Ready, Set, Network! Research Speed Networking for Clinicians, Scientists and Engineers

Objectives: A 2013 Institute of Medicine report urged researchers to “engage in additional substantive and productive collaborations” to address important clinical/translational science questions. To encourage team science among our researchers, Tompkins-McCaw Library for the Health Sciences and Center for Clinical and Translational Research hosted a speed networking event, specifically targeting engineers, clinicians, and basic scientists; an analysis of the event is below. Methods: Invitations were distributed to clinicians, engineers, and basic scientists. To maximize interactions without increasing time spent at the event, researchers were divided into three groups. The event was planned such that each group would meet everyone from the other two groups; researchers were placed into appropriate groups according to their interests. Seated at tables of three, attendees introduced themselves and discussed their research interests for three minutes; then they rotated according to their group’s instructions. Lunch was provided afterwards to give attendees an opportunity to follow up with potential collaborators. Results: Twenty-one faculty researchers attended the speed networking event, which took about 30 minutes, excluding lunch. Using a 5-point Likert scale, all participants selected “strongly agree” or “agree” to respond to questions about whether the event was a valuable use of their time. Also, 53% of attendees “strongly” agreed with the statement “I met a potential collaborator” at the event. Discussion: Subjective evaluations show that researchers see speed networking as an effective way to meet potential collaborators. Objective data including sustained research partnerships and collaborative grant and publication submissions will be tracked

Health Sciences Collection Development: An Overview of Fundamental Knowledge and Practices (2nd Edition)

This Open Access work from the Medical Library Association Collection Development Caucus provides an overview of the responsibilities and tasks involved in the development and management of health sciences collections. Readers can explore topics in greater detail through references at the end of each chapter. You can access the most up-to-date version of this work at https://doi.org/10.21974/1tsq-na6

Short Courses: Flexible Learning Opportunities in Informatics

In today’s fast-paced, data-driven world, researchers need to have a good foundation in informatics to store, organize, process, and analyze growing amounts of data. However, not all degree programs offer such training. Obtaining training in informatics on your own can be a daunting task for both new and established researchers who have little informatics experience. Providing educational opportunities appropriate for various skill levels and that mesh with a full-time schedule can remove barriers and foster a collaborative, informatics-savvy community that is better equipped to push science forward. To enhance informatics education in bioinformatics, VCUs Wright Center for Clinical and Translational Research of- fers a complementary series of seminars and workshops. These short course offerings introduce attendees to bioinformatics concepts and applications, and provide hands-on experience using online Bioinformatics databases. Bioinformatics 101 (B101) is an 8-week long series of 1-hour seminars focused on introducing topics in bioinformatics related to Next Generation Sequencing (NGS). Lectures are application focused and include overviews of NGS technology, practical bioinformatics pipelines, and examples of how the technology can influence downstream bioinformatics analyses. Bioinformatics 102 (B102) is a 5-day, 2 hours per day workshop developed in collaboration with VCU Libraries that provides attendees with hands-on experience accessing and using public data repositories. Sessions include a brief lecture followed by hands-on exercises. A Certificate of Completion is awarded upon meeting certain criteria for either the 101 or 102 courses. Bioinformatics 101 has been offered 3 times with a combined total of 246 registrants, and Bioinformatics 102 has been offered twice with a total of 78 registrants (limited to 30 per session per day). From course surveys, 82% (n=108) and 95% (n=47) of respondents gave B101 and B102 a positive rating, respectively. In addition, 89% of B101 respondents indicated their knowledge was improved, with 100% of B102 respondents indicating the same. A total of 84 and 33 certificates have been awarded for B101 and B102, respectively. The Bioinformatics 101 and 102 courses have become highly anticipated across the university, and have gained the external attention of surrounding businesses and colleges. Registrants have diverse backgrounds including biological, clinical, computational, administrative, librarian, business, and others with a total of 77 departments across VCU and VCU Health represented. Due to this interest, Bioinformatics 101 began offering live online attendance to accommodate those who were unable to travel across campus, or who are attending from outside VCU. This past year, 50% of attendance was online indicating a growing need for flexible education opportunities in informatics. Increasing researcher knowledge of Bioinformatics along with awareness of university resources for informatics support fosters an informatics-savvy research community that is empowered to take advantage of existing and new data sources in the pursuit of new insights and scientific discoveries for the betterment of human health. Future work will include the development of a more comprehensive educational framework by creating new and flexible learning opportunities that will make informatics education easy and convenient for our dedicated researchers

Providing Support for an Interdisciplinary Research Group with a Multidisciplinary Informationist Team: Is It Effective?

