Terminal guidance system

A terminal guidance system is described including a heading command subsystem and a glide-slope command subsystem which develop command signals for use in guiding an aircraft or other vehicle into a preselected heading and/or altitude at a terminal point. The heading command subsystem is responsive to certain input data and continuously develops command signals for use in directing the aircraft from a remote location to a terminal point so that upon arrival it has a preselected terminal heading. The glide-slope command subsystem is responsive to certain other input data and continuously develops command signals for use in controlling the rate of descent of the aircraft so that it will have a preselected altitude and glide-slope upon arrival at the terminal

Passenger ride quality response to an airborne simulator environment

The present study was done aboard a special aircraft able to effect translations through the center of gravity with a minimum of pitch and roll. The aircraft was driven through controlled motions by an on-board analog computer. The input signal was selectively filtered Gaussian noise whose power spectra approximated that of natural turbulence. This input, combined with the maneuvering capabilities of this aircraft, resulted in an extremely realistic simulation of turbulent flight. The test flights also included varying bank angles during turns. Subjects were chosen from among NASA Flight Research Center personnel. They were all volunteers, were given physical examinations, and were queried about their attitudes toward flying before final selection. In profile, they were representative of the general flying public. Data from this study include (1) a basis for comparison with previous commercial flights, that is, motion dominated by vertical acceleration, (2) extension to motion dominated by lateral acceleration, and (3) evaluation of various bank angles

Sprayable birefringent coating enables strain measurements on large surfaces

Birefringent coating for strain measurements on large surfaces contains constituents that can be premixed and sprayed as a single component with conventional paint spray equipment. Elevated temperatures are not required for spraying or curing of the coating material which has long pot life

Realising the therapeutic potential of neuroactive steroid modulators of the GABA_A receptor

In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR). These reports were followed by the discovery that such steroids may be synthesised not only in peripheral endocrine glands, but locally in the central nervous system (CNS), to potentially act as paracrine, or autocrine "neurosteroid" messengers, thereby fine tuning neuronal inhibition. These discoveries triggered enthusiasm to elucidate the physiological role of such neurosteroids and explore whether their levels may be perturbed in particular psychiatric and neurological disorders. In preclinical studies the GABAAR-active steroids were shown to exhibit anxiolytic, anticonvulsant, analgesic and sedative properties and at relatively high doses to induce a state of general anaesthesia. Collectively, these findings encouraged efforts to investigate the therapeutic potential of neurosteroids and related synthetic analogues. However, following over 30 years of investigation, realising their possible medical potential has proved challenging. The recent FDA approval for the natural neurosteroid allopregnanolone (brexanolone) to treat postpartum depression (PPD) should trigger renewed enthusiasm for neurosteroid research. Here we focus on the influence of neuroactive steroids on GABA-ergic signalling and on the challenges faced in developing such steroids as anaesthetics, sedatives, analgesics, anticonvulsants, antidepressants and as treatments for neurodegenerative disorders

Development of systems and techniques for landing an aircraft using onboard television

A flight program was conducted to develop a landing technique with which a pilot could consistently and safely land a remotely piloted research vehicle (RPRV) without outside visual reference except through television. Otherwise, instrumentation was standard. Such factors as the selection of video parameters, the pilot's understanding of the television presentation, the pilot's ground cockpit environment, and the operational procedures for landing were considered. About 30 landings were necessary for a pilot to become sufficiently familiar and competent with the test aircraft to make powered approaches and landings with outside visual references only through television. When steep approaches and landings were made by remote control, the pilot's workload was extremely high. The test aircraft was used as a simulator for the F-15 RPRV, and as such was considered to be essential to the success of landing the F-15 RPRV

Development of optical data processing techniques applicable to detection and study of meteor trails

Development of coherent optical data processing techniques applicable to detection of meteor trails and examination of propertie

Flight test evaluation of a separate surface attitude command control system on a Beech 99 airplane

A joint NASA/university/industry program was conducted to flight evaluate a potentially low cost separate surface implementation of attitude command in a Beech 99 airplane. Saturation of the separate surfaces was the primary cause of many problems during development. Six experienced professional pilots who made simulated instrument flight evaluations experienced improvements in airplane handling qualities in the presence of turbulence and a reduction in pilot workload. For ride quality, quantitative data show that the attitude command control system results in all cases of airplane motion being removed from the uncomfortable ride region

Birefringent coatings for nondestructive testing of honeycomb sandwich structures Final engineering report no. 8379, 30 Jun. 1965 - 15 Mar. 1966

Epoxy birefringent coatings for nondestructive testing of honeycomb sandwich structure