Israeli Peacemaking Since 1967: Factors Behind the Breakthroughs and Failures, by Galia Golan. Reviewed by Michael Garver

This book review analyzes Galia Golan’s recent book Israeli Peacemaking Since 1967: Factors Behind the Breakthroughs and Failures. Using seven (7) conflicts following the 1967 Seven-day War, Golan identifies the actors and processes that were factors that led to progress or failure in the peacemaking relations between Israel, neighboring Arab nations, and international parties. Leadership, security, and interstate negotiation were the three (3) primary factors that were identified as having the greatest impact on Israeli peacemaking process, both positive and negative. The interplay between primary leaders and leaders of opposing factions (spoilers) is traced through the course of the initiation of conflicts and the peace process to illustrate the importance of regime change and public opinion pressure on Israel and parties negotiating with Israel. The legitimate security concerns of Israel were also analyzed and were criticized in light of changes in the relations between different neighboring parties. Golan also covers the complex impact of the variety of actors and interests that have comprised the interstate negotiations that have supported and sabotaged the peacemaking process in the Middle East. Written from the perspective of an Israeli academic and a private citizen, Golan makes compelling arguments that illustrate the conditions under which the peace process has resulted in breakthroughs and the conditions that have resulted in failure

Time-Clamped, RPE-Matched Treadmill Activity and Interactive Video Game Dancing Differ in Step Count But Not Heart Rate Response

Background: Participation in regular moderate or vigorous physical activity (MVPA) results in numerous health benefits. Task enjoyment is a known antecedent and promoter of regular activity engagement. Participation in interactive video gaming has increased in recent years. Purpose: The aims of the present investigation were to: 1) determine heart rate (HR) and step count outcomes of time-clamped and RPE-matched interactive video game dancing (VGD) and treadmill activity; 2) characterize the suitability of VGD to achieve MVPA designation; and, 3) investigate step count outcomes recorded by pedometry and accelerometry. Methods: Subjects underwent three testing sessions with the latter two randomized. During the familiarization visit, the perceived exertion (Borg RPE) of an interactive VGD activity was determined and a treadmill speed that resulted in an RPE-matched exertion level was identified through incremental increases in treadmill speed. On subsequent visits, subjects completed 15 minutes of VGD or RPE-matched treadmill activity. HR and step count were measured during both sessions. Results: Nine participants (Age 19.8 ± 1.6; 5 males; 4 females) volunteered. With time-clamped and RPE-matched, the average HR for dancing 154.7 (± 21.8) and treadmill activity 157.8 (± 25.1) were not different (p = 0.698). The selected dances for the VGD activity resulted in 8/9 subjects exercising at MVPA intensity according to percent of predicted maximal HR (threshold of 64% maximal HR; equation: 207 – 0.7*Age). Steps completed during dancing and treadmill activity according to pedometry were 1510 (± 488) and 2066 (± 247), respectively, with the difference being significant (p = 0.001). Steps completed during dancing and the treadmill activity according to accelerometry were 988 (± 256) and 1938 (± 119), respectively, with the difference again significant (p \u3c 0.001). The within-mode, between-device step count (pedometer vs. accelerometer, respectively) were also of interest. For dancing, a significant difference (p \u3c 0.001) was noted as 1510 (± 488) vs. 988 (± 256) steps. For treadmill activity, the disparity between 2066 (± 247) vs. 1938 (± 119) was also different (p = 0.042). Discussion: The HR response of a VGD activity was not different than a time-clamped, RPE-matched treadmill activity. Furthermore, VGD achieved designation as MVPA intensity in 8/9 subjects with the lone subject failing to achieve moderate designation by a single beat. Of note, objectively determined step count varied by mode and measuring device illustrating the need to employee prudency when selecting measuring technique for step count during rhythmic vs. non-rhythmic PA

Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol.

A mutation in the gene encoding for the liver mitochondrial aldehyde dehydrogenase (ALDH2-2), present in some Asian populations, lowers or abolishes the activity of this enzyme and results in elevations in blood acetaldehyde upon ethanol consumption, a phenotype that greatly protects against alcohol abuse and alcoholism. We have determined whether the administration of antisense phosphorothioate oligonucleotides (ASOs) can mimic the low-activity ALDH2-2 Asian phenotype. Rat hepatoma cells incubated for 24 h with an antisense oligonucleotide (ASO-9) showed reductions in ALDH2 mRNA levels of 85% and ALDH2 (half-life of 22 h) activity of 55% equivalent to a \u3e90% inhibition in ALDH2 synthesis. Glutamate dehydrogenase mRNA and activity remained unchanged. Base mismatches in the oligonucleotide rendered ASO-9 virtually inactive, confirming an antisense effect. Administration of ASO-9 (20 mg/kg/day for 4 d) to rats resulted in a 50% reduction in liver ALDH2 mRNA, a 40% inhibition in ALDH2 activity, and a fourfold (P \u3c 0.001) increase in circulating plasma acetaldehyde levels after ethanol (1 g/kg) administration. Administration of ASO-9 to rats by osmotic pumps led to an aversion (-61%, P \u3c 0.02) to ethanol. These studies provide a proof of principle that specific inhibition of gene expression can be used to mimic the protective effects afforded by the ALDH2-2 phenotype

