The Pulsed Spectra of Two Extraordinary Pulsars

We report on X-ray monitoring of two isolated pulsars within the same RXTE field of view. PSR J1811-1925 in the young supernova remnant G11.2-0.3 has a nearly sinusoidal pulse profile with a hard pulsed spectrum (photon index \~1.2). The pulsar is a highly efficient (~ 1% of spin-down energy) emitter of 2-50 keV pulsed X-rays despite having a fairly typical B ~ 2e12 G magnetic field. PSR J1809-1943/XTE J1810-197 is a newly discovered slow (P=5.54 s), apparently isolated X-ray pulsar which increased in flux by a factor of ~100 in 2003 January. Nine months of monitoring observations have shown a decrease in pulsed flux of ~ 30% without a significant change in its apparently thermal spectrum (kT ~0.7 keV) or pulse profile. During this time, the spin-down torque has fluctuated by a factor of ~ 2. Both the torque and the flux have remained steady for the last 3 months, at levels consistent with a magnetar interpretation.Comment: 3 pages, 4 figures, to appear in the Proceedings of X-ray Timing 2003: Rossi and Beyond, ed. P. Kaaret, F.K. Lamb, & J.H. Swank held in Cambridge, MA, Nov. 3-5, 200

Three-dimensional neurite tracing under globally varying contrast

We study the 3D neurite tracing problem in different imaging modalities. We consider that the examined images do not provide sufficient contrast between neurite and background, and the signal-to-noise ratio varies spatially. We first split the stack into box sub-volumes, and inside each box we evolve simultaneously a number of different open-curve snakes. The curves deform based on three criteria: local image statistics, local shape smoothness, and a term that enforces pairwise attraction between snakes, given their spatial proximity and shapes. We validate our method using larva Drosophila sensory neurons imaged with confocal laser scanning microscopy, as well as publicly available datasets

Long term hard X-ray variability of the anomalous X-ray pulsar 1RXS J170849.0-400910 discovered with INTEGRAL

We report on a multi-band high-energy observing campaign aimed at studying the long term spectral variability of the Anomalous X-ray Pulsar (AXP) 1RXS J170849.0-400910, one of the magnetar candidates. We observed 1RXS J170849.0-400910 in Fall 2006 and Spring 2007 simultaneously with Swift/XRT, in the 0.1-10 keV energy range, and with INTEGRAL/IBIS, in the 20-200 keV energy range. Furthermore, we also reanalyzed, using the latest calibration and software, all the publicly available INTEGRAL data since 2002, and the soft X-ray data starting from 1999 taken using BeppoSAX, Chandra, XMM, and Swift/XRT, in order to study the soft and hard X-ray spectral variability of 1RXS J170849.0-400910. We find a long-term variability of the hard X-ray flux, extending the hardness-intensity correlation proposed for this source over 2 orders of magnitude in energy.Comment: 5 pages, 2 figures, accepted for publication in Astronomy & Astrophysics main journa

Comparison and optimisation of microRNA extraction from the plasma of healthy pregnant women

Circulating microRNA (miRNA) biomarkers are implicated in the diagnosis, monitoring and prediction of various disease processes. Before embarking upon biomarker discovery, miRNA extraction techniques must first be optimised in the biofluid and population under study. Using plasma from a healthy pregnant woman, it was attempted to optimise and compare the performance of two commercially available miRNA extraction kits; Qiagen (miRNeasy Serum/Plasma) and Promega (Maxwell® RSC miRNA from Tissue or Plasma or Serum). Sample miRNA content (concentration and percentage) was assessed using Agilent Bioanalyzer Small RNA chips and reverse transcription‑quantitative PCR (RT‑qPCR) using four constitutively expressed miRNAs (hsa‑miR‑222‑3p, hsa‑let‑7i‑3p, hsa‑miR‑148‑3p and hsa‑miR‑30e‑5p). Quality control spike‑ins monitored RNA extraction (UniSp2, 4 and 5) and cDNA synthesis (UniSp6, cel‑miR‑39‑3p) efficiency. Optimisation approaches included: i) Starting volume of plasma; the addition of ii) Proteinase K; iii) a RNA bacteriophage carrier (MS2); and iv) a glycogen carrier. The two kits exhibited equivalence in terms of miRNA recovery based on Bioanalyzer and RT‑qPCR ΔΔCq results. Optimisation attempts for both kits failed to improve upon miRNA content compared with standard methodology. Comparing the standard methodology, the Qiagen kit was more consistent (smaller variance of ΔCq values) compared with the Promega kit. The standard methodology of either kit would be suitable for the investigation of miRNA biomarkers in a healthy pregnant population

