Human helminth co-infection: analysis of spatial patterns and risk factors in a Brazilian community.

BACKGROUND: Individuals living in areas endemic for helminths are commonly infected with multiple species. Despite increasing emphasis given to the potential health impacts of polyparasitism, few studies have investigated the relative importance of household and environmental factors on the risk of helminth co-infection. Here, we present an investigation of exposure-related risk factors as sources of heterogeneity in the distribution of co-infection with Necator americanus and Schistosoma mansoni in a region of southeastern Brazil. METHODOLOGY: Cross-sectional parasitological and socio-economic data from a community-based household survey were combined with remotely sensed environmental data using a geographical information system. Geo-statistical methods were used to explore patterns of mono- and co-infection with N. americanus and S. mansoni in the region. Bayesian hierarchical models were then developed to identify risk factors for mono- and co-infection in relation to community-based survey data to assess their roles in explaining observed heterogeneity in mono and co-infection with these two helminth species. PRINCIPAL FINDINGS: The majority of individuals had N. americanus (71.1%) and/or S. mansoni (50.3%) infection; 41.0% of individuals were co-infected with both helminths. Prevalence of co-infection with these two species varied substantially across the study area, and there was strong evidence of household clustering. Hierarchical multinomial models demonstrated that relative socio-economic status, household crowding, living in the eastern watershed and high Normalized Difference Vegetation Index (NDVI) were significantly associated with N. americanus and S. mansoni co-infection. These risk factors could, however, only account for an estimated 32% of variability between households. CONCLUSIONS: Our results demonstrate that variability in risk of N. americanus and S. mansoni co-infection between households cannot be entirely explained by exposure-related risk factors, emphasizing the possible role of other household factors in the heterogeneous distribution of helminth co-infection. Untangling the relative contribution of intrinsic host factors from household and environmental determinants therefore remains critical to our understanding of helminth epidemiology

Analysis of the nature of the ϕ→γπη\phi\to\gamma\pi\eta and ϕ→γπ0π0\phi\to\gamma\pi^0\pi^0 decays

We study interference patterns in the $\phi\to(\gamma a_0+\pi^0\rho)\to\gamma\pi\eta$ and $\phi\to(\gamma f_0+\pi^0\rho)\to\gamma \pi^0\pi^0$ reactions. Taking into account the interference, we fit the experimental data and show that the background reaction does not distort the $\pi^0\eta$ spectrum in the decay $\phi\to\gamma\pi\eta$ everywhere over the energy region and does not distort the $\pi^0\pi^0$ spectrum in the decay $\phi\to\gamma\pi^0\pi^0$ in the wide region of the $\pi^0\pi^0$ system invariant mass, $m_{\pi\pi}>670$ MeV, or when the photon energy is less than 300 MeV. We discuss the details of the scalar meson production in the radiative decays and note that there are reasonable arguments in favor of the one-loop mechanism $\phi\to K^+K^-\to\gamma a_0$ and $\phi\to K^+K^-\to\gamma f_0$. We discuss also distinctions between the four-quark, molecular, and two-quark models and argue that the Novosibirsk data give evidence in favor of the four-quark nature of the scalar $a_0(980)$ and $f_0(980)$ mesons.Comment: 15 pages, 7 figures, title is changed, a few clarifying remarks are added, accepted for publication in Physical Review

K* nucleon hyperon form factors and nucleon strangeness

A crucial input for recent meson hyperon cloud model estimates of the nucleon matrix element of the strangeness current are the nucleon-hyperon-K* (NYK*) form factors which regularize some of the arising loops. Prompted by new and forthcoming information on these form factors from hyperon-nucleon potential models, we analyze the dependence of the loop model results for the strange-quark observables on the NYK* form factors and couplings. We find, in particular, that the now generally favored soft N-Lambda-K* form factors can reduce the magnitude of the K* contributions in such models by more than an order of magnitude, compared to previous results with hard form factors. We also discuss some general implications of our results for hadronic loop models.Comment: 9 pages, 8 figures, new co-author, discussion extended to the momentum dependence of the strange vector form factor

