Cognition and hypocognition: discursive and simulation-supported decision-making within complex systems

Homo sapiens is currently believed to have evolved in the African savannah several hundreds of thousands of years ago. Since then, human societies have become, through technological innovation and application, powerful influencers of the planet's ecological, hydrological and meteorological systems – for good and ill. They have experimented with many different systems of governance, in order to manage their societies and the environments they inhabit – using computer simulations as a tool to help make decisions concerning highly complex systems, is only the most recent of these. In questioning whether, when and how computer simulations should play a role in determining decision-making in these systems of governance, it is also worth reflecting on whether, when and how humans, or groups of humans, have the capability to make such decisions without the aid of such technology. This paper looks at and compares the characteristics of natural language-based and simulation-based decision-making. We argue that computational tools for decision-making can and should be complementary to natural language discourse approaches, but that this requires that both systems are used with their limitations in mind. All tools and approaches – physical, social and mental – have dangers when used inappropriately, but it seems unlikely humankind can survive without them. The challenge is how to do so

Introduction to urban food security in the Global South

This volume addresses the connections between three transformative processes in the Global South. First, the South is undergoing a rapid urban transition fueled by natural population increase and migration. Second, the cities of the South have witnessed major changes in the ways in which their food supply is organized, including new linkages to global processing and distribution networks and incorporation into global food markets. Third, there is a major upsurge in levels of food insecurity in the cities of the South. Undernutrition and overnutrition are both rising in most cities and towns. The chapters in this interdisciplinary volume provide new insights into these global processes and how they are experienced and responded to at the local level

The Role of the Membrane Potential in Chondrocyte Volume Regulation

Many cell types have significant negative resting membrane potentials (RMPs) resulting from the activity of potassium-selective and chloride-selective ion channels. In excitable cells, such as neurones, rapid changes in membrane permeability underlie the generation of action potentials. Chondrocytes have less negative RMPs and the role of the RMP is not clear. Here we examine the basis of the chondrocyte RMP and possible physiological benefits. We demonstrate that maintenance of the chondrocyte RMP involves gadolinium-sensitive cation channels. Pharmacological inhibition of these channels causes the RMP to become more negative (100 µM gadolinium: ΔVm = −30 ± 4 mV). Analysis of the gadolinium-sensitive conductance reveals a high permeability to calcium ions (PCa/PNa ≈80) with little selectivity between monovalent ions; similar to that reported elsewhere for TRPV5. Detection of TRPV5 by PCR and immunohistochemistry and the sensitivity of the RMP to the TRPV5 inhibitor econazole (ΔVm = −18 ± 3 mV) suggests that the RMP may be, in part, controlled by TRPV5. We investigated the physiological advantage of the relatively positive RMP using a mathematical model in which membrane stretch activates potassium channels allowing potassium efflux to oppose osmotic water uptake. At very negative RMP potassium efflux is negligible, but at more positive RMP it is sufficient to limit volume increase. In support of our model, cells clamped at −80 mV and challenged with a reduced osmotic potential swelled approximately twice as much as cells at +10 mV. The positive RMP may be a protective adaptation that allows chondrocytes to respond to the dramatic osmotic changes, with minimal changes in cell volume. J. Cell. Physiol. 226: 2979–2986, 2011. © 2011 Wiley-Liss, Inc

WIZE WIZARDS WORDS OF WIZDOM

In keeping with our Kiwiana theme, we will have a Wise Wizards Panel (yes, think Lord of the Rings movie) to answer interactive questioning from the delegates. Panel members are prestigious previous Geoffrey Dyson awardees, Life members, and ISBS Fellows: Professors Patria Hume, Bruce Elliott, Joe Hamill, Walter Herzog and Juris Terauds. Professor Walter Herzog is a Professor at the University of Calgary. Professor Joe Hamill is currently President of the International Society of Biomechanics. Professor Patria Hume was the inaugural SPRINZ Director at the Auckland University of Technology. Professor Juris Terauds and Professor Bruce Elliott are both Emeritus Professors. Professor Bruce Elliott’s philosophy has always been “a good question leads to beneficial research”. Come prepared to ask these wise biomechanists all the things you have ever wanted to know about biomechanics, as a discipline and a career. Via the session chairs Associate Professor Jacqueline Alderson and Professor Gareth Irwin, and using a dedicated feed arranged by our ISBS Social Media Coordinator Kylie Robinson, you will be able to ask questions like; What does it take to have a successful academic career as a biomechanist? Where are some of the best experiences that can be gained in applied biomechanics? What is your crystal ball prediction of what biomechanics specialists will focus on in 10 years time? We hope that delegates, especially student and early career researchers, take up this unique opportunity to gather insight from those in whose footsteps they walk

