Integrated Supply Chain Strategy with Standardization of Professional Communication as Lean Manufacturing Tool

Abstract-The article substantiates the importance of professional communication standardization and supply chain strategy as lean manufacturing tool, which is loss reduction reserve in the organizations of different fields. They consider the issues of organization effectiveness impact in the field of communication processes, and the effectiveness of its work in general. They provided the definition of professional communication standardization process, the main conditions for its occurrence are highlighted. The formation of lean communication is proposed as the result of professional communication standardization. They summarized the advantages of standardized professional communication gained by the company

Developing supply chain management and lean environment for improving the company performance

The article discusses the ways to improve the efficiency of enterprises and organizations in a constantly changing and competitive environment. They analyzed the approaches to the definition of "lean production". Based on the analysis and comparison of approaches to the definition of “innovation environment” notion, the author suggests the approach of the “lean environment” development in the regio

Prognostic criteria of paracentetic - drainage method effectiveness for treatment of extra-organ infected fluid collection in abdominal cavity

Introduction: One of the most important current surgical tasks is the treatment of the intraabdominal abscess patients, because there is neither positive tendency to reduce the amount of acute inflammatory diseases of abdominal cavity organs nor the tendency to reduce the postoperative suppurative complications. There is no doubt today about efficiency of transcutaneous abscess drainage under ultrasound guidance, but there are some contradictory opinions about efficiency of paracentetic treatment as compared to conventional surgical procedure. Research goal is to study the effectiveness criteria of paracentetic-drainage method in extra-organ infected fluid intraabdominal collections treatment and their dependence on collection echostructure and etiology. Material and methods: The retrospective analysis was carried out on 53 medical case-histories of extraorgan intra-abdominal abscess patients treated in surgical department of Regional clinical hospital No 1 in Kemerovo. The ultrasonic data, such as size, wall structure and characteristics of content were analyzed. The patients were divided into two groups: the 1st group (37 patients, n=37) consisted of patients who underwent only abscess paracentesis or drainage under ultrasound guidance; the 2nd group consisted of patients (n=16) who underwent open abscess drainage after inefficient paracentetic-drainage. Results: the etiology analyses of intraabdominal collections showed the paracentetic-drainage approach to be more often efficient for surgery on hepatobiliary system of patients with fluid collections in subhepatic area (42%). The most frequent cause for fluid formations in the 2nd group patients was acute pancreatitis, pancreatonecrosis - 45.3%. The volume of fluid collection in the 1st group patients was significantly less (74.4±0.3 ml) than in the 2nd patients group (117.8±2.3 ml). The formation echostructure analyze of both groups showed the 1st group to have formations with well-defined shapes (x2 = 2.55; p=0.01) and smaller size (x2 = 5.71; p=0.017). Heterogeneous echostructure and infiltrated fluid collections around were characteristically to the 2nd group patients. The analysis also showed that infected fluid collections containing pus in the 1st patients group were smaller in volume than in the 2nd group (73.84±0.3 ml to 111.75±0.5 ml respectively). According to the leukocyte index of intoxication (LII) analysis there is no reliable difference between LII in the 1st and the 2nd groups (p-29). But it is certain that LII reduces on the 3rd day after the drainage (the 1st group patients from 1.9 to 1.3; the 2nd group patients from 4.6 to 1.45). Conclusion: The efficiency of transcutaneous paracentesis under ultrasound guidance depends on etiology and echostructure of intraabdominal abscess. In case of pancreatic necrosis the minimal invasive method has an insignificant effect as the final treatment stage because of sequesters

Anatomical and physiological basis of the reduced occlusion syndrome

Decrease in the interalveolar distance (IAD) that develops during a period of permanent occlusion as a result of progressive primary dental diseases: Increased abrasion of hard tissues of the teeth, extensive edentulous space, and generalized form of periodontitis is accompanied by morphofunctional changes in the masticatory muscles and the development of temporomandibular joint dysfunction. The objective of the study was to identify development mechanisms of the reduced occlusion syndrome that develops as a result of decrease in the IAD caused by primary dental disease

Selection and synthesis of general mechanisms for formation of CHF in comorbid pathology

The work analyses the pathogenesis of chronic heart failure (CHF) with preserved ejection fraction (EF); General mechanisms of CHF formation in concomitant diseases are outlined; Modern data on the effect of co morbid pathology on cardiac remodelling and dysfunction in patients with chronic heart failure with a preserved EF are summarize

РАСШИРЕНИЕ ВОЗМОЖНОСТЕЙ ВАКЦИНОПРОФИЛАКТИКИ ПАПИЛЛОМАВИРУСНОЙ (ВПЧ)-ИНФЕКЦИИ: ЗАЩИТА ОТ ЦЕЛОГО СПЕКТРА ВПЧ-АССОЦИИРОВАННЫХ ЗАБОЛЕВАНИЙ ЛИЦ РАЗЛИЧНОГО ВОЗРАСТА И ПОЛА

