Analysis of heritability across the clinical phenotypes of frontotemporal dementia and the frequency of the C9ORF72 in a colombian population

La demencia frontotemporal (FTD) es una condición altamente hereditaria. Hasta el 40% de la FTD es familiar y se estima que entre el 15% y el 40% se debe a mutaciones de un solo gen. Se ha estimado que las expansiones de repeticiones de hexanucleótidos G4C2 en el gen C9ORF72 pueden explicar hasta el 37,5% de los casos familiares de FTD, especialmente en poblaciones de origen caucásico. El propósito de este artículo es evaluar el riesgo hereditario a través de los fenotipos clínicos de FTD y la frecuencia de la expansión de G4C2 en una cohorte colombiana con diagnóstico de FTD. Métodos: Un total de 132 pacientes con DFT fueron diagnosticados de acuerdo con los criterios establecidos en la variante conductual de DFT, la variante de PPA logopénica, la PPA agramática no fluida y la variante semántica de la PPA. El riesgo hereditario a través de los fenotipos clínicos se estableció en cuatro categorías que indican la relación patogénica de la mutación: alto, medio, bajo y aparentemente esporádico, en base a los propuestos por Wood y colaboradores. Todos los sujetos también fueron examinados para la expansión de hexanucleótidos C9ORF72 (definida como> 30 repeticiones). Resultados: No hubo diferencias significativas en las características demográficas de los pacientes entre los fenotipos clínicos de DFT. El fenotipo de mayor tasa fue bvFTD (62,12%). De acuerdo con la clasificación de riesgo, encontramos que 72 (54,4%) cumplieron con los criterios para los casos esporádicos; para los casos familiares, 23 (17,4%) cumplieron con los criterios de alto riesgo, 23 (17,4%) cumplieron con los de bajo riesgo y 14 (10,6%) cumplieron con los criterios para ser clasificados como sujetos a riesgo medio. La frecuencia de expansión de C9ORF72 fue de 0,76% (1/132). Conclusión: La heredabilidad FTD presentada en esta investigación fue muy similar a los resultados reportados en la literatura. La frecuencia de expansión de C9ORF72 fue baja. Colombia es un país triétnico, con una alta frecuencia de marcadores genéticos amerindios; esto muestra coherencia con los resultados actuales de una baja frecuencia de repetición. Este estudio proporciona un informe inicial de la frecuencia de las expansiones de repetición de hexanucleótidos en C9ORF72 en pacientes con FTD en una población colombiana y allana el camino para un estudio adicional de las posibles causas genéticas de FTD en Colombia.Q2Frontotemporal dementia (FTD) is a highly heritable condition. Up to 40% of FTD is familial and an estimated 15% to 40% is due to single-gene mutations. It has been estimated that the G4C2 hexanucleotide repeat expansions in the C9ORF72 gene can explain up to 37.5% of the familial cases of FTD, especially in populations of Caucasian origin. The purpose of this paper is to evaluate hereditary risk across the clinical phenotypes of FTD and the frequency of the G4C2 expansion in a Colombian cohort diagnosed with FTD. Methods: A total of 132 FTD patients were diagnosed according to established criteria in the behavioral variant FTD, logopenic variant PPA, non-fluent agrammatic PPA, and semantic variant PPA. Hereditary risk across the clinical phenotypes was established in four categories that indicate the pathogenic relationship of the mutation: high, medium, low, and apparently sporadic, based on those proposed by Wood and collaborators. All subjects were also examined for C9ORF72 hexanucleotide expansion (defined as >30 repetitions). Results: There were no significant differences in the demographic characteristics of the patients between the clinical phenotypes of FTD. The higher rate phenotype was bvFTD (62.12%). In accordance with the risk classification, we found that 72 (54.4%) complied with the criteria for the sporadic cases; for the familial cases, 23 (17.4%) fulfilled the high-risk criteria, 23 (17.4%) fulfilled the low risk criteria, and 14 (10.6%) fulfilled the criteria to be classified as subject to medium risk. C9ORF72 expansion frequency was 0.76% (1/132). Conclusion: The FTD heritability presented in this research was very similar to the results reported in the literature. The C9ORF72 expansion frequency was low. Colombia is a triethnic country, with a high frequency of genetic Amerindian markers; this shows consistency with the present results of a low repetition frequency. This study provides an initial report of the frequency for the hexanucleotide repeat expansions in C9ORF72 in patients with FTD in a Colombian population and paves the way for further study of the possible genetic causes of FTD in Colombia.https://orcid.org/0000-0001-6529-7077https://scholar.google.com/citations?hl=es&user=kaGongoAAAAJ&view_op=list_works&sortby=pubdatehttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000055000&lang=esRevista Nacional - Indexad

Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance. A cross-sectional study

Background Motoric Cognitive Risk Syndrome (MCR) is a predementia stage where slow gait speed and subjective memory complaints are present. The purpose of this study was to estimate the prevalence of MCR and assess its relationship with sociodemographic factors and chronic conditions. Methods This is a secondary analysis of the SABE Colombia study conducted in 2015. The analytic sample consisted of 17·577 participants. After determining MCR prevalence, logistic regression was performed to examine the correlates of MCR. Findings The prevalence of MCR was 10·71 %. The median age was 71 years and women composed 74·63 % of the MCR group. After adjusting for confounding variables MCR was associated with increasing age (OR 1·69, CI 1·43 - 1·92), no or low education (OR 1·99, CI 1·67- 2·37), MMSE (OR 0·93, CI 0·91 - 0·95) and chronic conditions such as mental disorders (OR 1·36, CI 1·11-1·67), history of myocardial infarction (OR 1·24, CI 1·04 - 1·47), hypertension (OR 1·23, CI 1·08 - 1·40) and diabetes (OR 1.18, CI 1.01 – 1.37). Interpretation This study found a prevalence of 10·71 % of MCR in Colombian older adults. Additionally, MCR was associated with chronic conditions and sociodemographic factors identified in prior studies. These results increase the awareness of a novel predementia stage whose identification can be performed by clinicians in the outpatient clinic, minimizing the cost of a full neuropsychologic evaluation performed in a memory clinic.publishedVersio

Effectiveness of treatments in Neuromyelitis optica to modify the course of disease in adult patients. Systematic review of literature.

El trastorno del espectro de la neuromielitis óptica (NMOSD) es una enfermedad inflamatoria, que se manifiesta principalmente como episodios recurrentes de neuritis o mielitis óptica que causan una discapacidad importante. El diagnóstico temprano y el pronto inicio de la terapia inmunosupresora son cruciales para reducir las recaídas, la discapacidad y la mortalidad. Aunque hay pocos ensayos controlados aleatorios prospectivos, varios medicamentos han demostrado ser efectivos y seguros. La azatioprina y el rituximab representan el estándar de atención y se utilizan como agentes de tratamiento de primera línea en todo el mundo. Sin embargo, estudios recientes han revelado nuevas terapias, como los anticuerpos monoclonales. Para hacer recomendaciones de tratamiento y pautas de manejo, es imperativo definir un estándar de atención adecuado.Neuromyelitis Optica spectrum disorder (NMOSD) is an inflammatory disease, which manifests mostly as recurrent episodes of optic neuritis or myelitis that cause important disability. Early diagnosis and prompt initiation of immunosuppressive therapy are crucial in reducing relapses, disability, and mortality. Even though, there are few prospective randomized controlled trials, several drugs have proved to be both effective and safe. Azathioprine and Rituximab represent the standard of care and are used as first-line treatment agents worldwide. However, recent studies have unveiled new therapies, such as monoclonal antibodies. To make treatment recommendations and management guidelines, it is imperative to define an appropriate standard of care.N/

Muscular function as an alternative to identify cognitive impairment : a secondary analysis from SABE Colombia

