Naringin a potent antioxidant used as bioavailibility enhancer for terbinafine hydrochloride

The poor bioavailability of drugs has been identified as the single most important challenge in oral drug delivery. Prominent among the factors responsible for this are the oxidative metabolic activity of the intestinal and hepatic cytochrome P450 enzyme family. Naringin and naringenin which are the major phytochemical component of grapefruit juice, a well-known cytochrome P450 3A4 inhibitor and flavone glycoside, is antioxidant in nature and occurs naturally in the pericarp of citrus fruit, and particularly of grapefruit (Citrus paradisii) where it is the predominant flavonoid found and is responsible for the bitter taste associated with the fruit. CYP3A4 which is a class of CYP – 450 (microsomal enzyme) is responsible for the oxidative metabolic reaction of various substrates which decreases the bioavailability of drug

Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system

Design and in vitro evaluation of mouth dissolving tablets olanzapine

The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets.  The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactor

Development and characterization of surface solid dispersion of curcumin for solubility enhancement

Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes. &nbsp

A review on solid dispersion: a modern formulation approach in drug delivery system

Drugs those are given as solid dosage form and having low solubility often have a lack of flexibility in drug formulation and administration. The dissolution rate could be the rate-limiting process in the absorption of a drug from a solid dosage form of relatively insoluble drugs. Solid dispersion technologies are promising techniques for improving the water solubility, and hence dissolution and bioavailability of hydrophobic drugs. It is done for Biopharmaceutical Classification System (BCS) II Class drugs. Solid dispersion is the dispersion of one or more active ingredients in hydrophilic inert carrier matrix at molecular level. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. The focus of this review article is on advantages, disadvantages and the method of preparation, and characterization of the solid dispersion. This review also discusses the recent advances in the field of solid dispersion technology

Taxonomic Diversity of Under storey Vegetation in Kumaun Himalayan Forests

Abstract: Taxonomic diversity of understorey vegetation (herb species) was studied in two evergreen forests, viz. oak and pine in the Kumaun Himalaya. In terms of taxonomic diversity, Asteraceae and Lamiaceae were the two dominant families in the sampling forest types. Maximum number of species was found at hill base and minimum at hill top in both the forests. The number of families, genera and species ratio observed for pine forest was of course higher with compared to the oak forest showed about the higher taxonomic diversity. Perennials form had higher contribution as compared to annuals forms indicated better ability to store up soil. Very few species (9 species) were found to be common indicates higher dissimilarity in both type of forests. Species richness (per m 2 ) was higher in the pine forest than the oak forest. A high value of beta-diversity in the oak forest point out that the species composition varied from one stand to another. However, low concentration of dominance value in the pine forest with compare to the oak forest point towards the dominance, which is shared by many species

Emergence of Lumpy Pox Virus and Their Preventive Measures: A Global Livestock Threat

In the last few years viral disease not only affect the human but also the other life on this planet and result epidemic condition at global level. The highly transmissible viral disease called Lumpy skin disease (LSD) spread in sequential manner at worldwide level affecting the cattle or dairy animals of caprine, ovine and bovine family. The highly mutational efficiency of this viral strains affects the large-scale population and still no effective cure for it. Different vaccines designed at national and international level as a preventive measure to overcome the reoccurrence of this virus e.g., Bovivax-LSD™, Lumpivax™, Poxvac™, Lumpi-ProVacInd. However, still the mortality of LSD are low, not affect humans but emergence of the mutational variants demands novel vaccines

Enhancement and modulation of cosmic noise absorption in the afternoon sector at subauroral location ( L = 5) during the recovery phase of 17 March 2015 geomagnetic storm

The present study has focused on the intense production of cosmic noise absorption (CNA) at Maitri, Antarctica (L = 5; CGM −62°S, 55°E) during the early recovery phase of the largest storm of the current solar cycle commenced on 17 March 2015 St. Patrick's Day. The enhancement of CNA during 15–18 UT (14–17 magnetic local time (MLT); MLT = UT − 1 at Maitri) was as large as the CNA enhancement occurred during the main phase of the storm. During this time the CNA pattern also exhibits oscillation in the Pc5 (2–7 mHz) range and is in simultaneity with geomagnetic pulsations in the same frequency range. We observed the amplitude of CNA pulsation is well correlated with the level of CNA production. High-amplitude Pc5 oscillations were observed in the vicinity of auroral oval near Maitri. Absence of electromagnetic ion cyclotron (EMIC) waves is marked suggesting the possible role of VLF waves in precipitation. The reason for the intense CNA production is found to be the precipitation caused mainly by hiss-driven subrelativistic electrons. The CNA enhancement event is located well inside the dusk plasmaspheric bulge region as suggested by Tsurutani et al. (2015). Signature of enhanced eastward electrojet at Maitri during 14–17 MLT could be an additional factor for such large CNA. In order to establish the cause and effect relationship between the geomagnetic and CNA oscillations at Maitri, transfer entropy method has been used, which confirmed the modulation of CNA by geomagnetic pulsations

Effectiveness of breast crawl method on selected new born and maternal outcomes

The world health Organization (WHO) and UNICEF recommend initiation of breastfeeding within the first hour after birth.1 The deaths of 8,23,000 children and 20,000 mothers each year could be saved by promoting Universal breastfeeding, along with the economic savings of US $ 300 billion.2 The present study was undertaken with the aim to assess the effectiveness of breast crawl method on selected new-born and maternal outcomes at govt. hospital, Dehradun, Uttrakhand. A Quantitative Approach with a quasi-experimental design using non-probability convenient sampling was used. The results depict that at the p< 0.001l level, the breast crawl method had a significant favorable impact on Newborn Temperature at 1 hour, time of placental expulsion, episiotomy pain perception, and involution of uterine II PPD. There was a statistically significant difference in newborn and maternal outcomes between the experimental and control groups at the p<0.001level. The study concluded that Breast crawl was found to be an efficient approach for maintaining effective body temperature, shortening the duration of placental expulsion, reducing episiotomy pain perception, and assisting in early uterine involution