8 research outputs found

    Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

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    Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when = 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution

    Integrating phytolith and micromorphological research in Central Anatolia: insights into Early Holocene human-plant-animal dynamics

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    27th EAA Annual Meeting (Kiel Virtual, 2021)The tight integration of phytolith and micromorphological methodologies is a very promising line of work in environmental archaeology, since it allows us to combine the strengths of both quantitative (i.e. concentrations of micro-remains) and qualitative (i.e. micro-contextual) studies. In this paper, we present case studies from the Central Anatolian Neolithic record to illustrate the many advantages associated with this interdisciplinary approach, particularly when capable of expanding/dismissing functional interpretations of archaeological contexts defined by field observations. We then evaluate these results under the light of ethnographic research in modern Turkish villages, highlighting how these investigations contribute to refining archaeological interpretations of deposits and embedded micro-remains from comparable contexts. Phytolith spot samples were collected from the sediment blocks before preparation for manufacture into thin-sections, resulting in the strong association of microfossil and micromorphological data. Results demonstrate how the combination of geo- and bio-markers leads to solid interpretations on key archaeological issues such as uses and concepts of space, landscape exploitation and herd management, in particular feeding regimes and dung use. Specifically, micromorphology has made significant contributions to our understanding of the depositional pathways and taphonomic alterations of plant contents in the studied contexts, whereasphytolith analyses of spot samples have allowed us to overcome the limitations posed by the observation of plant microfossils in micromorphological thin-sections. Through this combination, depositional processes, ecological choices and post-depositional alterations are identified and understood more accurately

    Microarchaeology: making visible the invisible archaeological record through high resolution integrated approaches

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    Although microarchaeological techniques are being increasingly applied to reconstructing human-environment dynamics within built environments from the Early Holocene onwards, its integration particularly in archaeological research programs based on historical periods, is far from systematic. Over the last decades, the study of the invisible microscopic record through the application of high-resolution methodologies in the fields of geoarchaeology, archaeobiology and biochemistry, including microbiological remains and molecular signatures from a varied range of contexts, has contributed significantly to improve our knowledge about landscapes and environmental conditions, water availability, food production, energy supply, technology, site formation processes and the use of space, contributing to a better understanding of changing social, economic and cultural dynamics of past populations through time. The aim of this international conference is to bring together different perspectives derived from multi-proxy techniques applied to a varied range of archaeological contexts, from early built environments to complex urban societies in the Central-Western Mediterranean, but not limited to these. Further, it intends to 1) review current methodologies, recent applications, and advances in the study of the microarchaeological record; 2) to address the challenges of integrating high-resolution approaches; 3) to evaluate the contribution of experimental and ethnoarchaeological comparative records; 4) to discuss the role of microarchaeological records in exploring major research questions; and 5) to suggest possible future perspectives and directions
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