Antecedentes: La identificación del deterioro cognitivo se basa tradicionalmente en la pruebas neuropsicológicas y biomarcadores que no están ampliamente disponibles. Este estudio tuvo como objetivo establecer la asociación entre la función motora (velocidad de la marcha y fuerza) y el rendimiento cognitivo en el Mini-Examen del Estado Mental, a nivel mundial y por dominios. Un objetivo secundario fue calcular un punto de corte para la velocidad de la marcha y la prensión manual. fuerza para clasificar a los adultos mayores como con deterioro cognitivo. Métodos: Este es un análisis secundario de SABE Colombia (Salud, Bienestar & Envejecimiento), encuesta realizada en 2015 sobre salud, bienestar y envejecimiento en Colombia. Este estudio utilizó modelos de regresión lineal para buscar un asociación entre la función motora y el rendimiento cognitivo. La precisión del motor las mediciones de función en la identificación del deterioro cognitivo se evaluaron con el receptor curvas características de funcionamiento (ROC). Este estudio también analizó otros aspectos clínicos y variables sociodemográficas. Resultados: La velocidad de la marcha se asoció con la orientación (r2 = 0,16), idioma (r2 = 0.15), recordar memoria (r2 = 0.14), y contando (r2 = 0,08). Del mismo modo, la empuñadura la fuerza se asoció con la orientación (r2 = 0,175), idioma (r2 = 0.164), recordar memoria (r2 = 0.137), y contando (r2 = 0,08). Para diferenciar a los adultos mayores con y sin deterioro cognitivo, se tuvo un punto de corte de velocidad de la marcha de 0,59 m/s. un área bajo la curva (AUC) de 0,629 (0,613–0,646) y un agarre débil (resistencia por debajo de 17,5 kg) tenía un AUC de 0,653 (0,645-0,661). los puntos de corte para la fuerza de agarre y la velocidad de la marcha fueron significativamente mayores en los participantes masculinos. García-Cifuentes et al. Función muscular y deterioro cognitivo Conclusiones: La velocidad de la marcha y la fuerza de prensión se asocian de manera similar con la desempeño cognitivo, exhibiendo la asociación más extensa con la orientación y dominios lingüísticos del Mini-Examen del Estado Mental. Velocidad de marcha y prensión cualquier médico puede medir fácilmente la fuerza, y demuestran ser útiles para la detección herramientas para detectar el deterioro cognitivo. Palabras clave: velocidad de la marcha, fuerza de prensión manual, deterioro cognitivo, biomarcador, demencia preclínica, motora disfunciónQ2Q2Background: Identification of cognitive impairment is based traditionally on the neuropsychological tests and biomarkers that are not available widely. This study aimed to establish the association between motor function (gait speed and handgrip strength) and cognitive performance in the Mini-Mental State Examination, globally and by domains. A secondary goal was calculating a cut-off point for gait speed and handgrip strength to classify older adults as cognitively impaired. Methods: This is a secondary analysis of SABE Colombia (Salud, Bienestar & Envejecimiento), a survey that was conducted in 2015 on health, wellbeing, and aging in Colombia. This study used linear regression models to search for an association between motor function and cognitive performance. The accuracy of motor function measurements in identifying cognitive impairment was assessed with receiver operating characteristic (ROC) curves. This study also analyzed other clinical and sociodemographical variables. Results: Gait speed was associated with orientation (r2 = 0.16), language (r2 = 0.15), recall memory (r2 = 0.14), and counting (r2 = 0.08). Similarly, handgrip strength was associated with orientation (r2 = 0.175), language (r2 = 0.164), recall memory (r2 = 0.137), and counting (r2 = 0.08). To differentiate older adults with and without cognitive impairment, a gait speed cut-off point of 0.59 m/s had an area under the curve (AUC) of 0.629 (0.613–0.646), and a weak handgrip (strength below 17.5 kg) had an AUC of 0.653 (0.645-0.661). The cut-off points for handgrip strength and gait speed were significantly higher in male participants. Conclusions: Gait speed and handgrip strength are similarly associated with the cognitive performance, exhibiting the most extensive association with orientation and language domains of the Mini-Mental State Examination. Gait speed and handgrip strength can easily be measured by any clinician, and they prove to be useful screening tools to detect cognitive impairment.https://orcid.org/0000-0001-5680-7880https://scholar.google.com/citations?view_op=search_authors&mauthors=carlos+alberto+cano-gutierrez&hl=es&oi=aohttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000054895&lang=nullRevista Nacional - Indexad

