ACROKERATOSIS VERUCIFORMIS OF HOPF CLINICALLY MIMICKING AS NECROLYTIC ACRAL ERYTHEMA

Acrokeratosis verruciformis is very rare genodermatosis that was originally described by Hopf in 1931. A 29-years-old male presented to skin outpatient department with brown-colored hyperkeratotic plaques on dorsum of both feet that clinically mimicked as necrolytic acral erythema in our case. Biopsy was taken from lesion that shows hyperkeratosis, acanthosis, and slight papillomatosis along with well-circumscribed elevation of epidermis resembling church spires. No dyskeratotic cells were seen

Histopathological spectrum of endometrium in abnormal uterine bleeding

Background: Abnormal uterine bleeding (AUB) interferes with the quality of life of an otherwise healthy woman. Until the pathology underlying menorrhagia is, accurately diagnosed, proper therapy is hardly possible. The objective of the study was to analyze different histopathological patterns of endometrium in AUB and observe the incidence of various pathologies in different age groups and their relation to parity.Methods: This two-year prospective studywas done in the department of pathology in atertiary care centre, which included 250 cases of clinically diagnosed AUB patients were evaluated. Histopathological examination of endometrial biopsies and hysterectomy specimens were done, followed by clinical correlation.Results: Out of 250 cases of AUB, Premenopausal bleeding was seen in 216 cases (86.4%) and 34 cases (13.6%) had postmenopausal bleeding. The commonest finding observed in the study was proliferative phase endometrium (37.2%), followed by secretory endometrium (34%) and endometrial hyperplasia (16%). Disordered proliferative endometrium was seen in 2.4% of patients. Endometrial carcinoma was seen in 4 (1.6%) cases. Endometrial hyperplasia was seen mostly in the age group 41-50 years (27 cases). Two cases of endometrial carcinomas were presented after age 60 years.Conclusions: Our study revealed the highest incidence of AUB in the perimenopausal age group (41-50 years). Hence a thorough histopathological workup and clinical correlation are mandatory in cases of abnormal uterine bleeding

Safety and efficacy of trial of labour after cesarean

Background: In recent years, there are increasing numbers of cases which report for delivery after previous LSCS. Trial of labour after lower segment cesarean section can save them from repeat LSCS and its complications. Aim of study was conducted to evaluate the safety and efficacy of trial of labour after LSCS.Methods: This is a prospective study carried out at Mahatma Gandhi Hospital. One hundred pregnant patients with previous LSCS giving informed consent for trial of labour after cesarean section (TOLAC) were enrolled. Case selection was done as per the ACOG guidelines. Continuous fetal and maternal monitoring done by WHO partograph and cardiotocography. If there appeared any indication for repeat cesarean then emergency LSCS was done.Results: In this study, 80% of the enrolled patients delivered vaginally and 20% underwent repeat emergency LSCS. 2% of the enrolled patients underwent scar dehiscence. The patients in the active phase of labour on admission had more chances of successful vaginal birth after cesarean section (VBAC). Birth weight of more than 3000 grams is associated with lower rates of successful VBAC. There was no maternal mortality but 1% intrauterine fetal death due to scar rupture was there.Conclusions: TOLAC is safe and the success rates are good. Proper selection of cases with adequate fetal and maternal monitoring is required. So, once cesarean always cesarean is not a true dictum

VANET: Analysis of Black hole Attack using CBR/UDP Traffic Pattern with Hash Function and GPSR Routing Protocol

With momentum of time huge development occurred in the field of MANET and VANET. As we know when new technology emerges it came with many advanages but definitely some limitation must be there. In WSN security is one of biggest challenges which we need to tackle to implement adhoc network. Main reason behind this is dynamic topology of sensing node because nodes are dynamic in nature rather than static. As technology came into existence side by side unethical activity also take place which try to access the data illegally to gain personnel profit. There are so many types of attack possibilities are there in adhoc network. Attack can be classified into active and passive. In our research article oue main concern is on black hole attack. According to this attack a malicious node with high priority number is deployed in between other nodes. Now this malicious node access the data and sends acknowledgement to source that data received. Source node will think that acknowledgement is sent by destination node but actually it is sent by malicious node.  In this research article performance analysis of the black hole attack in Vehicular Ad Hoc Network is executed

A comparative study between abdominal plain radiography and ultrasonography in non-traumatic acute abdominal emergencies in tertiary care hospital

Background: Acute abdomen is a loose term frequently used to describe the acute abdominal pain in a subgroup of patients who are seriously ill developing suddenly, over a period of several hours or few days.Methods: It was a prospective comparative study between abdominal plain radiography and ultrasonography in non-traumatic acute abdominal emergencies in Tertiary Care Hospital.Results: All the included patients (140) were imaged with abdominal X-rays series (AAS) and Ultrasonography (US) by different blinded radiologists without conveying results to either. Final diagnosis was made on the basis of clinical findings / laboratory or biochemical findings /radiological evaluation /therapeutic response / operative findings / histopathological examination. The entire data was collected, recorded and statistically analyzed as per objectives. GIT system was most commonly involved, in 75/140 cases (53.57%). Most common diagnoses were acute appendicitis, KUB calculus disease and acute cholecystitis seen in 32/140 (22.86%), 24/140 (17.14%) and 21 (15%) cases respectively. US supersedes Provisional clinical diagnosis and Radiographic evaluation in diagnosing acute abdominal conditions with Sensitivity, Positive Predictive Value, False positive rate, False Negative rate and Diagnostic Accuracy as 90.71, 100, 0 ,9.28 and 90.71 percent respectively.Conclusions: We concluded that Plain X rays can be used as screening modality in the diagnosis of acute abdominal emergencies; however ultrasound examination is cheaper, non-invasive, quick, reliable and highly accurate modality in diagnosing the exact cause of pain and its origin in a patient presenting with an acute abdomen and thus helps the physician or surgeon to plan the timely management

