gradient was observed in relation to age, education level and household income. Conclusions: GE is an important source of weekly PA and health among adult Norwegians, especially in sub-groups of interest for public health such as the elderly, those with lower socio-economic status and those who live in non-urban areas. More should be done to understand and address the inequities relative to the perceived accessibility to nature

Forekomst av seksuell trakassering av tenåringer og sammenhengen med depressive symptomer. Hvilken betydning har sosiale relasjoner?

publishedVersio

The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma

The E-cadherin-catenin complex provides cell-cell adhesion. In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor. The presence of components of the E-cadherin-catenin complex in 246 rectal adenocarcinomas was examined by immunohistochemistry and compared to their presence in 219 colon carcinomas. The expression data were correlated to clinical information from the patients' records. There were statistically significant differences in protein expression between the rectal and the colon carcinomas regarding membranous β-catenin, γ-catenin, p120-catenin, and E-cadherin, as well as nuclear β-catenin. In the rectal carcinomas, there was a significant inverse association between the expression of p120-catenin in cell membranes of the primary tumors and the occurrence of local recurrence, while membranous protein expression of β-catenin was inversely related to distant metastases

Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas

Adenocarcinomas of rectum and colon may be different with regard to the cellular biological basis for cancer development. A material of 246 rectal cancers removed surgically at Akershus University Hospital in the years 1992–2000 was investigated and was compared to a material of 219 colon cancers operated on at Akershus University Hospital during the years 1988, 1990 and 1997–2000. There were highly significant differences between the rectal and the colon cancers in the protein expression of cyclin D1, cyclin D3, cyclin E, nuclear β-catenin, and c-Myc and in gene amplification of cyclin A2, cyclin B1, cyclin D1, and cyclin E. Gene amplification and protein expression in the rectal cancers correlated significantly for the cyclins B1, D3, and E. A statistically significant relation was observed between overexpression of cyclin A2 and local relapse of rectal carcinomas, as higher expression of cyclin A2 was associated with lower local recurrence rate

Geographical variation in cardiovascular disease mortality in Norway: The role of life course socioeconomic position and parental health

Despite substantial geographical variation in cardiovascular (CVD) mortality within countries, little is known about whether this variation can be explained by individuals' life course socioeconomic position (SEP) or differences in family history of premature CVD deaths. Cox proportional hazards models were used to investigate the association between the county of residence at ages 50–59 and CVD death in Norwegians born between 1940 and 1959 and survived to at least age 60, using national data. Individual life course SEP and family history of premature CVD death reduced the geographical variation in CVD mortality across Norwegian counties, but some significant differences remained. Furthermore, CVD risk varied by residents' migration histories between two counties with distinct CVD and socioeconomic profiles.Geographical variation in cardiovascular disease mortality in Norway: The role of life course socioeconomic position and parental healthpublishedVersio

Wear and Migration of Highly Cross-Linked and Conventional Cemented Polyethylene Cups with Cobalt Chrome or Oxinium Femoral Heads: A Randomized Radiostereometric Study of 150 Patients

ABSTRACT: This randomized study was performed to compare wear and migration of five different cemented total hip joint articulations in 150 patients. The patients received either a Charnley femoral stem with a 22.2 mm head or a Spectron EF femoral stem with a 28 mm head. The Charnley articulated with a g-sterilized Charnley Ogee acetabular cup. The Spectron EF was used with either EtOsterilized non-cross-linked polyethylene (Reflection All-Poly) or highly cross-linked (Reflection All-Poly XLPE) cups, combined with either cobalt chrome (CoCr) or Oxinium femoral heads. The patients were followed with repeated RSA measurements for 2 years. After 2 years, the EtO-sterilized non-cross-linked Reflection All-Poly cups had more than four times higher proximal penetration than its highly cross-linked counterpart. Use of Oxinium femoral heads did not affect penetration at 2 years compared to heads made of CoCr. Further follow-up is needed to evaluate the benefits, if any, of Oxinium femoral heads in the clinical setting. The Charnley Ogee was not outperformed by the more recently introduced implants in our study. We conclude that this prostheses still represents a standard against which new implants can be measured. Osteolysis induced by wear debris of ultra-high molecular weight polyethylene (UHMWPE) is considered the most common cause for failure of total hip arthroplasties (THA). 1 Sterilization technique and UHMWPE quality are related to wear. 2 Sterilization with gamma irradiation in air breaks the polymer chains and generates free radicals. Free radicals may combine with each other creating cross-links between adjacent molecules, which reduces abrasive wear. However, they entail the disadvantage of oxidative degradation of polyethylene (PE) when exposed to the body's oxidative environment, which may lead to deterioration of mechanical properties. 3 To address the problem, sterilization methods in inert environments with ethylene oxide (EtO) or gas plasma were introduced. However, these methods do not have the benefits of cross-linking, and an earlier report showed increase in early in vivo wear after EtO sterilization. 4 Highly cross-linked polyethylenes (HXLPE) provides a considerable reduction of wear compared to conventional polyethylene (PE). Concerns of PE wear have also been addressed by introducing alternative femoral head materials. Oxidized zirconium (Oxinium, Smith & Nephew) was introduced in the last decade for use in THA. Radiostereometric analysis (RSA) enables in vivo measurement of relative 3D motion in the range of 0.1 mm and 0.058. Due to its accuracy, few patients are needed to obtain satisfactory statistical power. With RSA the degree of migration during the first years after surgery correlates with the implant's longterm performance. We wanted to evaluate wear and migration patterns of the cemented highly cross-linked Reflection All-Poly XLPE cup and its non-irradiated counterpart, the cemented Reflection All-Poly cup, when articulating with either Oxinium or traditional cobalt chrome (CoCr) femoral heads (Smith & Nephew). Our null hypothesis was that wear and migration were equal to the Charnley Ogee prostheses (DePuy Intl