Composing protocol frameworks for active wireless networks

This article describes a new model for a composible protocol framework that is suitable for the rapid development of any application-specific service and its deployment in the network. The class-hierarchy model described here enables users to compose their own custom, flexible frameworks from either predefined or custom protocol components tailored to an application's needs. We validate experimentally that application-specific frameworks implementing custom protocols can be developed to improve performance of applications over wireless networks.©2000 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE

Population adaptation for genetic algorithm-based cognitive radios

Abstract — Genetic algorithms are best suited for optimization problems involving large search spaces. The problem space encountered when optimizing the transmission parameters of an agile or cognitive radio for a given wireless environment and set of performance objectives can become prohibitively large due to the high number of parameters and their many possible values. Recent research has demonstrated that genetic algorithms are a viable implementation technique for cognitive radio engines. However, the time required for the genetic algorithms to come to a solution substantionally increases as the system complexity grows. In this paper, we present a population adaptation technique for genetic algorithms that takes advantage of the information from previous cognition cycles in order to reduce the time required to reach an optimal decision. Our simulation results demonstrate that the amount of information from the previous cognition cycle can be determined from the environmental variation factor (EVF), which represents the amount of change in the environment parameters since the previous cognition cycle. I

Design and Architectural Implications of a Spatial Information System

Image analysis, at the higher levels, works with extracted regions and line segments and their properties, not with the original raster data. Thus a spatial information system must be able to store points, lines, and areas as well as their properties and interrelationships. In a previous paper (Shapiro and Haralick [22]), we proposed for this purpose an entity-oriented relational database system. In this paper we describe our first experimental spatial information system, which employs these concepts to store and retrieve watershed data for a portion of the state of Virginia. We describe the logical and physical design of the system and discuss the architectural implications

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.

Acute myeloid leukemia (AML) cells meet the higher energy, metabolic, and signaling demands of the cell by increasing mitochondrial biogenesis and mitochondrial protein translation. Blocking mitochondrial protein synthesis through genetic and chemical approaches kills human AML cells at all stages of development in vitro and in vivo. Tigecycline is an antimicrobial that we found inhibits mitochondrial protein synthesis in AML cells. Therefore, we conducted a phase 1 dose-escalation study of tigecycline administered intravenously daily 5 of 7 days for 2 weeks to patients with AML. A total of 27 adult patients with relapsed and refractory AML were enrolled in this study with 42 cycles being administered over seven dose levels (50-350 mg/day). Two patients experienced DLTs related to tigecycline at the 350 mg/day level resulting in a maximal tolerated dose of tigecycline of 300 mg as a once daily infusion. Pharmacokinetic experiments showed that tigecycline had a markedly shorter half-life in these patients than reported for noncancer patients. No significant pharmacodynamic changes or clinical responses were observed. Thus, we have defined the safety of once daily tigecycline in patients with refractory AML. Future studies should focus on schedules of the drug that permit more sustained target inhibition

Measurements and Analysis of Secondary User Device Effects on Digital Television Receivers

This is the published version. Copyright © 2009 Newman et al.This article presents results from a study of the potential effects of secondary users operating in unoccupied television spectrum. Television spectrum is known within the wireless communications community as being underutilized, making it a prime candidate for dynamic spectrum access. The proposed use of this open spectrum has prompted questions concerning the quantity of available channel space that could be used without negative impact on consumers who view digital television broadcasts and the viability of secondary use of open channels immediately adjacent to a digital television broadcast channel. In this work, we investigate secondary device operation in the channels directly adjacent to a desired television channel, and the effects upon a selection of consumer digital television (DTV) receivers. Our observations strongly suggest that secondary users could operate "White Space Devices" (WSDs) in unoccupied channel bandwidth directly adjacent to a desired digital television (DTV) channel, with no observable adverse impact upon the reception of the desired channel content

An open system transportation security sensor network: field trial experiences

Abstract Cargo shipments are subject to hijack, theft, or tampering. Furthermore, cargo shipments are at risk of being used to transport contraband, potentially resulting in fines to shippers. The Transportation Security Sensor Network (TSSN), which is based on open software systems and Service Oriented Architecture (SOA) principles, has been developed to mitigate these risks. Using commercial off-the-shelf (COTS) hardware, the TSSN is able to detect events and report those relevant to appropriate decision makers. However, field testing is required to validate the system architecture as well as to determine if the system can provide timely event notification. Field experiments were conducted to assess the TSSN's suitability for monitoring rail-borne cargo. Log files were collected from these experiments and postprocessed. We present the TSSN architecture and results of field experiments, including the time taken to report events using the TSSN as well as on the interaction between various components of the TSSN. These results show that the TSSN architecture can be used to monitor rail-borne cargo. i

The Rapidly Deployable Radio Network

The Rapidly Deployable Radio Network (RDRN) is an architecture and experimental system to develop and evaluate hardware and software components suitable for implementing mobile, rapidly deployable, and adaptive wireless communications systems. The driving application for the RDRN is the need to quickly establish a communications infrastructure following a natural disaster, during a law enforcement activity, or rapid deployment of military force. The RDRN project incorporates digitally controlled antenna beams, programmable radios, adaptive protocols at the link layer, and mobile node management. This paper describes the architecture for the Rapidly Deployable Radio Network and a prototype system built to evaluate key system components

Active Networking Services for Wired/Wireless Networks

An active networking architecture provides the infrastructure for applications to inject user programs into the nodes of the network. This enables customization of the network nodes so that application-specific services can be downloaded into the network in the form of new protocols. In this pape