263 research outputs found
Premiers rĂ©sultats de lâexploration dâun site archĂ©ologique Ă Sillery
Archeological investigation of an Indian site was conducted in 1959 and 1960 by /'Ăquipe d'archĂ©ologie de QuĂ©bec at Sillery, within the limits of Metropolitan QuĂ©bec. From written sources as well as from numerous documents found in situ, it appears that this site was the scĂšne of much activity through the centuries. Artifacts were found, but no pottery, and this tends to suggest archaic occupation of a workshop-site. Most of the finds are attributed to the Montagnais, the Abenaquis, the Hurons and some other tribes. The dating of the material is uneasy for there is evidence of the removing of local topsoil and rocks for dock filling and house building purposes in the surroundings
Hulbert, François (1989) Essai de gĂ©opolitique urbaine et rĂ©gionale. La comĂ©die urbaine de QuĂ©bec. MontrĂ©al, Ăditions du MĂ©ridien, 474 p.
An American Ambulance Driver in France during the Great War The Lasting Memory and Relationship between Harry N. Deyo, the Men of Section 591, and French Civilians
This thesis presents the experiences of Harry N. Deyo, a graduate of the University of Michigan, who volunteered to serve in the United States Army Ambulance Service in France during the Great War. The friendship between Deyo and the drivers of Section 591 lasted throughout his lifetime. These friendships were important to his life; they were a way to share common bonds and to remember the war in the context of camaraderie and affection between themselves and the French civilians who cared for them. The role of rural French civilians and the relationships formed with the American ambulance drivers is also explored. Studies of collective memory and remembrance evidence the bond shared among these distinctive groups of people. This thesis argues that the relationships between the men of Section 591 and the French civilians they encountered were unique experiences and had lasting effects long after the end of the war
An American Ambulance Driver in France during the Great War: The Lasting Memory and Relationship between Harry N. Deyo, the Men of Section 591, and French Civilians
This thesis presents the experiences of Harry N. Deyo, a graduate of the University of Michigan, who volunteered to serve in the United States Army Ambulance Service in France during the Great War. The friendship between Deyo and the drivers of Section 591 lasted throughout his lifetime. These friendships were important to his life; they were a way to share common bonds and to remember the war in the context of camaraderie and affection between themselves and the French civilians who cared for them. The role of rural French civilians and the relationships formed with the American ambulance drivers is also explored. Studies of collective memory and remembrance evidence the bond shared among these distinctive groups of people. This thesis argues that the relationships between the men of Section 591 and the French civilians they encountered were unique experiences and had lasting effects long after the end of the war
The Sun, The Moon, and The Truth
The Sun, The Moon, and The Truth is a collection of two plays: North Wind and I Lived To Tell. Both plays explore the human condition through differing lenses.
In North Wind, a play deeply rooted in magical realism, a trio of characters search for freedom from the past in a snow-bound Midwestern bar. The dramatic question of North Wind is: How do you move forward when everything you see reminds you of what youâve lost?
I Lived To Tell, a non-linear play, takes place in the character\u27s imagination. The play\u27s dramatic question is: How does a person maintain their identity in the wake of a cancer diagnosis?
An Afterward looks at the playwright\u27s journey of becoming a playwright and the creative process of both plays
La reprise aux Ătats-Unis : Ă qui profitent les bas taux d'intĂ©rĂȘts?
Ce travail cherche aÌ comprendre deux choses : dâune part, si la politique moneÌtaire ultra- accommodante de la banque centrale ameÌricaine depuis la crise de 2007 est davantage une reÌponse aux difficulteÌs de Wall Street ou de Main Street et dâautre part, si les retombeÌes beÌneÌficient davantage aÌ Wall Street ou aÌ Main Street. Pour arriver aÌ ces fins, nous eÌtudions l'eÌvolution du lien entre la politique moneÌtaire et deux facteurs, soient la santeÌ des marcheÌs boursiers et celle de l'eÌconomie ameÌricaine
Caractérisation d'un effecteur de phosphoinositides chez le parasite de la malaria Plasmodium falciparum