Comparison of Landmark Versus ECG-Guided Technique for Correct Insertion of Central Venous Catheter in Paediatric Patients Undergoing Cardiothoracic Surgery

Background: Central venous catheters are inserted in internal jugular vein during cardiac surgeries in all patients. However, the length of the catheter should be correctly estimated and the tip of the CVC should be correctly placed to avoid various complications.  The primary objective of this study is to compare anatomical landmark technique versus using ECG-guided technique for the correct insertion length of the Central Venous Catheter. Methods: Prospective, randomized, interventional study was conducted on 72 patients of <12 years age. Patients were randomly allotted to two groups of 36 patients each (landmark and ECG). After induction, CVC cannulation was performed using either of the techniques in right IJV in all patients. Correct position of CVC was checked by obtaining post operative chest X rays in all patients. CVC tip position within 0.5cm above/below or at carina was considered as correct position. Using student t-tests and Chi square-tests analyses were performed. Results: In landmark group, CVC was positioned correctly in 22(61.11%) out of 36 patients as compared to 33 (91.67%) in the ECG group, (P = 0.006). The mean depth of CVC insertion was 9.05±1.66 and 8.26±1.41 in the landmark and ECG group respectively (P= 0.032). The landmark group had 12 (33.33%) patients with complications during the procedure, as compared to 3(8.33%) in the ECG-guided group, (P = 0.020). Conclusion: ECG-guided CVC insertion, a simple bedside technique was found more accurate with lesser complications for CVC tip placement than the landmark technique. ECG-guided CVC placement is therefore relatively more accurate, efficient, and safe

Development of iron oxide/activated carbon nanoparticle composite for the removal of Cr(VI), Cu(II) and Cd(II) ions from aqueous solution

Iron oxide (Fe3O4) and iron oxide/activated carbon (Fe3O4/AC) were fabricated by co-precipitation method for the removal of Cr(VI), Cu(II) and Cd(II) ions from aqueous solution in batch mode. These nanoparticles were characterized by BET, FTIR, XRD, SEM/TEM and VSM. The optimum conditions for the removal of ions were pH = 2 for Cr(VI) and 6 for Cu(II) and Cd (II), initial metal ion concentration = 50 mg L-1, nanoparticle dose = 50 mg/10 mL, temperature = 25 +/- 1 degrees C, shaking speed = 180 rpm and contact time = 3 h. The equilibrium data of ions sorption were well described by Langmuir, Freundlich, Redlich-Peterson and Intraparticle Diffusion model. The R-2 values obtained by Langmuir model were highest by Fe3O4/AC for Cr(VI) = 0.9994, Cu(II) = 0.9998 and Cd(II) = 0.9750. The temperature dependent study in the range of 288-328 K confirmed that the adsorption process was endothermic in nature. Desorption studies with 0.1M HCl stated that these nanoparticles can be regenerated effectively and can be used after four adsorption-desorption cycles without any mass loss.Peer reviewe

Anthocyanin-Rich Vegetables for Human Consumption—Focus on Potato, Sweetpotato and Tomato

Malnutrition, unhealthy diets, and lifestyle changes have become major risk factors for non-communicable diseases while adversely impacting economic growth and sustainable development. Anthocyanins, a group of flavonoids that are rich in fruits and vegetables, contribute positively to human health. This review focuses on genetic variation harnessed through crossbreeding and biotechnology-led approaches for developing anthocyanins-rich fruit and vegetable crops. Significant progress has been made in identifying genes involved in anthocyanin biosynthesis in various crops. Thus, the use of genetics has led to the development and release of anthocyanin-rich potato and sweet potato cultivars in Europe and the USA. The purple potato ’Kufri Neelkanth’ has been released for cultivation in northern India. In Europe, the anthocyanin-rich tomato cultivar ‘Sun Black’ developed via the introgression of Aft and atv genes has been released. The development of anthocyanin-rich food crops without any significant yield penalty has been due to the use of genetic engineering involving specific transcription factors or gene editing. Anthocyanin-rich food ingredients have the potential of being more nutritious than those devoid of anthocyanins. The inclusion of anthocyanins as a target characteristic in breeding programs can ensure the development of cultivars to meet the nutritional needs for human consumption in the developing world

Developing germplasm and promoting consumption of anthocyanin-rich grains for health benefits

Malnutrition, unhealthy diets, and lifestyle changes are the major risk factors for overweight and obesity-linked chronic diseases in humans adversely impact achieving sustainable development goals. Colored grains are a source of anthocyanins, a group of flavonoids, that contribute positively to human health. This review focuses on genetic variation harnessed through breeding and biotechnology tools for developing anthocyanin-rich grain crops. Agronomic practices, genotype × environment interactions, different stresses, seed development and seed maturity are factors that impact the content and composition of anthocyanins. Significant progress has been made in characterizing genes associated with anthocyanin biosynthesis in cereal and other crops. Breeding has led to the development and release of grain anthocyanin-rich crop cultivars in Europe, America and in some countries in Asia. Notably, genetic engineering utilizing specific transcription factors and gene editing has led to the development of anthocyanin-rich genetic variants without any significant yield penalty. A variety of food products derived from colored grains or flours are now available in grocery stores and supermarkets worldwide. The public perception about anthocyanin-rich food is positive, but availability, affordability, and willingness to pay a higher price than before limit consumption. Together with other seed nutrition traits in breeding programs the inclusion of anthocyanins can ensure the development of cultivars that meet nutrition needs of humans, especially in the developing world