Characterization of patients with advanced dementia hospitalized in the geriatric unit in a high complexity hospital

OBJETIVO: Describir y analizar las características clínicas, funcionales, nutricionales y sociales de pacientes con demencia avanzada (DA), hospitalizados a cargo del servicio de geriatría del Hospital Universitario San Ignacio (HUSI) y su relación con desenlaces hospitalarios, comparando con demencia no avanzada. MÉTODOS: se realizó un estudio observacional, descriptivo en pacientes ancianos hospitalizados por el servicio de geriatría del HUSI, con revisión retrospectiva de historias clínicas en el perioro de tiempo entre enero del 2016 y diciembre del 2017. La variable dependiente fue DA. Se realizó análisis univariado, bivariado y multivariado. RESULTADOS: de 1091 pacientes con demencia, 606 tenían diagnóstico de DA. La mediana de edad fue de 86 años y la prevalencia de mujeres fue mayor (57,3%). En los sujetos con DA, comparados con el grupo de demencia, se encontró mayor porcentaje de malnutrición (91,1%), úlceras por presión (26,2%), delirium (67,2%), polifarmacia (68,3%), estancia hospitalaria (5 días), complicaciones (10,6%) y mortalidad (16,9%). Se encontró una mayor asociación de malnutrición con DA (OR=2,80, IC=1,94-4,06, p<0,00), así mismo con polifarmacia (OR=1,41, IC=1,07-1,86, p=0,012), delirium (OR=2,24, IC=1,72-2,92, p<0,00), úlceras por presión (OR=3,75, IC=2,45-5,73, p<0,00) y mortalidad (OR=2,21, IC=1,42-3,44, p<0,00). DISCUSIÓN: la avanzada edad de nuestros pacientes puede ser determinante en el alto porcentaje de demencia encontrada. La DA condiciona a mayor compromiso en el curso de diferentes desenlaces hospitalarios como malnutrición, polifarmacia, delirium, úlceras y mortalidad. Lo anterior hace necesaria una valoración geriátrica integral del paciente anciano con demencia para mejorar el curso clínico de la hospitalización.Artículo original15-21OBJECTIVE: To describe and analyze the clinical characteristics, functionality, nutritional, and social aspects in patients with Advance Dementia (AD), and to hospitalized in the geriatric unit in the Hospital Universitario San Ignacio (HUSI) and it how it is related with hospital outcomes, compare with no advanced dementia. METHODS: A cross-sectional study was conduct, in patient hospitalized in the geriatric unit in the HUSI, with a retrospective review of electronic medical charts from January of 2016 to December 2017. The dependent variable was AD, a univariate, bivariate and multivariate analysis was made. RESULTS: 1091 patients had dementia, 606 with AD, the median age was 86 years and the women prevalence were (57.3%) higher than men. In the AD group, compared with those with dementia, had high percentage of malnutrition (91.1%), pressure ulcers (26.2%), delirium (67.2%), polypharmacy (68.3%), longer hospital admission (median of 5 days vs 4 days), medical complication (10.6%), and mortality (16.9%). We found a higher association with malnutrition with AD (OR=2.80, CI=1.94-4.06, p<0.00), polypharmacy (OR=1.41 CI=1.07-1.86, p=0.012), delirium (OR=2.24, CI=1.72-2.92, p<0.00), pressure ulcers (OR=3.75, CI= 2.45- 5.73, p<0.00) and mortality (OR=2.21,CI=1.42-3.44, p<0.00). DISCUSSION: The advance aged in our patients, might be a determinant in the high percentage of dementia that we found. AD is an entity that predispose to higher clinical outcomes as malnutrition, polypharmacy, delirium, pressure ulcers and mortality. As previously shown there is a need for a comprenhensive geriatric assessment in elderly with dementia, to improve hospital outcomes