HPV is the most widespread sexually transmitted infection. HPV affects men and women regardless of age and leads to the development of various anogenital area diseases. International studies proved a wide clinical range of the tetravalent HPV vaccine protection and allowed recommending it for the prevention of not only cervical cancer, but also of vulvar, vaginal and anal cancer and anogenital condylomae in patients of both sexes. 42 countries have already introduced national HPV-vaccination programs in compliance with WHO recommendations. Anogenital area cancer morbidity reduction in these countries is expected in 10-15 years. However, a reduction or even complete disappearance of anogenital condylomae among the population has already been noted in a range of countries because the incubation period of this disease is short; this is the first marker of vaccination efficacy in a population.ВПЧ — самая распространенная инфекция, передаваемая половым путем. ВПЧ поражает мужчин и женщин независимо от возраста и приводит к развитию различных заболеваний аногенитальной области. Проведенные международные клинические исследования подтвердили широкий спектр защиты четырехвалентной вакцины против ВПЧ и позволили рекомендовать ее для профилактики не только рака шейки матки, но и рака вульвы, влагалища, анального канала и аногенитальных кондилом у лиц обоих полов. 42 страны уже внедрили национальные программы ВПЧ-вакцинации в соответствии с рекомендациями ВОЗ. Снижение заболеваемости раком аногенитальной области в этих странах ожидается через 10–15 лет. Однако уже сейчас в ряде стран отмечается снижение или даже полное исчезновение аногенитальных кондилом среди населения, что связано с коротким инкубационным периодом данного заболевания и является первым маркером эффективности вакцинации в популяции

Immuno oriented therapy for mandible fractures in patients at high risk of developing inflammatory complications

Comparative clinical and immunological analysis of treatment of 49 patients with fractures of the mandible, receiving traditional therapy and treatment with use of immumomodulator leukinferon is carried out in this work. The results of the study demonstrate, that use of immunocorrection with leukinferon gives high immunological effect in comparison with traditional patients treatment. Positive dynamics of immunological parameters changes at patients is closely correlates with current of a clinical state in posttraumatic period. Use of leukinferon in complex therapy at patients with fracture of the mandible with high risk of inflammatory complications development allows to improve a condition of patients in shorter period and to warn inflammatory complications development

Investigation on the association of cardiovascular markers with severity of chronic pyelonephritis

Chronic kidney disease (CKD) is an established independent risk factor for cardiovascular disease (CVD) and is caused by chronic pyelonephritis (CP). This study aimed to investigate the effect of the association of cardiovascular markers with the course of CP on the comorbidity of CP with ischemic heart disease. The study participants included 125 patients with CP without symptoms of urinary tract obstruction who were divided into three group

Comparative evaluation of chitosan-based multifunctional wound dressings: a multistage randomised controlled experimental trial

Background. Wounds of various aetiology are among the most frequent traumatic injuries. A prospective route to improve treatment of this nosology is the development of novel or advancement of the already on-stage dressing materials.Objectives. A comparative experimental assay of novel chitosan-based wound dressings in the healing of soft tissue wounds of different genesis using ultrasound to control biodegradation of the developed dosage form.Methods. Soft tissue wounds were modelled in experimental animals, conventional and lineage male rats, 275 (± 25) g body weight, and male rabbits, 2,900 (± 150) g weight, using a proprietary methodology (Patent on invention RU No. 2703709 dated 23 August, 2018).Two wound dressing samples selected as most promising and applicable in large-volume soft tissue aseptic wounds were tested in the final step of experiment. Ultrasound imaging of the model wound area during the sample material biodegradation was used to control the wound process in more detail. At all steps of experiment, animal models were handled in compliance with GOST 33044-2014 “Principles of Good Laboratory Practice”.Histomorphological assays were carried out with common protocols. Variation statistics was used for the data analysis, including the mean (M) and standard mean error (± m) estimation. The level of statistical significance was p < 0.05.Results. The animal assays and comprehensive evaluation of the obtained data revealed a high healing efficacy of chitosan-based wound coatings. The analyses of wound dressing samples have confirmed their predesigned properties: scaffold stability, capillarity, biodegradability and matrix capacities for the carried drug delivery.Additionally, ultrasound was proved effective to estimate dynamics of the coated wound healing and biopolymer biodegradation processes.Conclusion. The developed chitosan-based wound dressings exhibited efficacy in an experimental model of the soft tissues wound process.The use of ultrasound to study dynamics of the wound process and coating biodegradation provided an adequate congruence between the imaging and tissue histomorphology data, as well as the structure and properties of coating material

ВАКЦИНАЦИЯ ПОДРОСТКОВ В ЕВРОПЕЙСКОМ РЕГИОНЕ. СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ

This article describes the peculiarities of the National immunization programs for adolescents in the WHO Euro region. A comparative analysis of the groups was conducted based on economic development. The best and the worst performing states were identified in every group. It was demonstrated that economic development is not the leading factor that determines a country’s vaccination policy. В статье описаны особенности национальных программ вакцинации подростков стран Европейского региона Всемирной организации здравоохранения,  и в зависимости от уровня развития экономики выполнен сравнительный анализ по группам лидирующих и отстающих стран. Показано, что экономический фактор не является ведущим в определении политики вакцинации в стране и расширения национального календаря прививок