Strange chiral nucleon form factors

We investigate the strange electric and magnetic form factors of the nucleon in the framework of heavy baryon chiral perturbation theory to third order in the chiral expansion. All counterterms can be fixed from data. In particular, the two unknown singlet couplings can be deduced from the parity-violating electron scattering experiments performed by the SAMPLE and the HAPPEX collaborations. Within the given uncertainties, our analysis leads to a small and positive electric strangeness radius, $= (0.05 \pm 0.09) fm^2$. We also deduce the consequences for the upcoming MAMI A4 experiment.Comment: 7 pp, REVTeX, uses epsf, minor correction

Positive Parity Scalar Mesons in the 1-2 GeV Mass Range

Based on the observation that K_0(1430) is lighter than its SU_3 counterpart, a_0(1450), we examine the possibility that these particles, together with f_0(1370), f_0(1500) and f_0(1710), fill a tetraquark recurrence of the sub-GeV 0^{++} nonet mixed with a glueball state. We find the picture to be consistent with the known data about the three f_0 resonances, more than the q-qbar hypothesis. Conventional spin-orbit coupling suggests the q-qbar, P-wave, nonet to lie around 1200 MeV. We review possible experimental indications of a scalar isovector resonance at 1.29 GeV, first observed by OBELIX in p-pbar annihilation.Comment: 12 pages, 9 figures. Extended version. References added. Results and conclusions unchange

Octet magnetic moments and the Coleman-Glashow sum rule violation in the chiral quark model

Baryon octet magnetic moments when calculated within the chiral quark model, incorporating the orbital angular momentum as well as the quark sea contribution through the Cheng-Li mechanism, not only show improvement over the non relativistic quark model results but also gives a non zero value for the right hand side of Coleman-Glashow sum rule. When effects due to spin-spin forces between constituent quarks as well as `mass adjustments' due to confinement are added, it leads to an excellent fit for the case of p, \Sigma^+, \Xi^o and violation of Coleman-Glashow sum rule, whereas in almost all the other cases the results are within 5% of the data.Comment: 5 RevTeX pages, accepted for publication in PRD(Rapid Communication

Heavy Flavor Hadrons in Statistical Hadronization of Strangeness-rich QGP

We study b, c quark hadronization from QGP. We obtain the yields of charm and bottom flavored hadrons within the statistical hadronization model. The important novel feature of this study is that we take into account the high strangeness and entropy content of QGP, conserving strangeness and entropy yields at hadronization.Comment: v2 expended: 20 pages, 23 figures, 5 tables, in press EPJ-

Strange Hadronic Loops of the Proton: A Quark Model Calculation

Nontrivial $q \bar q$ sea effects have their origin in the low-$Q^2$ dynamics of strong QCD. We present here a quark model calculation of the contribution of $s \bar s$ pairs arising from a {\it complete} set of OZI-allowed strong $Y^*K^*$ hadronic loops to the net spin of the proton, to its charge radius, and to its magnetic moment. The calculation is performed in an ``unquenched quark model" which has been shown to preserve the spectroscopic successes of the naive quark model and to respect the OZI rule. We speculate that an extension of the calculation to the nonstrange sea will show that most of the ``missing spin" of the proton is in orbital angular momenta.Comment: revtex, 34 pages, 4 figure

Sensitivity of HBT interferometry to the microscopic dynamics of freeze-out

We study the HBT interferometry of ultra-relativistic nuclear collisions using a freezeout model in which free pions emerge in the course of the last binary collisions in the hadron gas. We show that the HBT correlators of both identical and non-identical pions change with respect to the case of independent pion production. Practical consequences for the design of the event generator with the built in Bose-Einstein correlations are discussed. We argue that the scheme of inclusive measurement of the HBT correlation function does not require the symmetrization of the multi-pion transition amplitudes (wave-functions).Comment: 22 pages, 3 epsf figures, RevTe