190 research outputs found
Testing the Impact of Group Offending on Behavioural Similarity in Serial Robbery
Behavioural case linkage assumes that offenders behave in a similar way across their crimes. However, group offending could impact on behavioural similarity. This study uses robbery data from two police forces to test this by comparing the behavioural similarity of pairs of lone offences (LL), pairs of group offences (GG) and pairs of offences where one crime was committed alone and the other in a group (GL). Behavioural similarity was measured using Jaccard’s coefficients. Kruskal–Wallis tests were used to examine differences between the three categories within the linked samples. No statistically significant differences were found for linked GG compared to linked LL pairs. However, differences emerged between GL and the other categories for some behaviours (especially control) suggesting caution should be applied when linking group and lone offences committed by the same perpetrator. Differences between linked and unlinked pairs were assessed using receiver operating characteristic. The results suggest it is possible to distinguish between linked and unlinked pairs based on behaviour especially within the GG and LL categories. There were, however, fewer significant findings for the GL sample, suggesting there may be issues linking crimes where the offender commits one crime as part of a group and the other alone
Cataclysmic Variables from SDSS II. The Second Year
The first full year of operation following the commissioning year of the
Sloan Digital Sky Survey has revealed a wide variety of newly discovered
cataclysmic variables. We show the SDSS spectra of forty-two cataclysmic
variables observed in 2002, of which thirty-five are new classifications, four
are known dwarf novae (CT Hya, RZ Leo, T Leo and BZ UMa), one is a known CV
identified from a previous quasar survey (Aqr1) and two are known ROSAT or
FIRST discovered CVs (RX J09445+0357, FIRST J102347.6+003841). The SDSS
positions, colors and spectra of all forty-two systems are presented. In
addition, the results of follow-up studies of several of these objects identify
the orbital periods, velocity curves and polarization that provide the system
geometry and accretion properties. While most of the SDSS discovered systems
are faint (>18th mag) with low accretion rates (as implied from their spectral
characteristics), there are also a few bright objects which may have escaped
previous surveys due to changes in the mass transfer rate.Comment: Accepted for publication in The Astronomical Journal, Vol. 126, Sep.
2003, 44 pages, 25 figures (now with adjacent captions), AASTeX v5.
Calibrating CHIME, A New Radio Interferometer to Probe Dark Energy
The Canadian Hydrogen Intensity Mapping Experiment (CHIME) is a transit
interferometer currently being built at the Dominion Radio Astrophysical
Observatory (DRAO) in Penticton, BC, Canada. We will use CHIME to map neutral
hydrogen in the frequency range 400 -- 800\,MHz over half of the sky, producing
a measurement of baryon acoustic oscillations (BAO) at redshifts between 0.8 --
2.5 to probe dark energy. We have deployed a pathfinder version of CHIME that
will yield constraints on the BAO power spectrum and provide a test-bed for our
calibration scheme. I will discuss the CHIME calibration requirements and
describe instrumentation we are developing to meet these requirements
Canadian Hydrogen Intensity Mapping Experiment (CHIME) Pathfinder
A pathfinder version of CHIME (the Canadian Hydrogen Intensity Mapping
Experiment) is currently being commissioned at the Dominion Radio Astrophysical
Observatory (DRAO) in Penticton, BC. The instrument is a hybrid cylindrical
interferometer designed to measure the large scale neutral hydrogen power
spectrum across the redshift range 0.8 to 2.5. The power spectrum will be used
to measure the baryon acoustic oscillation (BAO) scale across this poorly
probed redshift range where dark energy becomes a significant contributor to
the evolution of the Universe. The instrument revives the cylinder design in
radio astronomy with a wide field survey as a primary goal. Modern low-noise
amplifiers and digital processing remove the necessity for the analog
beamforming that characterized previous designs. The Pathfinder consists of two
cylinders 37\,m long by 20\,m wide oriented north-south for a total collecting
area of 1,500 square meters. The cylinders are stationary with no moving parts,
and form a transit instrument with an instantaneous field of view of
100\,degrees by 1-2\,degrees. Each CHIME Pathfinder cylinder has a
feedline with 64 dual polarization feeds placed every 30\,cm which
Nyquist sample the north-south sky over much of the frequency band. The signals
from each dual-polarization feed are independently amplified, filtered to
400-800\,MHz, and directly sampled at 800\,MSps using 8 bits. The correlator is
an FX design, where the Fourier transform channelization is performed in FPGAs,
which are interfaced to a set of GPUs that compute the correlation matrix. The
CHIME Pathfinder is a 1/10th scale prototype version of CHIME and is designed
to detect the BAO feature and constrain the distance-redshift relation.Comment: 20 pages, 12 figures. submitted to Proc. SPIE, Astronomical
Telescopes + Instrumentation (2014
An Attempt to Determine the Largest Scale of Primordial Density Perturbations in the Universe
Inflationary cosmology predicts that the particle horizon should be
generically much bigger than the present-day Hubble radius, . This
implies a special regime of super-Hubble scale energy density fluctuations
imprinted on the cosmic microwave background radiation (CMBR), which from
present theory could only be explained by inflation Causality constraints are
used to determine models for the power spectrum that accommodate a suppression
scale. A three parameter likelihood analysis is performed of the COBE-DMR