Benign Conduction Abnormalities in Response to Acute, Moderately-High, Simulated Altitude Exposure

Acclimatization to altitude can improve endurance performance above levels achieved solely by training at sea level. There is natural limitation in the applicability of employing terrestrial altitude training – namely proximity. A simple, non-cumbersome method of simulating altitude is desirable to many types of endurance athletes. The Alto2Lab (Pharma Pacific Inc.), consisting of primarily a breathing tube and silo stack, has shown some potential in this role. There is a lack of evidence regarding whether simulated altitude exposure triggers abnormal cardiovascular responses. The aim of this study was to provide initial evidence of cardiac changes associated with usage patterns that follow distributor guidelines. Twenty-five participants (mean age 29 ± 10.7; 16 males; 9 females) volunteered for the study. Subjects underwent a baseline ECG recording followed by ECG recording during sham (4-5 mins), hypoxia (~6 mins), and recovery (3-4 mins) phases. The sham phase consisted of subjects breathing normoxive air through a foam-filled silo system. The sham stack mimicked the look and feel of the silo system used to produce hypoxia with the difference being a single, soda lime-filled silo. A recovery phase followed hypoxia. Pulse oximetry (SpO2) was used to assess oxygen saturation. Cochran’s Q was employed to test the frequencies of responses across the phases. An independent, blinded, experienced clinician (DK) analyzed the recordings. Two subjects were removed from the final analysis (inability to finish the protocol, baseline right bundle branch block). All subjects demonstrated an increase in heart rate (mean = +16.8 ± 8.0) during the hypoxia (mean oxygen saturation = 82 ± 4.1%) phase. No ECG ischemic changes were seen across any of the phases. Benign conduction abnormalities (sinus arrhythmia = 9; junctional rhythms = 4) occurred with some regularity during hypoxia. These abnormalities occurred with less frequency during the sham and recovery phases. It is possible that an altered breathing pattern or an inadequate washout period between phases might account for these findings. Overall, there was no significant relationship between the heart response and phase (p = .375). While the Alto2Lab did not produce any ECG changes indicative of an ischemic response, the present study used a small sample of healthy, recreationally-active participants. A larger study employing patients among higher risk categories would provide data that is not currently present in the literature and to which this trial cannot speak

Pre-Prandial Vinegar Ingestion Improves Two-Hour Glucose Control in Older, Type II Diabetics More Than Post-Prandial Walking

Background: Exercise engagement benefits diabetic patients through an insulin-like effect on muscle. Literature indicates that vinegar consumption may lower blood glucose levels. It is not currently clarified whether a relative amount of vinegar ingestion or a walking bout is more effective at controlling glucose in older, Type II diabetics during the acute phase following a meal. Purpose: The aim was to directly compare the impact of preferred-pace walking (15 min, postprandial) versus ingestion of a relative quantity of vinegar (0.3 g/kg) on two-hour glucose control. Methods: The two arms of the trial were completed in a randomized, crossover manner. Six Type II diabetic patients (Females = 5; Males = 1; Age = 70.5 ± 9.0 yrs.) enrolled and underwent baseline finger pricks to establish glucose levels. The test meal consisted of an 85 g bagel, 13 g of butter, and 237 mL of orange juice. On the respective days, the vinegar was diluted into 59 mL of orange juice and ingested before the meal or the subject completed a 15-min walk at 15 min post-meal. For both trials, glucose was checked every 30 min following the test meal. Results: One subject was removed from all present analysis due to medication-related non-compliance. For the vinegar trial, the resting heart rate was 72.0 (± 9.5) and baseline, 30-, 60-, 90-, and 120-min average blood glucose levels were: 117 (±12), 149 (±39), 172 (±49), 185 (±49), and 180 (±44) mg/dl. For the preferred walking speed phase, the resting heart rate was 75.5 (±15.6) and baseline, 30-, 60-, 90-, and 120-min average glucose levels were: 113 (±10), 147 (±53), 180 (±53), 208 (±72), and 206 (±71) mg/dl. Preferred walking speed was found to average 3.1 (± 1.5) kph and total steps averaged 1418 (±376). The between-arm comparison of glucose at 120-min trended towards significance (p = 0.081). Conclusions: Compared with a bout of walking, a relative quantity of vinegar may serve as a more suitable mechanism for older Type II diabetics to control acute spikes in glucose after a high carbohydrate meal. With an adequately-powered analysis, between-arm comparisons at multiple time-points would likely have achieved statistical significance. Nevertheless, the meaningfulness of the glucose control exhibited should not be lost due to the lack of statistical significance. Finally, the slow absolute preferred walking pace of many older adults may undermine the ability for walking to result in sufficient energy expenditure capable of subsequent glucose control