Self-reported glaucoma prevalence and related factors, contribution to reported visual impairment, and functional burden in a cross-sectional study in Colombia

Objetivo Describir la prevalencia autorreportada de glaucoma en adultos mayores colombianos, enfatizando los factores de riesgo más importantes y las alteraciones funcionales de la vida diaria asociadas. Métodos Este es un análisis secundario de la encuesta de Salud, Bienestar y Envejecimiento realizada en el año 2015. El diagnóstico de glaucoma se obtuvo del autoinforme. Las variables funcionales se evaluaron mediante cuestionarios de actividades de la vida diaria. Se realizó un análisis descriptivo seguido de modelos de regresión bivariados y multivariados ajustando por variables de confusión. Resultados La prevalencia autoinformada de glaucoma fue de 5,67%, con mayor tasa en mujeres, OR 1,22 (1,13–1,40) p = ,003, mayor edad OR 1,02 (1,01–1,02) p < ,001, y con educación superior OR 1,38 (1,28 –1.50) p < .001. El glaucoma se asoció de forma independiente con diabetes OR 1,37 (1,18–1,61) p  < ,001 e hipertensión 1,26 (1,08–1,46) p = ,003. También mostró correlaciones estadísticamente significativas con mala SSR OR 1.15 (1.02–1.32) p < .001, discapacidad visual autoinformada 1.73 (1.50–2.01) p < .001 y deterioro en el manejo del dinero OR 1.59 (1.16–2.08) p = .002, compras de comestibles OR 1.57 (1.26–1.96) p < .001 y preparación de comidas OR 1.31 (1.06–1.63) p  = .013 y haber tenido caídas en el último año OR 1.14 (1.01–1.31) p = 0.041. Conclusión Nuestros hallazgos sugieren que la prevalencia autoinformada de glaucoma en adultos mayores en Colombia es más alta que los datos informados. El glaucoma y la discapacidad visual en adultos mayores representan un problema de salud pública, ya que el glaucoma se asoció con resultados adversos como pérdida funcional y riesgo de caídas, afectando la calidad de vida y su participación en la sociedad.Q2Q2Purpose Describe the self-reported prevalence of glaucoma in Colombian older adults, emphasizing the most important risk factors and associated daily-life functional alterations. Methods This a secondary analysis of the Health, Wellness, and Aging survey conducted in the year 2015. Diagnosis of glaucoma was obtained from self-report. Functional variables were assessed through activities of daily living questionnaires. A descriptive analysis followed by bivariate and multivariate regression models adjusting for confounding variables was conducted. Results Self-reported prevalence of glaucoma was 5.67%, with higher rate in women, OR 1.22 (1.13–1.40) p = .003, older age OR 1.02 (1.01–1.02) p < .001, and with higher education OR 1.38 (1.28–1.50) p < .001. Glaucoma was independently associated with diabetes OR 1.37 (1.18–1.61) p  < .001 and hypertension 1.26 (1.08–1.46) p = .003. It also showed statistically significant correlations with poor SRH OR 1.15 (1.02–1.32) p < .001, self-reported visual impairment 1.73 (1.50–2.01) p < .001, and impairment in money management OR 1.59 (1.16–2.08) p  = .002, grocery shopping OR 1.57 (1.26–1.96) p < .001 and preparing meals OR 1.31 (1.06–1.63) p  = .013 and having had falls during the last year OR 1.14 (1.01–1.31) p = 0.041. Conclusion Our findings suggest the self-reported prevalence of glaucoma in older adults in Colombia to be higher than reported data. Glaucoma and visual impairment in older adults represent a public health concern, since glaucoma was associated with adverse outcomes like functional loss and risk of falling, affecting the quality of life and their participation in society.https://orcid.org/0000-0001-5680-7880https://scholar.google.com/citations?view_op=search_authors&mauthors=carlos+alberto+cano-gutierrez&hl=es&oi=aohttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000054895Revista Internacional - IndexadaS

