Cash transfers and the mental health of young people: evidence from South Africa's child support grant

This study examines the longitudinal impact of the South African Child Support Grant (CSG) on risk for depression and life satisfaction among young people (15–19 years). We analysed data from the last three waves of the National Income Dynamics Study (NIDS), a nationally representative panel survey that took place every two years from 2008 to 2017. We used an instrumental variable (IV) approach that exploits multiple changes in age eligibility from 1998 to 2012. Depressive symptoms were assessed using an 8-item version of the Centre for Epidemiological Studies Depression Scale; participants who scored above 8 were considered at risk for depression. Life satisfaction was rated on a scale of 1 (‘very dissatisfied’) to 10 (‘very satisfied’); participants who scored 8 or above were classified as satisfied. We also examined impacts on educational deficit (≥2 years behind) and not being in education, employment or training (NEET) as secondary outcomes, as these are also important for mental health. Age eligibility strongly predicted CSG receipt at Wave 3. In instrumental variable models, CSG receipt did not influence the risk for depression (β = 0.10, SE = 0.10, p = 0.316), nor life satisfaction (β = −0.07, SE = 0.09, p = 0.420) at Wave 3, nor at Waves 4 or 5. Some improvements in educational deficit were observed at Wave 3 among CSG beneficiaries compared to non-beneficiaries. These results were robust to multiple specifications. CSG receipt did not improve the psychological wellbeing of adolescents and young adults, nor did it improve their education or employment outcomes. Our findings highlight the need to identify alternative social policies that address the root causes of youth social disadvantage, in conjunction with targeted approaches to improve the mental health of young South Africans living in poverty

NICMOS Imaging of Infrared-Luminous Galaxies

We present near-infrared images obtained with the HST NICMOS camera for a sample of 9 luminous (LIGs: L_IR (8-1000 microns) >~ 10^11 L_sun) and 15 ultra-luminous (ULIGS: L_IR >~ 10^12 L_sun) infrared galaxies. The sample includes representative systems classified as warm (f_25/f_60 > 0.2) and cold (f_25/f_60 <~ 0.2) based on the mid-infrared colors and systems with nuclear emission lines classified as HII (i.e. starburst), QSO, Seyfert and LINER. The morphologies of the sample galaxies are diverse and provide further support for the idea that they are created by the collision or interactions of spiral galaxies. Although no new nuclei are seen in the NICMOS images, the NICMOS images do reveal new spiral structures, bridges, and circumnuclear star clusters...Comment: LaTex, 27 pages with 14 gif and 4 jpg figures, AJ, in press, contour figures of the NICMOS images can be viewed at http://nedwww.ipac.caltech.edu/level5/Scoville/frames.htm

Discovery of a nuclear gas bar feeding the active nucleus in Circinus

We report the discovery of gas inflow motions towards the active nucleus of the Circinus galaxy caused by the non-axisymmetric potential of a nuclear gas bar. Evidence for dust associated with the bar comes from the HST/NICMOS H-K color map, whereas the streaming motions along the gas bar are seen in the velocity field of the H2 S(1)(1-0) emission line. The gas bar is about 100 pc long with a visual extinction in excess of 10 mag. Indication for the gaseous nature of this bar comes from the lack of a stellar counterpart even in the K band where the extinction is greatly reduced. We also use the NICMOS emission line images (Pa-alpha, [SiVI], and [FeII]) to study the innermost region of the ionization cones and the nuclear star forming activity. We discuss the possible relationship of these components with the gaseous bar.Comment: 14 pages, 7 figures (3 color plates), accepted for publication in Ap

Inhomogeneous superconductivity in organic conductors: role of disorder and magnetic field

Several experimental studies have shown the presence of spatially inhomogeneous phase coexistence of superconducting and non superconducting domains in low dimensional organic superconductors. The superconducting properties of these systems are found to be strongly dependent on the amount of disorder introduced in the sample regardless of its origin. The suppression of the superconducting transition temperature $T_c$ shows clear discrepancy with the result expected from the Abrikosov-Gor'kov law giving the behavior of $T_c$ with impurities. Based on the time dependent Ginzburg-Landau theory, we derive a model to account for the striking feature of $T_c$ in organic superconductors for different types of disorder by considering the segregated texture of the system. We show that the calculated $T_c$ quantitatively agrees with experiments. We also focus on the role of superconducting fluctuations on the upper critical fields $H_{c2}$ of layered superconductors showing slab structure where superconducting domains are sandwiched by non-superconducting regions. We found that $H_{c2}$ may be strongly enhanced by such fluctuations.Comment: to appear in Journal of Physics: Condensed Matte

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. Acknowledgments From the Berlin Laboratory, we thank Ingo Voigt for performing the injections of the two constructs into the oocytes, Bettina Seelhorst for her extensive technical assistance, Anna Thoma for taking specific care of the animals, and John Horn, Charite Core Facility for electron microscopy for performing expert analyses in ultra-cryosections with immunogold technique. Expert comments on the manuscript from Silke Frahm-Barske (Berlin) are also acknowledged. Special thanks to Bob Switzer at NeuroScience Associates Inc. for embedding, sectioning and staining mouse brains. This work was funded by TauRx Therapeutics, Singapore. C.R.H. and C.M.W. declare that they are officers in TauRx Therapeutics Ltd.Peer reviewedPublisher PD

Contribution of anadromous fish to the diet of European catfish in a large river system