Magnetar-like X-ray Bursts from an Anomalous X-ray Pulsar

Anomalous X-ray Pulsars (AXPs) are a class of rare X-ray pulsars whose energy source has been perplexing for some 20 years. Unlike other, better understood X-ray pulsars, AXPs cannot be powered by rotation or by accretion from a binary companion, hence the designation ``anomalous.'' AXP rotational and radiative properties are strikingly similar to those of another class of exotic objects, the Soft Gamma Repeaters (SGRs). However, the defining property of SGRs, namely their low-energy gamma-ray and X-ray bursts, have heretofore not been seen in AXPs. SGRs are thought to be ``magnetars,'' young neutron stars powered by the decay of an ultra-high magnetic field. The suggestion that AXPs are magnetars has been controversial. Here we report the discovery, from the direction of AXP 1E 1048-5937, of two X-ray bursts that have many properties similar to those of SGR bursts. These events imply a close relationship between AXPs and SGRs, with both being magnetars.Comment: 14 pages, 2 figures, accepted for publication in Nature. Note: The content of this paper is embargoed until 1900 hrs London time / 1400 US Eastern Time on Sept 1

Influence of the photon - neutrino processes on magnetar cooling

The photon-neutrino processes $\gamma e^{\pm} \to e^{\pm} \nu \bar \nu$, $\gamma \to \nu \bar \nu$ and $\gamma \gamma \to \nu \bar \nu$ are investigated in the presence of a strongly magnetized and dense electron-positron plasma. The amplitudes of the reactions $\gamma e^{\pm} \to e^{\pm} \nu \bar \nu$ and $\gamma \gamma \to \nu \bar \nu$ are obtained. In the case of a cold degenerate plasma contributions of the considering processes to neutrino emissivity are calculated. It is shown that contribution of the process $\gamma \gamma \to \nu \bar \nu$ to neutrino emissivity is supressed in comparision with the contributions of the processes $\gamma e^{\pm} \to e^{\pm} \nu \bar \nu$ and $\gamma \to \nu \bar \nu$. The constraint on the magnetic field strength in the magnetar outer crust is obtained.Comment: 8 pages, LaTeX, 2 PS figures, based on the talk presented by D.A. Rumyantsev at the XV International Seminar Quarks'2008, Sergiev Posad, Moscow Region, May 23-29, 2008, to appear in the Proceeding

Near-infrared follow-up to the May 2008 activation of SGR 1627-41

On 28 May 2008, the Swift satellite detected the first reactivation of SGR 1627-41 since its discovery in 1998. Following this event we began an observing campaign in near infrared wavelengths to search for a possible counterpart inside the error circle of this SGR, which is expected to show flaring activity simultaneous to the high energy flares or at least some variability as compared to the quiescent state. For the follow-up we used the 0.6m REM robotic telescope at La Silla Observatory, which allowed a fast response within 24 hours and, through director discretionary time, the 8.2m Very Large Telescope at Paranal Observatory. There, we observed with NACO to produce high angular resolution imaging with the aid of adaptive optics. These observations represent the fastest near infrared observations after an activation of this SGR and the deepest and highest spatial resolution observations of the Chandra error circle. 5 sources are detected in the immediate vicinity of the most precise X-ray localisation of this source. For 4 of them we do not detect variability, although the X-ray counterpart experimented a significant decay during our observation period. The 5th source is only detected in one epoch, where we have the best image quality, so no variability constrains can be imposed and remains as the only plausible counterpart. We can impose a limit of Ks > 21.6 magnitudes to any other counterpart candidate one week after the onset of the activity. Our adaptive optics imaging, with a resolution of 0.2" provides a reference frame for subsequent studies of future periods of activity.Comment: Accepted for publication in A&

Evidence for a Binary Companion to the Central Compact Object 1E 1207.4-5209

Unique among neutron stars, 1E 1207.4-5209 is an X-ray pulsar with a spin period of 424 ms that contains at least two strong absorption features in its energy spectrum. This neutron star has been identified as a member of the radio-quiet compact central objects in supernova remnants. It has been found that 1E 1207.4-5209 is not spinning down monotonically suggesting that this neutron star undergoes strong, frequent glitches, contains a fall-back disk, or possess a binary companion. Here, we report on a sequence of seven XMM-Newton observations of 1E 1207.4-5209 performed during a 40 day window in June/July 2005. Due to unanticipated variance in the phase measurements beyond the statistical uncertainties, we could not identify a unique phase-coherent timing solution. The three most probable timing solutions give frequency time derivatives of +0.9, -2.6, and +1.6 X 10^(-12) Hz/s (listed in descending order of significance). We conclude that the local frequency derivative during our XMM-Newton observing campaign differs from the long-term spin-down rate by more than an order of magnitude, effectively ruling out glitch models for 1E 1207.4-5209. If the long-term spin frequency variations are caused by timing noise, the strength of the timing noise in 1E 1207.4-5209 is much stronger than in other pulsars with similar period derivatives. Therefore, it is highly unlikely that the spin variations are caused by the same physical process that causes timing noise in other isolated pulsars. The most plausible scenario for the observed spin irregularities is the presence of a binary companion to 1E 1207.4-5209. We identified a family of orbital solutions that are consistent with our phase-connected timing solution, archival frequency measurements, and constraints on the companions mass imposed by deep IR and optical observations.Comment: 8 pages, 4 figures. To be published in the proceedings of "Isolated Neutron Stars: from the Interior to the Surface" (April 24-28, 2006) - eds. D. Page, R. Turolla & S. Zan