Body mass index, performance on activities of daily living and cognition: analysis in two different populations

Background With this study, we aim to determine the associations of the different categories of the body mass index (BMI) with activities of daily living (ADL) and cognitive performance in two different populations living in the community; Colombian and South Korean older adults. Methods We performed a cross-sectional analysis of two surveys separately; The Survey on Health, Well-Being, and Aging in Colombia (SABE) (n = 23,343) and the Korean Longitudinal Study of aging (KLoSA) (n = 4556). Participants older than 50 years were selected from rural and urban areas achieving a representative sample. Here we investigated the association between BMI categories with function using zero-inflated negative binomial regressions, and with cognition using logistic regression models. Results After adjustment, in Colombia, underweight was associated with an impaired score on the Mini-mental State Examination (MMSE) and worse performance in the instrumental activities of daily living (IADL). Also, being overweight was associated with a better score on the MMSE and the IADL. For both outcomes education level significantly influenced the predictions. In South Korea, there were no significant associations for cognition, IADL, or basic activities of daily living (BADL). Conclusions In the Colombian population, underweight, was associated with reduced cognitive performance and daily functioning. Additionally, being overweight but not obese was associated with better cognition and daily functioning. In South Korea, there were no significant associations between BMI and cognition, IADL, or BADL.publishedVersio

Two-Way bridge between muscular dysfunction and cognitive impairment : secondary analyses of SABE - Bogota study

Abstract: Background and objective: Muscular dysfunction and cognitive impairment are both disabling states, affecting especially the elderly. Thus, are important subjects of research. Our goal is to describe the association between these two entities in the elderly. Methods: This is a secondary analysis from the SABE 2012 Bogota survey, which is a cross-sectional study. We define muscular dysfunction as an abnormal result in gait speed and/or handgrip strength tasks. Cognitive impairment was defined as an abnormal result in Mini Mental State Examination. Other independent variables were measured. Results: A total of 1,564 older adults were included in the analysis. Cognitive impairment showed statistically significant association with both low handgrip strength (OR: 2.25; CI 1.52 – 3.33) and low gait speed (OR: 2.76; CI 1.83 – 4.15) in the adjusted model. Conclusion: In older adults, muscular dysfunction is associated with cognitive impairment. New studies should address the causality and temporality of this relationship.Completo2-3Abstract: Background and objective: Muscular dysfunction and cognitive impairment are both disabling states, affecting especially the elderly. Thus, are important subjects of research. Our goal is to describe the association between these two entities in the elderly. Methods: This is a secondary analysis from the SABE 2012 Bogota survey, which is a cross-sectional study. We define muscular dysfunction as an abnormal result in gait speed and/or handgrip strength tasks. Cognitive impairment was defined as an abnormal result in Mini Mental State Examination. Other independent variables were measured. Results: A total of 1,564 older adults were included in the analysis. Cognitive impairment showed statistically significant association with both low handgrip strength (OR: 2.25; CI 1.52 – 3.33) and low gait speed (OR: 2.76; CI 1.83 – 4.15) in the adjusted model. Conclusion: In older adults, muscular dysfunction is associated with cognitive impairment. New studies should address the causality and temporality of this relationship

Socioeconomic Disparities and Gender Inequalities in Dementia: a Community-Dwelling Population Study from a Middle-Income Country

