Distributed Environment for Efficient Virtual Machine Image Management in Federated Cloud Architectures

The use of Virtual Machines (VM) in Cloud computing provides various benefits in the overall software engineering lifecycle. These include efficient elasticity mechanisms resulting in higher resource utilization and lower operational costs. VM as software artifacts are created using provider-specific templates, called VM images (VMI), and are stored in proprietary or public repositories for further use. However, some technology specific choices can limit the interoperability among various Cloud providers and bundle the VMIs with nonessential or redundant software packages, leading to increased storage size, prolonged VMI delivery, stagnant VMI instantiation and ultimately vendor lock-in. To address these challenges, we present a set of novel functionalities and design approaches for efficient operation of distributed VMI repositories, specifically tailored for enabling: (i) simplified creation of lightweight and size optimized VMIs tuned for specific application requirements; (ii) multi-objective VMI repository optimization; and (iii) efficient reasoning mechanism to help optimizing complex VMI operations. The evaluation results confirm that the presented approaches can enable VMI size reduction by up to 55%, while trimming the image creation time by 66%. Furthermore, the repository optimization algorithms, can reduce the VMI delivery time by up to 51% and cut down the storage expenses by 3%. Moreover, by implementing replication strategies, the optimization algorithms can increase the system reliability by 74%

The effects of low-calorie sweeteners on energy intake and body weight: a systematic review and meta-analyses of sustained intervention studies.

Previous meta-analyses of intervention studies have come to different conclusions about effects of consumption of low-calorie sweeteners (LCS) on body weight. The present review included 60 articles reporting 88 parallel-groups and cross-over studies ≥1 week in duration that reported either body weight (BW), BMI and/or energy intake (EI) outcomes. Studies were analysed according to whether they compared (1) LCS with sugar, (2) LCS with water or nothing, or (3) LCS capsules with placebo capsules. Results showed an effect in favour of LCS vs sugar for BW (29 parallel-groups studies, 2267 participants: BW change, -1.06 kg, 95% CI -1.50 to -0.62, I2 = 51%), BMI and EI. Effect on BW change increased with 'dose' of sugar replaced by LCS, whereas there were no differences in study outcome as a function of duration of the intervention or participant blinding. Overall, results showed no difference in effects of LCS vs water/nothing for BW (11 parallel-groups studies, 1068 participants: BW change, 0.10 kg, 95% CI -0.87 to 1.07, I2 = 82%), BMI and EI; and inconsistent effects for LCS consumed in capsules (BW change: -0.28 kg, 95% CI -0.80 to 0.25, I2 = 0%; BMI change: 0.20 kg/m2, 95% CI 0.04 to 0.36, I2 = 0%). Occurrence of adverse events was not affected by the consumption of LCS. The studies available did not permit robust analysis of effects by LCS type. In summary, outcomes were not clearly affected when the treatments differed in sweetness, nor when LCS were consumed in capsules without tasting; however, when treatments differed in energy value (LCS vs sugar), there were consistent effects in favour of LCS. The evidence from human intervention studies supports the use of LCS in weight management, constrained primarily by the amount of added sugar that LCS can displace in the diet