Tradition and Prudence in Locke's Exceptions to Toleration

Why did Locke exclude Catholics and atheists from toleration? Not, I contend, because he was trapped by his context, but because his prudential approach and practica ljudgments led him to traditiona ltexts. I make this argumentfirst by outlining the connections among prudential exceptionality, practical judgments, and traditional texts. I then describe important continuities betweenc onventional English understandings of the relationship between state and religion and Locke's writings on toleration, discuss Locke's conception of rights, and illustrate his use of prudential exceptions and distinctions. I conclude by arguing that Locke's problems are relevant to assessingc ontemporary liberal discussions of tolerationa nd the separation of state and religion that lean heavily on practical justification

Utility of Two iPhone Device Apps in Assessing Heart Rate at Rest and During Activity

Heart rate (HR) is a critical physiological variable used for prescribing exercise, assessing fitness level and tracking fitness improvements. Electrocardiography (ECG) stands as the criterion measure of HR. While recent development of HR-detecting mobile device applications (apps) has made evaluating HR more convenient; their degree of accuracy is unknown. Therefore, the purpose of this current study was to examine the accuracy and reliability of two-iPhone applications to detect HR at rest and during low-intensity exercise conditions. Eighteen female and 22 male subjects (26 + 9.5 yrs) were prepped for simultaneous detection of HR via three methods: ECG and two HR-detecting apps. App 1, a camera-based app called Azumio Instant Heart Rate (CAM), was used by placement of a finger over the camera lens of the mobile device. App 2, a microphone-based app called Heart Monitor by Bluespark, was employed via placement of an external microphone over the radial pulse. The participants underwent a series of 5-minute stages: seated rest followed by cycle then treadmill walking at low intensities. HR was recorded concurrently, at several time intervals from the three methods once a steady-state HR was reached. The means of the three devices were compared via ANOVA with the significance level set, a priori, at 0.05. Correlation analysis was employed to investigate relationships between the apps and ECG. No statistical difference was found between the CAM and ECG HR (p \u3e 0.05) during the resting and cycle stages. However, during the treadmill phase, there was a significant difference (p = 0.018) between CAM and ECG. Nevertheless, there was a significant (p \u3c 0.05), positive correlation between CAM and ECG under the resting, cycle and treadmill conditions (r = .966, r = .984, r = .877, respectively). Significant differences (p \u3c 0.05) were found for each condition when comparing ECG and MIC HR. Data also revealed poor correlations (p \u3e 0.05; r between -.004 and -.136) between MIC and ECG. The utility of CAM and MIC-based apps to detect HR remains in question as evidence appears to indicate exercise mode and app specificity. Caution should be shown when using these devices. The CAM-based app may accurately detect HR during resting and seated cycling but not during treadmill activity. The MIC-based app is not recommended for use in any condition. Of note, statistical significance may not mitigate usefulness when considering the accuracy of palpation. Additional research is necessary

Different Perspectives in Early Twentieth-Century Utah: A Love Story Between Lewis Gillilan and Ellen Benson

Lewis Gillilan and Ellen Benson were young adults who lived in Utah during the first decade of the twentieth century. Between the years 1909 and 1910 they engaged in a long-distance courtship, which ended in an elopement. In that period, they wrote many letters to each other which were full of details about what shaped their relationship. Such details ranged from romantic expressions to disagreements about religious beliefs. Their letters also frequently included references to their work and education, which tell a story of a state going through both agricultural, industrial, and social development. This paper explores themes present in Lewis and Ellen’s letters that connected them to Utah’s development, examines how they communicated love and affection across distance, and gives the reader an insight into who they were. Lewis and Ellen’s story was unique and multifaceted and offers a look into many less frequently discussed aspects of Utah’s history