Eighteenth Year of the Gulf of Maine Environmental Monitoring Program

This report summarizes the metals and organic contaminant data associated with the collection and analyses of blue mussel (Mytilus edulis) tissue from selected sites along the Gulf of Maine coast during the 2008 sampling season. Contaminant monitoring is conducted by the Gulfwatch Program for the Gulf of Maine Council on the Marine Environment (GOMC). A subset of these data is compared with analytical results from earlier Gulfwatch monitoring (2001-2007). Statistical analyses are limited to descriptive measures of replicates from selected sampling sites and include: arithmetic means, and appropriate measures of variance. The primary purpose of this report is to present the current annual results, present graphical representation of spatial and temporal trends and identify potential outliers in order to provide investigators and other interested persons with contemporary information concerning water quality in the Gulf of Maine, as reflected by uptake into resident shellfish (mussels and clams)

Faecal glucocorticoid metabolite concentrations and their alteration post-defaecation in African wild dogs Lycaon pictus from South Africa

Non-invasive techniques for the monitoring of animal well-being, such as faecal hormone analysis, are increasingly becoming some of the most desirable methods for addressing practical conservation questions. Despite the widespread use of faecal hormone measurements for monitoring responses to stressors and its known applicability to African wild dogs Lycaon pictus, the potential influence of time of collection post-defaecation on stress-steroid concentrations in faecal matter has not yet been investigated. In the present study, we determined the rate at which African wild dog faecal glucocorticoid metabolite (fGCM) concentrations change over a 16-day period post-defaecation, in order to provide recommendations for best sampling practice. No significant changes in fGCM concentrations were found for the first 48 h post-defaecation. However, an approximately 30% increase in fGCM concentrations were already noted between day 1 and day 2, followed by a significant 150% increase at 96 h post-defaecation. We therefore suggest that respective faecal material should be collected within the first 24 h post-defaecation to ensure the reliability of fGCM analysis. In addition, we collected baseline data denoting the fGCM concentrations of captive African wild dogs sampled across three South African captive sites. Determined baseline fGCM concentrations differed between African wild dogs at the sites sampled. These data could be used in future studies aimed at identifying the key stressor complexes perceived by captive African wild dogs in order to improve management strategies.This study was funded in part by the National Research Foundation (NRF).am2019Anatomy and PhysiologyZoology and Entomolog

Faecal glucocorticoid metabolite concentrations and their alteration post-defaecation in African wild dogs Lycaon pictus from South Africa

Non-invasive techniques for the monitoring of animal well-being, such as faecal hormone analysis, are increasingly becoming some of the most desirable methods for addressing practical conservation questions. Despite the widespread use of faecal hormone measurements for monitoring responses to stressors and its known applicability to African wild dogs Lycaon pictus, the potential influence of time of collection post-defaecation on stress-steroid concentrations in faecal matter has not yet been investigated. In the present study, we determined the rate at which African wild dog faecal glucocorticoid metabolite (fGCM) concentrations change over a 16-day period post-defaecation, in order to provide recommendations for best sampling practice. No significant changes in fGCM concentrations were found for the first 48 h post-defaecation. However, an approximately 30% increase in fGCM concentrations were already noted between day 1 and day 2, followed by a significant 150% increase at 96 h post-defaecation. We therefore suggest that respective faecal material should be collected within the first 24 h post-defaecation to ensure the reliability of fGCM analysis. In addition, we collected baseline data denoting the fGCM concentrations of captive African wild dogs sampled across three South African captive sites. Determined baseline fGCM concentrations differed between African wild dogs at the sites sampled. These data could be used in future studies aimed at identifying the key stressor complexes perceived by captive African wild dogs in order to improve management strategies.This study was funded in part by the National Research Foundation (NRF).am2019Anatomy and PhysiologyZoology and Entomolog

Faecal glucocorticoid metabolite concentrations and their alteration post-defaecation in African wild dogs Lycaon pictus from South Africa

Non-invasive techniques for the monitoring of animal well-being, such as faecal hormone analysis, are increasingly becoming some of the most desirable methods for addressing practical conservation questions. Despite the widespread use of faecal hormone measurements for monitoring responses to stressors and its known applicability to African wild dogs Lycaon pictus, the potential influence of time of collection post-defaecation on stress-steroid concentrations in faecal matter has not yet been investigated. In the present study, we determined the rate at which African wild dog faecal glucocorticoid metabolite (fGCM) concentrations change over a 16-day period post-defaecation, in order to provide recommendations for best sampling practice. No significant changes in fGCM concentrations were found for the first 48 h post-defaecation. However, an approximately 30% increase in fGCM concentrations were already noted between day 1 and day 2, followed by a significant 150% increase at 96 h post-defaecation. We therefore suggest that respective faecal material should be collected within the first 24 h post-defaecation to ensure the reliability of fGCM analysis. In addition, we collected baseline data denoting the fGCM concentrations of captive African wild dogs sampled across three South African captive sites. Determined baseline fGCM concentrations differed between African wild dogs at the sites sampled. These data could be used in future studies aimed at identifying the key stressor complexes perceived by captive African wild dogs in order to improve management strategies.This study was funded in part by the National Research Foundation (NRF).am2019Anatomy and PhysiologyZoology and Entomolog