5,394 research outputs found
Impact of the Nanoscale Organization of Nitroxyl Mixed Self-Assembled Monolayers on their Electrocatalytic Behaviour
Electrocatalysis: The molecular distribution of redox centers on mixed nitroxyl SAMs strongly influences the electrocatalytic reactivity
Dynamical Mean Field Theory of the Antiferromagnetic Metal to Antiferromagnetic Insulator Transition
We study the antiferromagnetic metal to antiferromagnetic insulator using
dynamical mean field theory and exact diagonalization methods. We find two
qualitatively different behaviors depending on the degree of magnetic
correlations. For strong correlations combined with magnetic frustration, the
transition can be described in terms of a renormalized slater theory, with a
continuous gap closure driven by the magnetism but strongly renormalized by
correlations. For weak magnetic correlations, the transition is weakly first
order.Comment: 4 pages, uses epsfig,4 figures,notational errors rectifie
MIPS: The Multiband Imaging Photometer for SIRTF
The Multiband Imaging Photometer for SIRTF (MIPS) is to be designed to reach as closely as possible the fundamental sensitivity and angular resolution limits for SIRTF over the 3 to 700μm spectral region. It will use high performance photoconductive detectors from 3 to 200μm with integrating JFET amplifiers. From 200 to 700μm, the MIPS will use a bolometer cooled by an adiabatic demagnetization refrigerator. Over much of its operating range, the MIPS will make possible observations at and beyond the conventional Rayleigh diffraction limit of angular resolution
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents
Targeted approaches aiming at modulating NHERF1 activity, rather than its overall expression, would be preferred to preserve the normal functions of this versatile protein. We focused our attention on the NHERF1/PDZ1 domain that governs its membrane recruitment/displacement through a transient phosphorylation switch. We herein report the design and synthesis of novel NHERF1 PDZ1 domain inhibitors. These compounds have potential therapeutic value when used in combination with antagonists of β-catenin to augment apoptotic death of colorectal cancer cells refractory to currently available Wnt/β-catenin-targeted agents
Induction in a von Karman flow driven by ferromagnetic impellers
We study magnetohydrodynamics in a von K\'arm\'an flow driven by the rotation
of impellers made of material with varying electrical conductivity and magnetic
permeability. Gallium is the working fluid and magnetic Reynolds numbers of
order unity are achieved. We find that specific induction effects arise when
the impeller's electric and magnetic characteristics differ from that of the
fluid. Implications in regards to the VKS dynamo are discussed.Comment: 14 pages, 7 figure
TRPM6 is essential for magnesium uptake and epithelial cell function in the colon
Intestinal magnesium (Mg) uptake is essential for systemic Mg homeostasis. Colon cells express the two highly homologous transient receptor potential melastatin type (TRPM) 6 and 7 Mg2+ channels, but their precise function and the consequences of their mutual interaction are not clear. To explore the functional role of TRPM6 and TRPM7 in the colon, we used human colon cell lines that innately express both channels and analyzed the functional consequences of genetic knocking-down, by RNA interference, or pharmacological inhibition, by NS8593, of either channel. TRPM7 silencing caused an increase in Mg2+ influx, and correspondingly enhanced cell proliferation and migration, while downregulation of TRPM6 did not affect significantly either Mg2+ influx or cell proliferation. Exposure to the specific TRPM6/7 inhibitor NS8593 reduced Mg2+ influx, and consequently cell proliferation and migration, but Mg supplementation rescued the inhibition. We propose a model whereby in colon cells the functional Mg2+ channel at the plasma membrane may consist of both TRPM7 homomers and TRPM6/7 heteromers. A different expression ratio between the two proteins may result in different functional properties. Altogether, our findings confirm that TRPM6 cannot be replaced by TRPM7, and that TRPM6/7 complexes and TRPM6/7-mediated Mg2+ influx are indispensable in human epithelial colon cells
AVHRR and VISSR satellite instrument calibration results for both Cirrus and marine stratocumulus IFO periods
Accurate characterizations of some cloud parameters are dependent upon the absolute accuracy of satellite radiance measurements. Visible wavelength measurements from both the AVHRR and VISSR instruments are often used to study cloud characteristics. Both of these instruments were radiometrically calibrated prior to launch, but neither has an onboard device to monitor degradation after launch. During the FIRE/SRB cirrus Intensive Field Operation (IFO), a special effort was made to monitor calibration of these two instruments onboard the NOAA-9 and GOES-6 spacecraft. In addition, several research groups have combined their efforts to assess the long-term performance of both instruments. These results are presented, and a limited comparison is made with the ERBE calibration standard
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