Background Three subject librarians and a data librarian, representing three departments and two libraries at a university, were awarded an NLM Informationist Supplement to support an interdisciplinary Research Group with an NIH grant. The Informationist Team developed a model to utilize the skills of multiple librarians to support the increasing number of interdisciplinary and interprofessional research groups at the university. Librarians routinely attended lab meetings and shared notes with each other to monitor researcher needs. Methods The Informationist Team regularly provided support for literature searches, creating search alerts, bibliographic citation management and sharing, and data management to an interdisciplinary Research Group over a two year period. Two new library workshops were also developed after observing researcher needs. Surveys were administered to the Research Group prior to, during, and after a two-year period to assess the effectiveness of an Informationist Team model that employs the skills of multiple librarians. Results Surveys administered to the Research Group showed that the group increased their use of appropriate resources to find scientific and technical information over a two-year period. Additionally, by the final survey, all members of the Research Group had worked with a librarian and all felt it had saved them time. The data librarian also facilitated the creation of a form to collect data for a lab protocol that helped the group avoid significant errors. Conclusions The relationship between the multidisciplinary Informationist Team and the Research Group was mutually beneficial. The Research Group was able to improve its knowledge and efficiency with the Informationist Team’s assistance, and regular librarian attendance at lab meetings enabled librarians to enhance their understanding of basic science research. Having a multidisciplinary team of librarians allowed for sharing the workload and for deeper assistance to the Research Group in specialized areas such as data management

Providing Hands-on Training with Bioinformatics Databases: A Collaboration Between VCU Libraries & Wright Center for Clinical and Translational Research

BackgroundWith the goal of increasing specialized services for researchers, Virginia Commonwealth University (VCU) Libraries sent its basic science librarians to an intensive training on bioinformatics databases, “A Librarian’s Guide to NCBI.” VCU’s Wright Center for Clinical and Translational Research (Wright CCTR) was expanding the educational component of its bioinformatics support around the same time. This year, the librarians partnered with the Wright CCTR to offer an introductory bioinformatics database workshop introducing researchers to genetic/genomic databases. MethodsFor one week in June, sessions were conducted introducing up to 30 faculty and staff to The Cancer Genome Atlas and NCBI’s Gene, BLAST, Variation Viewer and Gene Expression Omnibus. Librarians taught resources they learned in the NCBI training, and Wright CCTR staff taught resources they use often. Each day’s 1.5 hour session included presentations, demonstrations, and hands-on assignment time. Certificates were awarded to participants who completed 4 out of 5 assignments. ResultsRegistration for the workshop was full in under a week with a waiting list. All survey respondents (n=27) evaluated the overall quality of the workshop as good or excellent and indicated that they would recommend the workshop to a colleague or student. ConclusionsThis successful partnership between VCU Libraries and the Wright CCTR allowed for a broader range of bioinformatics topics to be covered, in addition to easing the planning and teaching workload for each group. The strong interest in this series across a variety of disciplines from both VCU and VCU Health indicates a need for staff and faculty-oriented bioinformatics training within the university

Collaborating to Improve Collaboration: Informationist Team Support for an Interdisciplinary Research Group

Objectives Three subject librarians and a data librarian, representing three departments and two libraries at a university, were awarded an NLM Informationist Supplement to support an interdisciplinary research group with an NIH grant. The Informationist Team developed a model to utilize the skills of multiple librarians to support the increasing number of interdisciplinary and interprofessional research groups at the university. Methods A pre-survey was administered to the Research Group to provide a baseline assessment of their use of librarian expertise and library services. The Informationist Team met to identify areas of expertise to support the objectives of the grant. Literature searching, bibliographic citation management and sharing, and data management were the first areas to be considered. Librarians routinely attended lab meetings and shared notes with each other to keep up with researcher needs. When possible, research questions were answered in the lab meetings by librarians. Interviews with Research Group members were used to develop a data management plan. Collaborative tools to facilitate team communication and support research being conducted in multiple buildings on two campuses were investigated. Future work will include publication support, assessing research impact, and appraising the usefulness of the Informationist Team to the Research Group