4-year data with respect to the amplitude, spectral index, and suppression
scale. It is found that all suppression length scales larger than are
consistent with the data, but that scales of order are slightly
preferred, at roughly the one-sigma level. Many non-inflation models would be
consistent with a small suppression length scale, whereas for standard
inflation models, the duration of the inflation epoch would have to be bounded
by a fairly small upper limit. Suppression scales smaller than are
strongly excluded by the anisotrophy data.Comment: 9 pages, Latex, 1 figure, additional tests reporte
Limits on the ultra-bright Fast Radio Burst population from the CHIME Pathfinder
We present results from a new incoherent-beam Fast Radio Burst (FRB) search
on the Canadian Hydrogen Intensity Mapping Experiment (CHIME) Pathfinder. Its
large instantaneous field of view (FoV) and relative thermal insensitivity
allow us to probe the ultra-bright tail of the FRB distribution, and to test a
recent claim that this distribution's slope, , is quite small. A 256-input incoherent beamformer was
deployed on the CHIME Pathfinder for this purpose. If the FRB distribution were
described by a single power-law with , we would expect an FRB
detection every few days, making this the fastest survey on sky at present. We
collected 1268 hours of data, amounting to one of the largest exposures of any
FRB survey, with over 2.4\,\,10\,deg\,hrs. Having seen no
bursts, we have constrained the rate of extremely bright events to
\,sky\,day above \,220 Jy\,ms
for between 1.3 and 100\,ms, at 400--800\,MHz. The non-detection also
allows us to rule out with 95 confidence, after
marginalizing over uncertainties in the GBT rate at 700--900\,MHz, though we
show that for a cosmological population and a large dynamic range in flux
density, is brightness-dependent. Since FRBs now extend to large
enough distances that non-Euclidean effects are significant, there is still
expected to be a dearth of faint events and relative excess of bright events.
Nevertheless we have constrained the allowed number of ultra-intense FRBs.
While this does not have significant implications for deeper, large-FoV surveys
like full CHIME and APERTIF, it does have important consequences for other
wide-field, small dish experiments
A Small Conductance Calcium-Activated K<sup>+</sup> Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying
In the nervous system of mice, small conductance calcium-activated potassium (SK) channels function to regulate neuronal excitability through the generation of a component of the medium afterhyperpolarization that follows action potentials. In humans, irregular action potential firing frequency underlies diseases such as ataxia, epilepsy, schizophrenia and Parkinson's disease. Due to the complexity of studying protein function in the mammalian nervous system, we sought to characterize an SK channel homologue, KCNL-2, in C. elegans, a genetically tractable system in which the lineage of individual neurons was mapped from their early developmental stages. Sequence analysis of the KCNL-2 protein reveals that the six transmembrane domains, the potassium-selective pore and the calmodulin binding domain are highly conserved with the mammalian homologues. We used widefield and confocal fluorescent imaging to show that a fusion construct of KCNL-2 with GFP in transgenic lines is expressed in the nervous system of C. elegans. We also show that a KCNL-2 null strain, kcnl-2(tm1885), demonstrates a mild egg-laying defective phenotype, a phenotype that is rescued in a KCNL-2-dependent manner. Conversely, we show that transgenic lines that overexpress KCNL-2 demonstrate a hyperactive egg-laying phenotype. In this study, we show that the vulva of transgenic hermaphrodites is highly innervated by neuronal processes and by the VC4 and VC5 neurons that express GFP-tagged KCNL-2. We propose that KCNL-2 functions in the nervous system of C. elegans to regulate the rate of egg-laying. © 2013 Chotoo et al
Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization
Islet transplantation is an efficacious therapy for type 1 diabetes; however, islets from multiple donor pancreata are required, and a gradual attrition in transplant function is seen. Here, we manufactured human umbilical cord perivascular mesenchymal stromal cells (HUCPVCs) to Good Manufacturing Practice (GMP) standards. HUCPVCs showed a stable phenotype while undergoing rapid ex vivo expansion at passage 2 (p2) to passage 4 (p4) and produced proregenerative factors, strongly suppressing T cell responses in the resting state and in response to inflammation. Transplanting an islet equivalent (IEQ):HUCPVC ratio of 1:30 under the kidney capsule in diabetic NSG mice demonstrated the fastest return to normoglycemia by 3 days after transplant: Superior glycemic control was seen at both early (2.7 weeks) and later stages (7, 12, and 16 weeks) versus ratios of 1:0, 1:10, and 1:50, respectively. Syngeneic islet transplantation in immunocompetent mice using the clinically relevant hepatic portal route with a marginal islet mass showed that mice transplanted with an IEQ:HUCPVC ratio of 1:150 had superior glycemic control versus ratios of 1:0, 1:90, and 1:210 up to 6 weeks after transplant. Immunodeficient mice transplanted with human islets (IEQ:HUCPVC ratio of 1:150) exhibited better glycemic control for 7 weeks after transplant versus islet transplant alone, and islets transplanted via the hepatic portal vein in an allogeneic mouse model using a curative islet mass demonstrated delayed rejection of islets when cotransplanted with HUCPVCs (IEQ:HUCPVC ratio of 1:150). The immunosuppressive and proregenerative properties of HUCPVCs demonstrated long-term positive effects on graft function in vivo, indicating that they may improve long-term human islet allotransplantation outcomes
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