The proportion of the world\u27s older adults and of its dementia cases is increasing in low and middle-income countries. This is particularly true in Colombia. There, the number of individuals with dementia may increase five-fold by 2050. Yet research is lacking on dementia in such settings. This work estimates the prevalence of dementia in a community-dwelling population in Colombia. It also assesses how gender-based differences in cardiovascular conditions and socioeconomic disparities affect dementia. This work analyzes data on 2000 respondents at least 60 years of age in the Health, Well-Being, And Aging (SABE) study in Bogota. Respondents with dementia are those who have cognitive impairment and at least two limitations in instrumental activities of daily living. The SABE study finds 8.4% of respondents have dementia. Age, cardiovascular risks, and socioeconomic disparities contributed to higher odds of dementia. The contributors to dementia can differ for men and women. For example, socioeconomic disparities were a larger contributor to dementia for women than men. The findings support the cognitive reserve hypothesis on dementia. This holds that pre-existing cognitive processes and compensatory mechanisms influence dementia. Women in Latin America are more likely to suffer from socioeconomic disparities that limit their cognitive reserve. This research points to several policy implications that can help offset these disparities and reduce the prevalence of dementia

Clinical and Therapeutic Approach to Autoimmune Encephalitis

Introducción: La encefalitis autoinmune es una condición inflamatoria del cerebro cuya incidencia aumentó notoriamente durante 2010-2020, y sus manifestaciones psiquiátricas requieren un abordaje interdisciplinario entre el psiquiatra y el neurólogo. Objetivo: Presentar una revisión narrativa acerca del abordaje diagnóstico y terapéutico en la encefalitis autoinmune. Métodos: Revisión narrativa de los artículos más relevantes en el área en las bases de datos Medline, Scopus y Embase. Resultados: La encefalitis autoinmune comprende un amplio espectro de síntomas neurológicos y psiquiátricos: psicosis, cambios comportamentales, déficits cognitivos y disminución del nivel de conciencia. En el análisis diagnóstico es fundamental considerar una patología autoinmune subyacente y descartar condiciones infecciosas, metabólicas y vasculares. Actualmente, los criterios diagnósticos apoyan el reconocimiento de esta patología e incluyen el estudio con electroencefalograma, resonancia magnética, análisis del líquido cefalorraquídeo y pruebas de autoanticuerpos antineuronales, ya disponibles en Colombia. El tratamiento inmunosupresor debe iniciarse lo antes posible para evitar la aparición de complicaciones graves y se asocia con un mejor pronóstico. Conclusiones: Un óptimo abordaje clínico basado en los criterios diagnósticos definidos es fundamental para administrar tempranamente un manejo inmunoterapéutico, ya que ha demostrado mejorar significativamente las tasas de supervivencia en esta enfermedad.Q4Introduction: Autoimmune encephalitis is aninflammatory brain condition with an incidence thathas increased significantly in the last decade. Since itspsychiatric manifestations requires an interdisciplinary approach between psychiatrist and neurologist. Objective: To present a narrative review about the diagnosticand therapeutic approach in autoimmune encephalitis. Methods: A narrative review of the most relevant articles in the area was made in the Medline, Scopus and Embase databases. Results: Autoimmune encephalitisen compasses a huge spectrum of neurological andpsychiatric symptoms including psychosis, behavioral changes, cognitive deficits, and decreased level of consciousness. In the diagnostic analysis, considering an underlying autoimmune pathology is essential, once infectious, metabolic, and vascular causes are ruled out. The current diagnostic criteria support the recognitionof this pathology and include electroencephalography, magnetic resonance imaging, cerebrospinal fluid analysis and anti-neuronal autoantibody tests, now available inour country. Immunotherapy should be started as soon as possible to avoid the appearance of serious complications and is associated with a better prognosis. Conclusions: anoptimal clinical approach based on the defined diagnostic criteria is essential to administer immunotherapy early, which has been shown to significantly improve survivalrates in this disease.https://orcid.org/0000-0003-2480-724Xhttps://orcid.org/0000-0003-4214-0266https://orcid.org/0000-0003-2761-9447https://orcid.org/0000-0003-4829-8726https://orcid.org/0000-0001-6230-450Xhttps://orcid.org/0000-0002-2467-4697Revista Nacional - IndexadaS