Dark Energy Nature in Logarithmic f(R,T)f(R,T) Cosmology

The present research paper is an investigation of dark energy nature of logarithmic $f(R, T)$-gravity cosmology in a flat FLRW space-time universe. We have derived modified Einstein's field equations for the function $f(R, T)=R-16\pi G\alpha\ln(T)$ where $R$ is the Ricci scalar curvature, $T$ is the trace of the stress energy momentum tensor and $\alpha$ is a model parameter. We have solved field equations in the form of two fluid scenario as perfect-fluid and dark-fluid, where dark fluid term is derived in the form of perfect fluid source. We have made an observational constraints on the cosmological parameters $\Omega_{(m)}, \omega^{(de)}$ and $H_{0}$ using $\chi^{2}$ test with observational datasets like Pantheon sample of SNe Ia and $H(z)$. With these constraints we have discussed our model with deceleration parameter $q$, energy parameters $\Omega_{(m)}, \Omega_{(de)}$, EoS parameter $\omega^{(de)}$ etc. Also, we have done Om diagnostic analysis. The derived $f(R, T)$ model shows a quintessence dark energy model $\omega^{(de)}>-1$ and late-time universe approaches to $\Lambda$CDM model.Comment: 16 pages, 8 figure

Physics Potential of the ICAL detector at the India-based Neutrino Observatory (INO)

The upcoming 50 kt magnetized iron calorimeter (ICAL) detector at the India-based Neutrino Observatory (INO) is designed to study the atmospheric neutrinos and antineutrinos separately over a wide range of energies and path lengths. The primary focus of this experiment is to explore the Earth matter effects by observing the energy and zenith angle dependence of the atmospheric neutrinos in the multi-GeV range. This study will be crucial to address some of the outstanding issues in neutrino oscillation physics, including the fundamental issue of neutrino mass hierarchy. In this document, we present the physics potential of the detector as obtained from realistic detector simulations. We describe the simulation framework, the neutrino interactions in the detector, and the expected response of the detector to particles traversing it. The ICAL detector can determine the energy and direction of the muons to a high precision, and in addition, its sensitivity to multi-GeV hadrons increases its physics reach substantially. Its charge identification capability, and hence its ability to distinguish neutrinos from antineutrinos, makes it an efficient detector for determining the neutrino mass hierarchy. In this report, we outline the analyses carried out for the determination of neutrino mass hierarchy and precision measurements of atmospheric neutrino mixing parameters at ICAL, and give the expected physics reach of the detector with 10 years of runtime. We also explore the potential of ICAL for probing new physics scenarios like CPT violation and the presence of magnetic monopoles.Comment: 139 pages, Physics White Paper of the ICAL (INO) Collaboration, Contents identical with the version published in Pramana - J. Physic

DNA structure(s) recognized and bound by large subunit of Replication Factor C (ls RFC) in Drosophila melanogaster

Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references.Issued also on microfiche from Lange Micrographics.Alternative (non-B type) DNA structures are thought to be formed as intermediates in developmentally important mechanisms such as DNA replication, DNA repair, and genetic recombination. It is proposed that these alternative DNA structure(s) and the proteins that recognize them may play an important role in the regulation of cellular mechanisms. There has been an enhancement in the knowledge of proteins that bind to the DNA by recognizing specific sequence and/or structural aspects of the DNA. lsRFC (large subunit Replication Factor C) is a protein that binds to the DNA in a sequence independent manner and recognizes structural determinant(s) in the DNA structure. lsRFC is an essential part of the five subunit RFC complex involved in the process of eukaryotic DNA replication. RFC complex loads PCNA and DNA polymerase delta onto the replication template during replication and is required both for leading and lagging strand synthesis. Southwestern analyses using synthetic oligonucleotides containing internal complementary sequences to form DNA structures reveal that structural determinants present in the branched DNA structures are most strongly bound by lsRFC. Osmium tetroxide chemical modification of these synthetic DNA structures verifies the formation of the predicted branched structures. Tsurimoto and Stillman (I 99 1) used DNase and micrococcal nuclease footprinting assays to define a primer template junction as a substrate for the RFC complex binding. A synthetic primer-template junction is bound by lsRFC in nitrocellulose filter binding (Southwestern) assays; however, it is bound approximately five fold less efficiently than branched DNA structures but better than single stranded DNA or duplex DNA. This suggests that HP96 contains a determinant that is preferentially recognized by lsRFC. To investigate the determinant present, chemical probing using osmium tetroxide was performed and reveals either single strand or distorted duplex nature at the proposed primer template junction. Based on the Southwestern assays and the chemical modification data, it is proposed that lsRFC preferentially recognizes and binds angles or bends in the DNA and may recognize the replication fork formed at the junction between parental and daughter strands. This proposed intimate association of lsRFC with the replication fork may influence the progression of the fork