La malaria est une maladie infectieuse causant plus de 500 000 morts chaque annĂ©e. La maladie est causĂ©e par un protozoaire de la famille Plasmodium. Lâapparition de souches rĂ©sistantes aux traitements actuels et lâabsence de vaccin efficace rendent la dĂ©couverte de nouvelles cibles thĂ©rapeutiques urgente. Le parasite possĂšde un complexe apical, un groupement de vacuoles sĂ©crĂ©toires spĂ©cialisĂ©es contenant les protĂ©ines responsables de lâinvasion du globule rouge. Nous nous intĂ©ressons aux mĂ©canismes gouvernant le transport intracellulaire de ces protĂ©ines et Ă la biogenĂšse du complexe apical lors de la formation des nouveaux parasites. Plus particuliĂšrement, nous nous intĂ©ressons au rĂŽle des phosphoinositides dans le recrutement des protĂ©ines Ă la membrane de lâappareil de Golgi. Par analyse bio-informatique du gĂ©nome de P. falciparum, nous avons identifiĂ© plusieurs protĂ©ines effectrices liant potentiellement les phosphoinositides. Les travaux prĂ©sentĂ©s dans ce mĂ©moire concernent Mal13P1.188, une protĂ©ine possĂ©dant un domaine Pleckstrin homology. Nous proposons que Mal13P1.188 ait un rĂŽle dans la gĂ©nĂ©ration du complexe apical en recrutant les protĂ©ines le constituant Ă la membrane du Golgi par la liaison avec les phosphoinositides. Afin de vĂ©rifier nos hypothĂšses, nous avons gĂ©nĂ©rĂ© une lignĂ©e de parasite dont le gĂšne de Mal13P1.188 est fusionnĂ© avec une GFP et une hĂ©magglutinine. Ă lâaide de cette lignĂ©e de parasite, nous avons pu identifier Mal13P1.188 Ă proximitĂ© de lâappareil de Golgi lorsque les parasites Ă©taient sous la forme schizont du cycle Ă©rythrocytaire. Dâautres expĂ©riences ont permis de confirmer que le domaine Pleckstrin homology de Mal13P1.188 Ă©tait capable de reconnaĂźtre les diffĂ©rentes formes de phosphoinositides. Finalement, dâautres travaux devront ĂȘtre faits sur Mal13P1.188 afin de dĂ©terminer si elle est essentielle Ă la survie du parasite.Malaria is a deadly infectious disease taking more than 500,000 lives each year. The disease is caused by a protozoan of the Plasmodium family. Resistant strains beginning to spread and the inexistence of an efficient vaccine make the discovery of new targets urgent. The parasite secretes proteins to invade the red blood cell. Those proteins are regrouped in the apical complex, a group of organelles used for the invasion. Our research team focus on the transport mechanisms that drive the formation of the apical complex during the cellular division of new parasite. In other terms, we are interested on the role of phosphoinositide in the recruitment of protein inside the Golgi apparatus. After a bioinformatics analyse the P. falciparum genome, we identified many effectors protein that can bind phosphoinositides. Among them, we focused our work on Mal13P1.188, a protein with a Pleckstrin homology domain. We propose that Mal13P1.188 has a role in the recruitment of the apical proteins to the Golgi membrane using phosphoinositide as a marker on the membrane. To verify that hypothesis, we generated a strain of parasite with endogenous Mal13P1.188 tagged to a GFP and a hemagglutinin. With those parasites, we identified Mal13P1.188 near the Golgi apparatus during the Schizont stage of the blood cycle. Other experiment confirmed that the Pleckstrin homology domain of Mal13P1.188 is able to bind different form of phosphoinositides. Finally, more work has to be done to confirm if Mal13P1.188 is essential to the parasite survival
Effet d'une intervention en physiothérapie, intégrant l'exposition graduelle in vivo, sur les peurs d'individus avec une lombalgie subaiguë : une étude pilote
L'Ă©tude prĂ©sentĂ©e dans ce mĂ©moire a comparĂ© les effets, Ă court terme, de l'exposition in vivo jumelĂ©e Ă la physiothĂ©rapie usuelle Ă ceux de la physiothĂ©rapie usuelle seule, sur les peurs de l'activitĂ© physique et du travail et sur le statut fonctionnel chez des individus avec une lombalgie subaiguĂ«. Cette Ă©tude pilote a utilisĂ© un devis quasi-expĂ©rimental avec groupe contrĂŽle non Ă©quivalent. Seize sujets ont participĂ© Ă l'Ă©tude. Les mesures de rĂ©sultat ont Ă©tĂ© effectuĂ©es avec l'Ăchelle de kinĂ©siophobie de Tampa, le Fear-Avoidance Beliefs Questionnaire et le Roland-Morris Disability Questionnaire. Les groupes Ă©taient comparables Ă l'Ă©valuation initiale. Ă l'Ă©valuation finale, l'exposition in vivo jumelĂ©e Ă la physiothĂ©rapie usuelle contribuait mieux Ă rĂ©duire les peurs de l'activitĂ© physique et du travail et Ă amĂ©liorer le statut fonctionnel que la physiothĂ©rapie usuelle seule. Cette Ă©tude pilote supporte la pertinence de rĂ©aliser des Ă©tudes avec des devis expĂ©rimentaux comportant des Ă©chantillons plus grands
Le rĂŽle des hormones sexuelles dans la perception de la douleur chez le rat
Il est fréquemment observé en clinique que les femmes sont plus susceptibles de vivre une douleur récurrente, des niveaux de douleur plus sévÚres et de la douleur de plus longue durée, que les hommes (UNRUH, 1996). Cependant, certaines évidences nous permettent de croire que les hormones sexuelles ont un important rÎle à jouer dans ces différences de perception et de modulation de la douleur entre les hommes et les femmes. Afin de vérifier ce rÎle potentiel des hormones sexuelles sur la douleur, nous avons effectué différents tests chez des rats Sprague-Dawley (1) mùles, (2) femelles, (3) castrés et (4) ovariectomisés. Deux tests de douleur thermique ( hot plate et cold plate ) et un test chimique (le test à la formaline) ont été utilisés comme modÚles de douleur aiguë et de douleur chronique, respectivement. De plus, un test d'inhibition de la douleur induite par le stress (le swim test ) a été fait afin de vérifier un mécanisme de modulation de la douleur. Finalement, des analyses immunchistochimiques ont été faites afin de corréler ces comportements et les niveaux de neurotransmetteurs impliqués dans les mécanismes de perception et de modulation de la nociception."--Résumé abrégé par UM
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