Social Engineering

Manipulative communication—from early twentieth-century propaganda to today's online con artistry—examined through the lens of social engineering. The United States is awash in manipulated information about everything from election results to the effectiveness of medical treatments. Corporate social media is an especially good channel for manipulative communication, with Facebook a particularly willing vehicle for it. In Social Engineering, Robert Gehl and Sean Lawson show that online misinformation has its roots in earlier techniques: mass social engineering of the early twentieth century and interpersonal hacker social engineering of the 1970s, converging today into what they call “masspersonal social engineering.” As Gehl and Lawson trace contemporary manipulative communication back to earlier forms of social engineering, possibilities for amelioration become clearer. The authors show how specific manipulative communication practices are a mixture of information gathering, deception, and truth-indifferent statements, all with the instrumental goal of getting people to take actions the social engineer wants them to. Yet the term “fake news,” they claim, reduces everything to a true/false binary that fails to encompass the complexity of manipulative communication or to map onto many of its practices. They pay special attention to concepts and terms used by hacker social engineers, including the hacker concept of “bullshitting,” which the authors describe as a truth-indifferent mix of deception, accuracy, and sociability. They conclude with recommendations for how society can undermine masspersonal social engineering and move toward healthier democratic deliberation

Hybrid-learning for social design

Underlying causes of conflict, inequity, and injustice remain deeply entrenched in the lives of people ranging from impoverished villages to overpopulated megalopolises. To help address these complex issues, social design brings together designers from varying disciplines to address the needs of the community. While universities across the world recognize the need to introduce social design pedagogy into their curriculum, many programs remain confined within Western post-graduate education. In response, two multidisciplinary professors initiated a team-taught \u27Design for Social Change\u27 course in an undergraduate design program in Dubai, UAE. Open to students across disciplines, the course followed a hybrid-learning approach to planning, conducting, and evaluating learning activities. The methodology empowered students to determine their project interest, cooperatively build research, and value their diverse skills. This paper introduces the notion of hybrid-learning, collabor-active team-teaching in an interdisciplinary classroom, and applies the methodology to a social design course in the MENA region. This paper has been presented as part of the Tasmeem Exploration Platform during Tasmeem Conference, Doha, 2013

Energy End-Use Technologies for the 21st Century. A Report of the World Energy Council

This report makes clear the opportunities and places technology development firmly centre stage in meeting and overcoming the challenges confronting the energy industry and policy makers. Energy End-Use Technologies for the 21st Century makes it crystal clear that technologies deployed in 20 to 50 years will be the result of policy and funding decisions taken now and that we cannot afford to duck these decisions if we are to meet the World Energy Council’s goals of energy availability, accessibility and acceptability

Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae

BACKGROUND: Nutrient minerals are essential yet potentially toxic, and homeostatic mechanisms are required to regulate their intracellular levels. We describe here a genome-wide screen for genes involved in the homeostasis of minerals in Saccharomyces cerevisiae. Using inductively coupled plasma-atomic emission spectroscopy (ICP-AES), we assayed 4,385 mutant strains for the accumulation of 13 elements (calcium, cobalt, copper, iron, potassium, magnesium, manganese, nickel, phosphorus, selenium, sodium, sulfur, and zinc). We refer to the resulting accumulation profile as the yeast 'ionome'. RESULTS: We identified 212 strains that showed altered ionome profiles when grown on a rich growth medium. Surprisingly few of these mutants (four strains) were affected for only one element. Rather, levels of multiple elements were altered in most mutants. It was also remarkable that only six genes previously shown to be involved in the uptake and utilization of minerals were identified here, indicating that homeostasis is robust under these replete conditions. Many mutants identified affected either mitochondrial or vacuolar function and these groups showed similar effects on the accumulation of many different elements. In addition, intriguing positive and negative correlations among different elements were observed. Finally, ionome profile data allowed us to correctly predict a function for a previously uncharacterized gene, YDR065W. We show that this gene is required for vacuolar acidification. CONCLUSION: Our results indicate the power of ionomics to identify new aspects of mineral homeostasis and how these data can be used to develop hypotheses regarding the functions of previously uncharacterized genes

Integrated photonic structures for photon-mediated entanglement of trapped ions

Trapped atomic ions are natural candidates for quantum information processing and have the potential to realize or improve quantum computing, sensing, and networking. These applications often require the collection of individual photons emitted from ions into guided optical modes, in some cases for the production of entanglement between separated ions. Proof-of-principle demonstrations of such photon collection from trapped ions have been performed using high-numerical-aperture lenses and single-mode fibers, but integrated photonic elements in ion-trap structures offer advantages in scalability and manufacturabilty over traditional optics. In this paper we analyze structures monolithically fabricated with an ion trap for collecting single photons from ions, coupling them into integrated waveguides, and manipulating them via interference. We discuss practical considerations for realizing photon-mediated entanglement between trapped ions using these waveguide-based devices.Comment: 17 pages, 6 figures, 2 table

Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy – spatial and time dependent distribution

BACKGROUND: Electroporation is currently receiving much attention as a way to increase drug and DNA delivery. Recent studies demonstrated the feasibility of electrogene therapy using a range of therapeutic genes for the treatment of experimental tumors. However, the transfection efficiency of electroporation-assisted DNA delivery is still low compared to viral methods and there is a clear need to optimize this approach. In order to optimize treatment, knowledge about spatial and time dependency of gene expression following delivery is of utmost importance in order to improve gene delivery. Intravital microscopy of tumors growing in dorsal skin fold window chambers is a useful method for monitoring gene transfection, since it allows non-invasive dynamic monitoring of gene expression in tumors in a live animal. METHODS: Intravital microscopy was used to monitor real time spatial distribution of the green fluorescent protein (GFP) and time dependence of transfection efficiency in syngeneic P22 rat tumor model. DNA alone, liposome-DNA complexes and electroporation-assisted DNA delivery using two different sets of electric pulse parameters were compared. RESULTS: Electroporation-assisted DNA delivery using 8 pulses, 600 V/cm, 5 ms, 1 Hz was superior to other methods and resulted in 22% increase in fluorescence intensity in the tumors up to 6 days post-transfection, compared to the non-transfected area in granulation tissue. Functional GFP was detected within 5 h after transfection. Cells expressing GFP were detected throughout the tumor, but not in the surrounding tissue that was not exposed to electric pulses. CONCLUSIONS: Intravital microscopy was demonstrated to be a suitable method for monitoring time and spatial distribution of gene expression in experimental tumors and provided evidence that electroporation-assisted gene delivery using 8 pulses, 600 V/cm, 5 ms, 1 Hz is an effective method, resulting in early onset and homogenous distribution of gene expression in the syngeneic P22 rat tumor model

Green Urbanism and its Application to Singapore

Green urbanism has been applied to cities but not in Asia. Seven characteristics of green urbanism are outlined and then applied to Singapore. The Renewable City is not yet a concept for Singapore. The Carbon Neutral City is being developed for an island Palau Ubin and by some firms but not to significant sectors or parts of urban Singapore. The Distributed City is being developed around Singapore’s polycentric model but needs specific infrastructure plans similar to ones developed by Singapore for Tianjin Eco-City. The Biophillic City is being developed as a world first through its Skyrise Greenery initiative and urban landscaping. The Eco-Efficient City is also being demonstrated through Singapore closing the loop on their water and solid waste systems. The Place Based City is very evident in all its 22 sub centres. And the Sustainable Transport City is an Asian leader in integrated transport planning though there are signs of this becoming harder to achieve