Many anadromous fish species, when migrating from the sea to spawn in fresh waters, can potentially be a valuable prey for larger predatory fish, thereby efficiently linking these two ecosystems. Here, we assess the contribution of anadromous fish to the diet of European catfish (Silurus glanis) in a large river system (Garonne, southwestern France) using stable isotope analysis and allis shad (Alosa alosa) as an example of anadromous fish. Allis shad caught in the Garonne had a very distinct marine delta(13)C value, over 8 per thousand higher after lipid extraction compared to the mean delta(13)C value of all other potential freshwater prey fish. The delta(13)C values of European catfish varied considerably between these two extremes and some individuals were clearly specializing on freshwater prey, whereas others specialized on anadromous fish. The mean contribution of anadromous fish to the entire European catfish population was estimated to be between 53% and 65%, depending on the fractionation factor used for delta(13)C

Retail Price and Point of Sale Display of Tobacco in the UK: A Descriptive Study of Small Retailers

Background: Since the implementation of the 2002 Tobacco Advertising and Promotion Act, point-of-sale (PoS) tobacco displays are one of few remaining means of communication between the tobacco industry and customers in the UK. This study aimed to explore the characteristics of tobacco displays in a UK city, and particularly to assess the tobacco prices and promotional offers, types and pack sizes on display. Methods: Digital pictures of PoS displays were taken in 117 small retail shops in Nottingham in mid 2010. Data were analysed using Windows Photo Gallery software and SPSS version 16. Results: Just over half (52%) of cigarette packs on display were packs of 20, and 43 % packs of 10. Cigarette prices differed substantially between brands, ranging from £4.19 to £6.85 for 20-packs, and from £2.12 to £3.59 for 10-packs. Forty four percent of cigarette packs and 40 % of RYO (Roll-Your-Own) tobacco pouches, almost exclusively lower priced brands, were displayed with a pricemark, implying a promotional price offer. Eighty percent of 20-pack cigarette brand or brand variants on sale were priced below the EU-defined Most Popular Price Category (MPPC) for the UK in 2010; 45 % were priced below the Weighted Average Price (WAP), which replaced the MPPC in 2011. Conclusion: PoS displays communicate value by displaying a high proportion of lower cost brands, and smaller and hence lower-cost packs, and by displaying price discounts on packs. The MPPC substantially overestimated the prices at whic

What Powers Ultra-luminous IRAS Galaxies?

We present an ISO SWS and ISOPHOT-S, mid-infrared spectroscopic survey of 15 ultra-luminous IRAS galaxies. We combine the survey results with a detailed case study, based on near-IR and mm imaging spectroscopy, of one of the sample galaxies (UGC 5101). We compare the near- and mid-IR characteristics of these ultra-luminous galaxies to ISO and literature data of thirty starburst and active galactic nuclei (AGN), template galaxies. We find that 1) 70-80% of the ultra-luminous IRAS galaxies in our sample are predominantly powered by recently formed massive stars. 20-30% are powered by a central AGN. These conclusions are based on a new infrared 'diagnostic diagram' involving the ratio of high to low excitation mid-IR emission lines on the one hand, and on the strength of the 7.7um PAH feature on the other hand. 2) at least half of the sources probably have simultaneously an active nucleus and starburst activity in a 1-2 kpc diameter circum-nuclear disk/ring. 3) the mid-infrared emitting regions are highly obscured. After correction for these extinctions, we estimate that the star forming regions in ULIRGs have ages between 10^7 and 10^8 years, similar to but somewhat larger than those found in lower luminosity starburst galaxies. 4) in the sample we have studied there is no obvious trend for the AGN component to dominate in the most compact, and thus most advanced mergers. Instead, at any given time during the merger evolution, the time dependent compression of the circum-nuclear interstellar gas, the accretion rate onto the central black hole and the associated radiation efficiency may determine whether star formation or AGN activity dominates the luminosity of the system.Comment: 63 pages postscript (ex. MS Word), 11 postscript and 2 gif figures, submitted to ApJ. See also http://www.mpe-garching.mpg.de/ISO/preprint/MPE-IR-97003.htm

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages

Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-CoA, a precursor that is incorporated into cell-wall lipids. Arylamine N-acetyltransferase (NAT) is encoded within a gene cluster that is involved in the cholesterol sterol-ring degradation and is essential for intracellular survival. The ability of the NAT from M. tuberculosis (TBNAT) to utilise propionyl-CoA links it to the cholesterol-catabolism pathway. Deleting the nat gene or inhibiting the NAT enzyme prevents intracellular survival and results in depletion of cell-wall lipids. TBNAT has been investigated as a potential target for TB therapies. From a previous high-throughput screen, 3-benzoyl-4-phenyl-1-methylpiperidinol was identified as a selective inhibitor of prokaryotic NAT that exhibited antimycobacterial activity. The compound resulted in time-dependent irreversible inhibition of the NAT activity when tested against NAT from M. marinum (MMNAT). To further evaluate the antimycobacterial activity and the NAT inhibition of this compound, four piperidinol analogues were tested. All five compounds exert potent antimycobacterial activity against M. tuberculosis with MIC values of 2.3-16.9 µM. Treatment of the MMNAT enzyme with this set of inhibitors resulted in an irreversible time-dependent inhibition of NAT activity. Here we investigate the mechanism of NAT inhibition by studying protein-ligand interactions using mass spectrometry in combination with enzyme analysis and structure determination. We propose a covalent mechanism of NAT inhibition that involves the formation of a reactive intermediate and selective cysteine residue modification. These piperidinols present a unique class of antimycobacterial compounds that have a novel mode of action different from known anti-tubercular drugs