Kajian keratan rentas mengenai masalah perlakuan di kalangan remaja di Jerijeh, Belawai, Sarawak : faktor-faktor risiko dan persepsi ibubapa

cross sectional study on the prevalence of behavioural problems, the risk factors and perception of parents towards adolescent aged 13 - 19 years old in Kampung Jerijeh was done from 4 September-20 October 2000 by Year 4 Medical Students of Faculty of Medicine and Health Sciences) UNIMAS. 108 parents and 78 teenage respondents were studied using universal sample technique. 24 respondent had to be excludeds, as they could not be found for interview after three trials. This study was done by questionnaire cum interview technique. Two different sets of questionnaire were used for the adolescent respondent and parent respondent. Results of the study shows that 24.9% of respondent have taken alcohol before, 2.6% had sniffed glue, 33.3% had smoked and 52.6% had disciplinary problems. This study shows a statistically significant association between age and attitude with disciplinary problems. There are no significant association between knowledge of respondents with disciplinary problem. There are also no significant association between knowledge and attitude of respondents with disciplinary problems, alcohol abuse, smoking and glue sniffing. More male adolescent respondents had behavioural problems compared to their female counterparts. Some factors for these behavioural problems were identified as boredom, curiosity to try something different and peer influence. The majority of the parent respondents were not aware of behavioural problems in their children. An intervention program with the theme of `Remaja Berwawasan Tunggak Negara' was held from 24 September -8 October 2000 with the objective to increase the attitude and to increase the knowledge of adolescents regarding behavioural problems

Regulation of mTORC1 Signaling by pH

BACKGROUND: Acidification of the cytoplasm and the extracellular environment is associated with many physiological and pathological conditions, such as intense exercise, hypoxia and tumourigenesis. Acidification affects important cellular functions including protein synthesis, growth, and proliferation. Many of these vital functions are controlled by mTORC1, a master regulator protein kinase that is activated by various growth-stimulating signals and inactivated by starvation conditions. Whether mTORC1 can also respond to changes in extracellular or cytoplasmic pH and play a role in limiting anabolic processes in acidic conditions is not known. METHODOLOGY/FINDINGS: We examined the effects of acidifying the extracellular medium from pH 7.4 to 6.4 on human breast carcinoma MCF-7 cells and immortalized mouse embryo fibroblasts. Decreasing the extracellular pH caused intracellular acidification and rapid, graded and reversible inhibition of mTORC1, assessed by measuring the phosphorylation of the mTORC1 substrate S6K. Fibroblasts deleted of the tuberous sclerosis complex TSC2 gene, a major negative regulator of mTORC1, were unable to inhibit mTORC1 in acidic extracellular conditions, showing that the TSC1-TSC2 complex is required for this response. Examination of the major upstream pathways converging on the TSC1-TSC2 complex showed that Akt signaling was unaffected by pH but that the Raf/MEK/ERK pathway was inhibited. Inhibition of MEK with drugs caused only modest mTORC1 inhibition, implying that other unidentified pathways also play major roles. CONCLUSIONS: This study reveals a novel role for the TSC1/TSC2 complex and mTORC1 in sensing variations in ambient pH. As a common feature of low tissue perfusion, low glucose availability and high energy expenditure, acidic pH may serve as a signal for mTORC1 to downregulate energy-consuming anabolic processes such as protein synthesis as an adaptive response to metabolically stressful conditions

Partnering with postdocs: A library model for supporting postdoctoral researchers and educating the academic research community

Initially conceived by the University of Pittsburgh Health Sciences Library System in 2013, How-to Talks by Postdocs is a series of instructional brown-bag lunch talks presented by postdocs about how to do something related to the health sciences. These are not seminar talks, but an opportunity for postdocs to hone their science communication skills by informing the public about a topic related to the health sciences. VCU launched its How-to Talks by Postdocs series in 2015. The quantitative data collected from attendees and postdoc speakers from its 2015-2018 talks are being shared here. The attendee feedback can be downloaded from the main Download link, while the postdoc feedback can be downloaded as a supplemental material

Comparing Square-Planar Rh^I and Ir^I: Metal–Ligand Proton Tautomerism, Fluxionality, and Reactivity

A series of low-valent square-planar Rh complexes [LHRh][X] (X = PF6, Br, Cl, I) bearing two protic imidazolyl phosphines (one κ2) and a CO ligand were synthesized and fully characterized. A comparison of the CO stretching frequencies with those of the previously reported [LHIr][X] complexes indicates a much lower electron density at the Rh centers. This lower electron density at Rh results in a lower propensity to undergo ligand to metal proton transfer, and in contrast to observations with Ir, the [LHRh][X] complexes (X = Cl, Br, I) do not equilibrate with their metal-protonated congeners. Furthermore, the weaker bond strengths of Rh complexes compared to Ir lead to an increased degree of fluxionality in the former, along with a difference in reactivity with hydrogen (H2) and iodine (I2)