52 research outputs found
Effectiveness of Training Programs for People in Late Adulthood in the Food Services Industry
Occupational and Adult Educatio
SNAI1 expression and the mesenchymal phenotype: an immunohistochemical study performed on 46 cases of oral squamous cell carcinoma
Abstract
Background
SNAI1 can initiate epithelial-mesenchymal transition (EMT), leading to loss of epithelial characteristics and, in cancer, to invasion and metastasis. We hypothesized that SNAI1 reactivation occurs in oral squamous cell carcinoma (OSCC) where it might also be associated with focal adhesion kinase (FAK) expression and p63 loss.
Methods
Immunohistochemistry was performed on 46 tumors and 26 corresponding lymph node metastases. Full tissue sections were examined to account for rare and focal expression. Clinical outcome data were collected and analyzed.
Results
SNAI1-positivity (nuclear, ≥ 5% tumor cells) was observed in 10 tumors and 5 metastases (n = 12 patients). Individual SNAI1(+) tumor cells were seen in primary tumors of 30 patients. High level SNAI1 expression (>10% tumor cells) was rare, but significantly associated with poor outcome. Two cases displayed a sarcomatoid component as part of the primary tumor with SNAI1(+)/FAK(+)/E-cadherin(-)/p63(-) phenotype, but disparate phenotypes in corresponding metastases. All cases had variable SNAI1(+) stroma. A mesenchymal-like immunoprofile in primary tumors characterized by E-cadherin loss (n = 29, 63%) or high cytoplasmic FAK expression (n = 10, 22%) was associated with N(+) status and tumor recurrence/new primary, respectively.
Conclusions
SNAI1 is expressed, although at low levels, in a substantial proportion of OSCC. High levels of SNAI1 may herald a poor prognosis and circumscribed SNAI1 expression can indicate the presence of a sarcomatoid component. Absence of p63 in this context does not exclude squamous tumor origin. Additional EMT inducers may contribute to a mesenchymal-like phenotype and OSCC progression
Mobilities of Knowledge: An Introduction
Mobilities of Knowledge examines how geographical mobility of people and (im)material things has impacted epistemic systems of knowledge in different historical and geographical contexts. In this chapter, the authors introduce concepts and debates in interdisciplinary research on spatial mobility and the production, dissemination, and transfer of knowledge. They suggest extending Urry’s (2007) typology of interdependent mobilities that constitute the space of flows and the space of places (Castells, 1996) from five to six dimensions through the consideration of mobile knowledges, concepts, and practices. Finally, they outline how the chapters of this volume help to identify generic as well as context-specific practices and processes of knowledge production, dissemination, and transfer and call for more empirical case studies to further the collective development of flexible conceptual understandings
Correction: “The 5th edition of The World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms” Leukemia. 2022 Jul;36(7):1720–1748
The role of Guanxi in buyer-supplier relationships in Chinese small and medium-sized enterprises – a resource based perspective
This paper examines the role of guanxi (personal relationships or connections) in buyersupplier
relationships in Chinese small and medium-sized enterprises (SMEs), through exploratory
research that gained access to companies actually using guanxi. The resource-based
view (RBV) provided a systematic approach for analysing the role of guanxi in terms of its
potential to be a source of sustained competitive advantage.
Business guanxi connections were identified as possessing the potential to be considered
an organisational resource. This study identified several valuable attributes of guanxi at
the organisational level. However, the guanxi-based advantage can only be sustained under
certain conditions. SMEs should create an organisational environment that encourages their
employees to actively establish and maintain guanxi connections within the company and
beyond. However, companies in China need to recognise that firms that possess superior
technological skills or capabilities have a stronger bargaining power, as they are able to deliver
quality at competitive prices over the long run
Fine-needle aspiration biopsy versus core-needle biopsy in diagnosing lung cancer: a systematic review
Changes in breast tumour receptor status with time: A prospective study assessing the impact of obtaining confirmatory biopsy at metastatic recurrence on patient management
Contemporary results of percutaneous biopsy of 100 small renal masses: a single centre experience
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